Detalhe da pesquisa
1.
SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.
Bioorg Med Chem Lett
; 20(6): 1885-9, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20176482
2.
Mechanism and management of AKT inhibitor-induced hyperglycemia.
Clin Cancer Res
; 15(1): 217-25, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19118049
3.
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
J Pharmacol Exp Ther
; 328(1): 131-40, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18854490
4.
In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
J Pharmacol Exp Ther
; 324(3): 957-69, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18156464
5.
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity.
Mol Cancer Ther
; 6(7): 2012-21, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17620431
6.
Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.
J Med Chem
; 50(15): 3431-3, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17583334
7.
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
J Med Chem
; 49(25): 7270-3, 2006 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17149856
8.
Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
J Alzheimers Dis
; 7(2): 139-48; discussion 173-80, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15851852
9.
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
J Med Chem
; 47(26): 6447-50, 2004 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15588077
10.
Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.
J Med Chem
; 47(25): 6117-9, 2004 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15566281
11.
Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.
PLoS One
; 9(6): e100880, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24978597
12.
Evaluating scoring functions for docking and designing beta-secretase inhibitors.
Bioorg Med Chem Lett
; 17(3): 823-7, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17107793
13.
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg Med Chem Lett
; 17(14): 4057-61, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17482814
14.
A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
J Neurochem
; 96(1): 118-25, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16300640
15.
Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
Anal Biochem
; 342(1): 144-51, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15958191
16.
Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.
J Biol Chem
; 280(18): 17792-7, 2005 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15737955
17.
Rational design and synthesis of selective BACE-1 inhibitors.
Bioorg Med Chem Lett
; 14(3): 601-4, 2004 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14741251
18.
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
J Biol Chem
; 278(25): 22475-81, 2003 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12684521