[Sleep disorders and physical abuse: a nation-wide representative study in Hungary]. / Az alvászavarok prevalenciája a fizikailag bántalmazott nok körében: országos reprezentativ minta alapján.

OBJECTIVES: Violence against women has been declared a major public health concern. The relationship between physical abuse and physical and psychological symptoms is well-known, however data regarding the association between physical abuse and sleep disorders are limited. Our aim is to document the prevalence of reported abuse and investigate the association between physical abuse and insomnia among females. METHODS: Cross-sectional analyses were conducted on the female sample (N=6987) of the Hungarostudy 2002, a nationwide representative survey. The survey contained sociodemographic questions and a Hungarian version of Athen Insomnia Scale (AIS). RESULTS: We found higher (>10) AIS scores and all of the items of AIS reported higher prevalence among abused women's group than non-abused women. Physical abuse was found to be associated with sleep disturbances (OR=1,707), problems with staying asleep (OR=1,552) and decrease of daytime performance (OR=2,024) after controlling the potential risk factors. CONCLUSION: Women experiencing physical abuse have a significantly higher risk of sleep disorders. The relationship between physical abuse and insomnia deserves further investigation in order to determine the possible pathways of this association.

Clinical, Economic, and Humanistic Outcomes Associated with Obesity Among People with Bipolar I Disorder in the United States: Analysis of National Health and Wellness Survey Data.

Introduction: People living with bipolar I disorder (BD-I) have an increased risk for obesity compared with the general population that may be related to genetic, lifestyle, and treatment factors. Few studies have examined possible effects of obesity on those living with BD-I. This study examined relationships between obesity and clinical, humanistic, and economic outcomes among adults with BD-I. Methods: This retrospective, cross-sectional study analyzed survey responses from a nationally representative sample of US adults participating in the 2016 or 2020 National Health and Wellness Survey. Respondents (18-64 years) with a self-reported physician diagnosis of BD-I were included and categorized by body mass index: underweight/normal weight (<25 kg/m2), overweight (25 to <30 kg/m2), or obese (≥30 kg/m2). Adjusted analyses assessed comorbidities, health-related quality of life (HRQoL), work productivity, health care resource utilization (HCRU), and economic outcomes. Results: In total, responses from 1,853 participants were analyzed; most were female (65%) and white (62%). Respondents with obesity had the highest prevalence of medical comorbidities, including high blood pressure (52%), sleep apnea (37%), hypercholesterolemia (34%), and type 2 diabetes (12%). Obesity was generally associated with the lowest scores of physical health and HRQoL. Activity impairment scores were highest among respondents with obesity, as were numbers of hospitalizations and emergency department visits in the previous 6 months. Respondents with obesity incurred higher annual indirect and direct medical costs ($28,178 and $37,771, respectively) when compared with the underweight/normal weight ($23,823 and $32,227, respectively) and overweight ($24,312 and $35,231, respectively) groups. Conclusion: In this nationally representative sample, obesity was associated with several outcomes that may negatively affect people living with BD-I, including medical comorbidities, higher HCRU, HRQoL impairments, and greater indirect and direct medical costs. These findings highlight the importance of considering the presence of or risk for obesity and associated medical comorbidities when treating BD-I.

Work-related stress factors and menstrual pain: a nation-wide representative survey.

While imposing research has been conducted with respect to the biological determinants of painful menstruation, little is known about the psychosocial factors, including work-related stress that might influence menstrual pain. We conducted a study in which we aimed to determine besides the prevalence of dysmenorrhoea whether menstrual pain was associated with job control, co-worker social support, job security and dissatisfaction with the job. Data of 2772 working women aged 18-55 years, participants in the Hungarostudy 2002 nation-wide representative survey was analyzed. Binary logistic regression was used to determine the association between work stress factors and menstrual pain. Altogether 15.5% of women reported to experience menstrual pain that limits their daily activity. Low job control, low co-worker social support and low job security were found to be associated with a higher risk for menstrual pain even after controlling for the effect of age, educational attainment, parity status, smoking, body-mass index and treatment for gynecological problems. Job dissatisfaction was also related to dysmenorrhoea, albeit not significantly. The relationship between work-related psychosocial factors and painful menstruation deserves further investigation in order to determine the possible pathways of this association.

A Retrospective, Longitudinal, Claims-Based Comparison of Concomitant Diagnoses Between Individuals with and Without Down Syndrome.

BACKGROUND: Individuals with Down syndrome (DS) experience various comorbidities in excess of the prevalence seen among the non-DS population. However, the extent of the excess burden of comorbidities specifically within commercially and publicly insured DS populations aged < 21 years is not currently known. OBJECTIVES: To (a) describe the most common diagnoses among individuals with DS who have either commercial or Medicaid insurance and (b) compare the prevalence of those diagnoses between DS cases and non-DS controls. METHODS: This was a longitudinal, retrospective study using health care claims of commercially insured and Medicaid-insured individuals in the Truven Health MarketScan Databases from 2008 to 2015. Individuals aged < 2, 2-5, 6-11, and 12-20 years with a DS diagnosis (cases; commercial: n = 15,948; Medicaid: n = 11,958) were matched to individuals without DS (controls; commercial: n = 47,844; Medicaid: n = 35,874) using a 1:3 ratio. The annual number of diagnoses was compared between cases and controls within age groups using t-tests, and the prevalence of the most common diagnoses was compared using chi-square tests. RESULTS: Cases in all age groups in both databases had more diagnoses annually than controls (mean =9-17 per year vs. 4-10 per year, P < 0.001), and the number of diagnoses decreased with age for cases and controls. Among the most common case diagnoses were upper respiratory infections (28.9%-59.1% vs. 19.5%-52.9%); suppurative otitis media (25.1%-56.8% vs. 8.7%-51.2%); nutrition/metabolic/developmental symptoms (37.9%-50.4% vs. 7.7%-10.6%); delays in development (22.8%-52.8% vs. 4.1%-10.9%); and general symptoms (35.1%-47.2% vs. 22.1%-37.2%), and the prevalence of each was greater among cases versus controls in all age groups in both databases (P < 0.001). The most common diagnoses among controls included some of the same as among cases, as well as acute pharyngitis (18.7%-31.8% vs. 19.2%-30.5%); allergic rhinitis (19.9%-24.3% vs. 15.3%-20.7%); viral/chlamydial infections (24.2%-26.6% vs. 17.7%-23.5%); and joint disorders (11.6% vs. 16.6%), and most were significantly more prevalent among cases (P < 0.05). CONCLUSIONS: Commercially insured and Medicaid-insured individuals aged < 21 years with DS experience a greater number and prevalence of concomitant diagnoses compared with non-DS individuals. Awareness of these common diagnoses could help facilitate the optimal care of these individuals by the pediatric health care community. DISCLOSURES: This study was sponsored and funded by Genentech. Truven Health Analytics, an IBM Company, receives payment from Genentech to conduct research, including the research for this study. Truven Health Analytics also receives payment from other pharmaceutical companies to conduct research. Kong and Evans are employed by Truven Health Analytics. Csoboth is employed by Genentech. Brixner reports fees paid to the University of Utah by Truven Health Analytics on her behalf for work related to this study. Hurley reports fees from Genentech for work on this study and for work outside of this study. At the time of this study, Visootsak was employed by F. Hoffman-LaRoche Pharmaceuticals, parent company of Genentech. All authors, including those affiliated with the study sponsor, were involved in the design of the study, interpretation of the data, writing of the manuscript, and the decision to submit the manuscript for publication. Study concept and design were contributed by Kong, Hurley, and Brixner, along with Evans. Kong and Evans collected the data, and data interpretation was performed by Csoboth, Visootsak, Brixner, and Hurley, with assistance from Kong. The manuscript was written by Evans, Kong, Hurley, and Brixner and revised by Kong, Hurley, Evans, and Brixner, with assistance from Csoboth and Visootsak.

Examining the reliability and validity of the Clinical Assessment Interview for Negative Symptoms within the Management of Schizophrenia in Clinical Practice (MOSAIC) multisite national study.

The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CAINS were examined within the Management of Schizophrenia in Clinical Practice (MOSAIC) schizophrenia registry. A total of 501 participants with a schizophrenia spectrum diagnosis who were receiving usual care were recruited across 15 national Patient Assessment Centers and evaluated with the CAINS, other negative symptom measures, and assessments of functioning, quality of life and cognition. Temporal stability of negative symptoms was assessed across a 3-month follow-up. Results replicated the two-factor structure of the CAINS reflecting Motivation and Pleasure and expression symptoms. The CAINS scales exhibited high internal consistency and temporal stability. Convergent validity was supported by significant correlations between the CAINS subscales with other negative symptom measures. Additionally, the CAINS was significantly correlated with functioning and quality of life. Discriminant validity was demonstrated by small to moderate associations between the CAINS and positive symptoms, depression, and cognition (and these associations were comparable to those found with other negative symptom scales). Findings suggest that the CAINS is a reliable and valid tool for measuring negative symptoms in schizophrenia across diverse clinical samples and settings.

The relationship of biological and psychological risk factors of cardiovascular disorders in a large-scale national representative community survey.

A large-scale national representative community survey of 11,122 persons aged more than 35 years included the investigation of the coincidence of depressive symptoms, vital exhaustion, cardiovascular disorders, stroke, and myocardial infarction. A total of 20.3% of the survey participants reported having experienced a cardiovascular disorder (CVD). Of the subjects reporting a CVD, 52.1% exhibited depressive symptoms (22.0% subthreshold depressive symptoms, 30.1% clinical depression), and 69.7% exhibited vital exhaustion. The authors investigated 3 cardiovascular subgroups: (1) subjects having experienced a myocardial infarction (MI), (2) subjects having experienced stroke, and (3) subjects with a CVD but no experience of either an MI or a stroke. The frequency and severity of depressive symptoms did not differ significantly in the 3 subgroups. CVD subjects with no MI or stroke had almost as high frequencies of depressive symptoms and vital exhaustion as patients who experienced stroke or MI. The strength of relationships between these psychological variables and CVDs do not differ significantly from the relationships between hypertension or diabetes and CVDs. Depressive symptoms and increased vital exhaustion have exceptionally high comorbidity with CVDs. The authors detected the same high comorbidity among patients with a milder CVD and without stroke or MI. The assessment and management of depressive symptoms and vital exhaustion should be routine procedure in clinical cardiology.

Self-rated health and health damaging behaviour among young women in Hungary in connection with family background.

OBJECTIVES: To describe the relationship of subjective health and harmful lifestyle with familial risk factors, such as low parental educational level, parental psychiatric disorder reported by their offspring, alcohol use, and divorce. METHODS: 3615 hungarian women aged 15-24 in 1998. The questionnaire addressed socio-economic factors, physical and mental health, and health damaging behaviours. RESULTS: Low self-rated health (OR: 2.32; Cl: 1.54-3.47; p < 0.001) or at least five health complaints (OR: 2.09; CI: 1.68-2.60; p < 0.001) were significantly more common among women with reported parental psychiatric disorder. Drug use (OR: 2.35; CI: 1.86-2.98; p < 0.001) and regular or excessive alcohol consumption (OR: 1.86; CI: 1.46-2.37) was in strongest association with parental high education. CONCLUSIONS: Family related social problems, especially reported parental psychiatric disorders, regular alcohol consumption, and educational level, are important factors to be taken into account when planning specific interventions for young women.

Living in fear of experiencing physical and sexual abuse is associated with severe depressive symptomatology among young women.

PURPOSE: To analyze the relationship among fear of being abused, direct experience of physical and sexual abuse, and severe depressive symptoms among young women. METHODS: A cross-sectional survey was conducted in schools and households among 3615 young Hungarian women, ages 15-24 years, of whom 2016 were students. A multistage stratified sampling method was applied. The shortened Beck Depression Inventory (BDI) and the modified Abuse Assessment Screen were used. Odds ratios (ORs) were calculated, and a general linear model was used to test effects of variables on the BDI score. RESULTS: Severe depressive symptoms were significantly more common among women who were abused physically (OR=3.474, 95% CI 2.170-5.562) or sexually (OR=6.436, 95% CI 3.085-13.429) in the past year or abused by a partner (OR=3.167, 95% CI 1.806-5.554) or important person (OR=2.989, 95% CI 1.922-4.648) during their lifetime. Severe depressive symptoms were also found among those young women who reported feeling fearful of someone in the family (OR=5.027, 95% CI 2.805-9.012) or in their environment (OR=3.779, 95% CI 2.120-6.738). In a linear regression analysis, fear of someone in the environment or family had the strongest effect on BDI scores after controlling for frequent anxiety. CONCLUSIONS: Not only the direct lifetime experience of abuse but also the presence of fear of abuse is associated with severe depressive symptomatology among young women. Fear of abuse is also an important factor to take into consideration in assessing young women with depressive symptoms.

[The prevalence of suicide ideas and their psychosocial backgrounds among physicians]. / Az öngyilkossági gondolatok elofordulása és pszichoszociális háttértényezoi az orvostársadalomban.

AIMS: A growing body of evidence in the literature suggests that the prevalence of psychiatric morbidity including suicide is high among physicians. Suicidal ideas are the most important predictors of suicides and suicide attempts. The prevalence of suicidal ideas is higher among physicians compared to the general population. Our goal was to search the factors of suicidal ideas among Hungarian physicians on basis of nationwide representative survey, helping to elaborate prevention programs. METHODS: Data were collected from 298 female and 109 male physicians using questionnaires. 1,754 white-collar workers from a representative survey (Hungarostudy 2002) served as controls. Statistical analysis examined background factors of suicidal thoughts. RESULTS: We found that the prevalence of suicidal ideas among both female (20,3%) and male physicians (12,1%) was significantly higher than that in the respective control groups (12,3% - 7,6%). Female physicians also exhibited significantly higher prevalence of suicidal ideas (p=0.0058 és OR=1,901). Suicidal ideas were associated with work-related stress. Correlation analyses confirmed a significant relationship between high prevalence of suicidal ideas and long working hours (>8 hours), severe anxiety and work-related stress, and role conflict. Further examination of the background factors of suicidal thoughts may help to elaborate more effective health-prevention and conflict-dealing methods.

The humanistic and economic burden of providing care for a patient with schizophrenia.

BACKGROUND: Schizophrenia is a debilitating disorder that often requires the affected individual to receive part- or full-time care from a caregiver. AIMS: The purpose of this study was to examine the humanistic and economic burden of caring for an individual with Schizophrenia with regard to the measures of quality of life (QoL), work productivity, healthcare resource use and estimated economic costs. METHODS: Data for this study came from the 2012 US National Health and Wellness Survey (NHWS; n = 71,149). Specifically, this analysis focused on those individuals in the survey who indicated that they were currently the primary caregiver for an individual with Schizophrenia (C-SCZ; n = 174). These individuals were matched via two separate 1:2 propensity score matches with both caregivers of other disorders (C-Other; n = 294) and non-caregivers (Non-C; n = 294) on significant covariates. Individuals were then compared across the outcomes of QoL, work productivity, healthcare resource use and estimated economic costs. RESULTS: C-SCZ respondents had worse outcomes on all outcomes measured than C-Other respondents and Non-C respondents even when controlling for significant differences between the groups on sociodemographic characteristics. However, due to the small sample sizes, these comparisons were only significant in most cases for the C-SCZ to Non-C comparisons. CONCLUSION: Results indicate that caregivers of those with Schizophrenia experience a heightened humanistic and economic burden, especially relative to the burden experienced by non-caregivers. The fact that Schizophrenia not only affects the individual but also those who care for that individual is underscored by these results.

The Management of Schizophrenia in Clinical Practice (MOSAIC) Registry: a focus on patients, caregivers, illness severity, functional status, disease burden and healthcare utilization.

BACKGROUND: The Management of Schizophrenia in Clinical Practice (MOSAIC), a disease-based registry of schizophrenia, was initiated in December 2012 to address important gaps in our understanding of the impact and burden of schizophrenia and to provide insight into the current status of schizophrenia care in the US. Recruitment began in December 2012 with ongoing assessment continuing through May 2014. METHODS: Participants were recruited from a network of 15 centralized Patient Assessment Centers supporting proximal care sites. Broad entry criteria included patients diagnosed with schizophrenia, schizophreniform or schizoaffective disorder, presenting within the normal course of care, in usual treatment settings, aged ≥18years and able to read and speak English. RESULTS: By May 2014, 550 participants (65.8% male, 59.8% White, 64.4% single, mean age 42.9years), were enrolled. The majority had a diagnosis of schizophrenia (62.0%). Mean illness duration at entry was 15.0years. Common comorbidities at entry were high lipid levels (26.9%), hypertension (23.1%) and type II diabetes (13%). Participants were categorized by baseline overall Clinical Global Impression-Schizophrenia Severity Score as minimally (9.1%), mildly (25.3%), moderately (39.9%), markedly (22.3%) and severely (3.4%) ill. Most commonly used second generation antipsychotics at entry were risperidone (17.8%), clozapine (16.5%), olanzapine (14.0%), aripiprazole (13.6%) and quetiapine (5.6%). CONCLUSIONS: No large-scale patient registry has been conducted in the US to longitudinally follow patients with schizophrenia and describe symptom attributes, support network, care access and disease burden. These data provide important epidemiological, clinical and outcome insights into the burden of schizophrenia in the US.

Comorbidity of pain problems and depressive symptoms in young women: results from a cross-sectional survey among women aged 15-24 in Hungary.

Frequent headaches and musculoskeletal pain problems were assessed as part of a cross-sectional health survey in a representative sample of 3615 young Hungarian women, aged 15-24 (mean age: 19.0 years). The representative sample was obtained by a multilevel stratified sampling procedure based on national statistical data, the refusal rate was 6%. Depressive symptomatology was assessed as well using the shortened form of the Beck Depression Inventory. The overall prevalence of frequent headaches was 43.8% in the sample, 25.8% of the investigated population reported chronic musculoskeletal pain problems. The co-prevalence rate of depression was significantly higher in the group of interviewees reporting pain problems, 11.2% in the group indicating frequent headaches (chi(2)=53.1, p<0.001), 10.3% in the group reporting musculoskeletal pain problems (chi(2)=12.4, p<0.001). In contrast, the prevalence of depressive symptomatology was 4.6% and 6.6% in the subgroups denying frequent headaches and musculoskeletal pain, respectively. The prevalence of chronic pain problems decreased with higher age, increased with the smaller size of residence and was lower in the non-student employment group, however, these differences across sociodemographic variables did not remain significant if tested by a multivariate logistic regression analysis. The high co-prevalence rates of depression in interviewees reporting chronic pain problem draws attention to the development of such secondary health problems and underscores the importance of early prevention. Epidemiological studies provide data for the better planning and management of prevention programs.

Psychosocial determinants of premature health deterioration in a changing society: the case of Hungary.

The drastic increase of morbidity and mortality rates in the transforming Central-Eastern European countries, characterizing the last decades, offers a unique opportunity to analyse the relationship of those social, psychological and biological processes that contribute to rapid health modifications. In 1988 and 1995, two national representative surveys of the Hungarian population aged 16 or older (N = 20,902 and 12,640 respectively) were conducted. The results show that depressive symptom severity mediates between relative socio-economic deprivation and higher self-rated morbidity rates. The worsening of traditional risk factors such as alcohol consumption and smoking, are also the consequences of social and psychological problems. A vicious circle might be hypothesized between social deprivation and depressive symptomatology, which substantially contributes to higher morbidity and mortality rates.

Physical and sexual abuse: risk factors for substance use among young Hungarian women.

The authors used a multistage stratified sampling method to conduct a cross-sectional survey of a nationally representative sample of 3,615 Hungarian women aged 15 to 24 years to acquire epidemiologic data on physical and sexual abuse and analyze the relationship between abuse and health-risk behaviors. Just over 30% of the young women reported having experienced some type of abuse in their lifetimes. All maladaptive coping strategies, especially sedative use, were more prevalent among those who had experienced physical abuse. The prevalence of smoking, drinking alcohol, and experimenting with drugs was closely related to both physical and sexual abuse. Having experienced abuse is an important factor in young women's development of risky health behaviors. Clinicians should screen for abuse in this age group to prevent behaviors that lead to long-term health problems.

[Attendance of screening by young Gypsy women]. / A fiatal roma nók szúróvizsgálatokon való megjelenése.

In the study, the authors surveyed young Gipsy women's attendance of screening, as compared to non-Gipsy women of similar age groups. The survey was based on a national representative sample consisting of 1599 persons selected from women belonging to the age group between 18 and 24 years: out of them 4.3%, that is, 69 persons identified themselves as Gipsies. Manifold difference was observed between the Gipsy and non-Gipsy respondents, with respect to their attendance of screening tests (dental, gynaecological, pulmonary screening, etc.): in all cases the Gipsy women had the more unfavourable indices and, the problem of pulmonary screening seems to be the most alarming one, since Gipsies are an ethnic group living under extremely bad social conditions, with an increased risk of being exposed to infections of tuberculosis.