Healing Diabetic Ulcers with MoO3-X Nanodots Possessing Intrinsic ROS-Scavenging and Bacteria-Killing Capacities.

Diabetic ulcers (DUs) appearing as chronic wounds are difficult to heal due to the oxidative stress in the wound microenvironment and their high susceptibility to bacterial infection. A routine treatment combining surgical debridement with anti-infection therapy is widely used for treating DUs in the clinic, but hardly offers a satisfying wound healing outcome. It is known that a long-term antibiotic treatment may also lead to the drug resistance of pathogens. To address these challenges, new strategies combining both reactive oxygen species (ROS) scavenging and bacterial sterilization have been proposed for fighting against DUs. Following this idea, oxygen deficient molybdenum-based nanodots (MoO3-X ) for healing the DUs are reported. The ROS scavenging ability of MoO3-X nanodots is investigated and the antibacterial property of the nanodots is also demonstrated. The systematic cell and animal experimental results indicate that the MoO3-X nanodots can effectively reduce inflammation, promote epithelial cell regeneration, accelerate angiogenesis, and facilitate DUs recovery. Most importantly, they present excellent capacity to diminish infection of methicillin-resistant Staphylococcus aureus, manifesting the potent application prospect of MoO3-X nanodots for diabetic wound therapy.

Coupled Colloidal Quantum Dot Molecules.

ConspectusElectronic coupling and hence hybridization of atoms serves as the basis for the rich properties for the endless library of naturally occurring molecules. Colloidal quantum dots (CQDs) manifesting quantum strong confinement possess atomic-like characteristics with s and p electronic levels, which popularized the notion of CQDs as artificial atoms. Continuing this analogy, when two atoms are close enough to form a molecule so that their orbitals start overlapping, the orbitals energies start to split into bonding and antibonding states made out of hybridized orbitals. The same concept is also applicable for two fused core-shell nanocrystals in close proximity. Their band edge states, which dictate the emitted photon energy, start to hybridize, changing their electronic and optical properties. Thus, an exciting direction of "artificial molecules" emerges, leading to a multitude of possibilities for creating a library of new hybrid nanostructures with novel optoelectronic properties with relevance toward diverse applications including quantum technologies.The controlled separation and the barrier height between two adjacent quantum dots are key variables for dictating the magnitude of the coupling energy of the confined wave functions. In the past, coupled double quantum dot architectures prepared by molecular beam epitaxy revealed a coupling energy of few millielectron volts, which limits the applications to mostly cryogenic operation. The realization of artificial quantum molecules with sufficient coupling energy detectable at room temperature calls for the use of colloidal semiconductor nanocrystal building blocks. Moreover, the tunable surface chemistry widely opens the predesigned attachment strategies as well as the solution processing ability of the prepared artificial molecules, making the colloidal nanocrystals as an ideal candidate for this purpose. Despite several approaches that demonstrated enabling of the coupled structures, a general and reproducible method applicable to a broad range of colloidal quantum materials is needed for systematic tailoring of the coupling strength based on a dictated barrierThis Account addresses the development of nanocrystal chemistry to create coupled colloidal quantum dot molecules and to study the controlled electronic coupling and their emergent properties. The simplest nanocrystal molecule, a homodimer formed from two core/shell nanocrystal monomers, in analogy to homonuclear diatomic molecules, serves as a model system. The shell material of the two CQDs is structurally fused, resulting in a continuous crystal. This lowers the potential energy barrier, enabling the hybridization of the electronic wave functions. The direct manifestation of the hybridization reflects on the band edge transition shifting toward lower energy and is clearly resolved at room temperature. The hybridization energy within the single homodimer molecule is strongly correlated with the extent of structural continuity, the delocalization of the exciton wave function, and the barrier thickness as calculated numerically. The hybridization impacts the emitted photon statistics manifesting faster radiative decay rate, photon bunching effect, and modified Auger recombination pathway compared to the monomer artificial atoms. Future perspectives for the nanocrystals chemistry paradigm are also highlighted.

Optical format interconversion nodes between OOK and QPSK enabled by a reconfigurable two-dimensional vector mover.

An optical format interconversion scheme between on-off keying (OOK) and quadrature phase shift keying (QPSK) is proposed and verified in this paper. The conversion system mainly consists of a coherent vector combiner and a reconfigurable two-dimensional (2D) vector mover. As a key element of the proposed conversion system, the 2D vector mover is implemented by a non-degenerate phase-sensitive amplifier (PSA). The operating principle and theoretical derivations of the PSA-based 2D vector mover are fully introduced. The reconfigurable transfer characteristics of the vector mover are analyzed under different parameter settings to exhibit the flexible 2D moving function. The signal constellations, eye diagrams, spectrum, error vector magnitudes, and bit error ratios are estimated and depicted to validate the proposed idea. With the input signal-to-noise ratios of 20 dB and 25 dB, error-free conversions are achieved between 50G Baud OOK and QPSK. The scheme proposed in this paper fills the lack of the one-to-one interconversion between OOK and QPSK, and has potential applications in optical interconnect nodes, across-dimensional optical transmissions, and flexible optical transceivers.

Neck Barrier Engineering in Quantum Dot Dimer Molecules via Intraparticle Ripening.

Coupled colloidal quantum dot (CQD) dimers represent a new class of artificial molecules composed of fused core/shell semiconductor nanocrystals. The electronic coupling and wave function hybridization are enabled by the formation of an epitaxial connection with a coherent lattice between the shells of the two neighboring quantum dots where the shell material and its dimensions dictate the quantum barrier characteristics for the charge carriers. Herein we introduce a colloidal approach to control the neck formation at the interface between the two CQDs in such artificial molecular constructs. This allows the tailoring of the neck barrier in prelinked homodimers formed via fusion of multifaceted wurtzite CdSe/CdS CQDs. The effects of reaction time, temperature, and excess ligands are studied. The neck filling process follows an intraparticle ripening mechanism at relatively mild reaction conditions while avoiding interparticle ripening. The degree of surface ligand passivation plays a key role in activating the surface atom diffusion to the neck region. The degree of neck filling strongly depends also on the initial relative orientation of the two CQDs, where homonymous plane attachment allows for facile neck growth, unlike the case of heteronymous plane attachment. Upon neck filling, the observed red-shift of the absorption and fluorescence measured both for ensemble and single dimers is assigned to enhanced hybridization of the confined wave function in CQD dimer molecules, as supported by quantum calculations. The fine-tuning of the particle interface introduced herein provides therefore a powerful tool to further control the extent of hybridization and coupling in CQD molecules.

2D-to-1D constellation reforming using phase-sensitive amplifier-based constellation squeezing and shifting.

In this paper, a phase-sensitive amplifier (PSA)-based two dimensional (2D)-to-one dimensional (1D) constellation reforming system is proposed and analyzed in detail. The proposed system theoretically realizes seven kinds of 10 GBaud quadrature amplitude modulation (QAM)-to-pulse amplitude modulation (PAM) conversions, including quadrature phase shift keying-to-PAM4 and 8QAM-to-PAM8 conversions. The constellation reforming system consists of a constellation squeezing PSA and a multi-level vector moving PSA. The operating principle and formula derivations of constellation squeezing and vector moving processes are fully explained, including the PSA transfer characteristics and PSA gain axis angle analytical solutions. When implementing QAM-to-PAM conversions, the constellations, spectra, eye diagrams, error vector magnitudes and bit error ratio (BER) performances of the QAM and PAM signals are measured. For 8QAM-to-PAM8 conversion, with the input OSNR of 25 dB and 30 dB, at the BER of 10-3, the converted PAM8 shows the receiver OSNR of 38.9 dB and 35.2 dB, respectively. The proposed and verified 2D-to-1D constellation reforming system builds an optical bridge connecting long-haul and short-reach networks, which can be employed in the format conversion, high-order format signal generation and shaping, and flexible information aggregation/de-aggregation.

Rapidly liver-clearable rare-earth core-shell nanoprobe for dual-modal breast cancer imaging in the second near-infrared window.

BACKGROUND: Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200-400 nm) and visible light (Vis, 400-650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000-1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue. RESULTS: Here, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core-shell nanoparticles (Nd-RENPs), NaGdF4:5%Nd@NaLuF4, with strong emission in the NIR-II window. What's more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer. CONCLUSIONS: The rationally designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision.

Semiconductor Bow-Tie Nanoantenna from Coupled Colloidal Quantum Dot Molecules.

Top-down fabricated nanoantenna architectures of both metallic and dielectric materials show powerful functionalities for Raman and fluorescence enhancement with relevance to single molecule sensing while inducing directionality of chromophore emission with implications for single photon sources. We synthesize the smallest bow-tie nanoantenna by selective tip-to-tip fusion of two tetrahedral colloidal quantum dots (CQDs) forming a dimer. While the tetrahedral monomers emit non-polarized light, the bow-tie architecture manifests nanoantenna functionality of enhanced emission polarization along the bow-tie axis, as predicted theoretically and revealed by single-particle spectroscopy. Theory also predicts the formation of an electric-field hotspot at the bow-tie epicenter. This is utilized for selective light-induced photocatalytic metal growth at that location, unlike growth on the free tips in dark conditions, thus demonstrating bow-tie dimer functionality as a photochemical reaction center.

Phase-sensitive amplifier-based optical conversion for direct detection of complex modulation format to bridge long-haul transmissions and short-reach interconnects.

An optical conversion node scheme for direct detection of complex modulation format is proposed to bridge long-haul transmissions and short-reach interconnects. A noisy 10G Baud quadrature phase shift keying signal is converted into a 10G Baud normal 4-level pulse amplitude modulation (PAM4) signal by the node. The conversion node is realized mainly relies on four-wave mixing-based phase-sensitive amplifiers. The power ratio and constellation shape of the converted PAM4 both can be flexibly designed based on network demands and five kinds of uniform or non-uniform PAM4s are generated to verify the shaping functionality. With the input optical signal-to-noise ratio range of (10 dB∼30 dB), the key indicators of the signals went through every part are measured, includes constellations, eye diagrams, error vector magnitudes, bit error rates, normalized impact factors of phase and amplitude. The proposed node scheme has great application potential in intermediate nodes for bridging long-haul transmissions and short-reach interconnects, hierarchical modulation and flexible constellations design for advanced format signals.

Electronic coupling in colloidal quantum dot molecules; the case of CdSe/CdS core/shell homodimers.

Coupled colloidal quantum dot molecules composed of two fused CdSe/CdS core/shell sphere monomers were recently presented. Upon fusion, the potential energy landscape changes into two quantum dots separated by a pretuned potential barrier with energetics dictated by the conduction and valence band offsets of the core/shell semiconductors and the width controlled by the shell thickness and the fusion reaction conditions. In close proximity of the two nanocrystals, orbital hybridization occurs, forming bonding and antibonding states in analogy to the hydrogen molecule. In this study, we examine theoretically the electronic and optical signatures of such a quantum dot dimer compared to its monomer core/shell building-blocks. We examine the effects of different core sizes, barrier widths, different band offsets, and neck sizes at the interface of the fused facets on the system wave-functions and energetics. Due to the higher effective mass of the hole and the large valence band offset, the hole still essentially resides in either of the cores, breaking the symmetry of the potential for the electron as well. We found that the dimer signature is well expressed in a red shift of the band gap both in absorption and emission, in slower radiative lifetimes and in an absorption cross section which is significantly enhanced relative to the monomers at energies above the shell absorption onset, while remains essentially at the same level near the band-edge. This study provides essential guidance to predesign of coupled quantum dot molecules with specific attributes which can be utilized for various new opto-electronic applications.

Solvent Tailored Strategy for Synthesis of Ultrasmall Ag2S Quantum Dots with Near-Infrared-II Luminescence.

Highly luminescent semiconductor with ultrasmall size is always desirable for biomedical applications. Here, we developed a novel solvent-directing strategy to prepare ultrasmall monodispersed Ag2S quantum dots (QDs) with strong luminescence in the second near infrared (NIR-II) range (1000∼1400 nm). The particle size and luminescence of these Ag2S QDs could be desirably tuned by adjusting the solvents of the system. With further surface modification, the hydrophilic Ag2S QDs could be successfully utilised for cancerous cells imaging, indicating great potentials in biomedical fields.

Fluorine Grafted Cu7S4-Au Heterodimers for Multimodal Imaging Guided Photothermal Therapy with High Penetration Depth.

We report the multifunctional nanocomposites (NCs) consisting of 19F-moieties grafted Cu7S4-Au nanoparticles (NPs) for negligible background 19F-magnetic resonance imaging (19F-MRI) and computed tomography (CT) imaging guided photothermal therapy. The localized surface plasmon resonance (LSPR) absorption can be reasonably tuned to the in vivo transparent window (800-900 nm) by coupling Au (<10 nm, LSPR ∼530 nm) with Cu7S4 (<15 nm, LSPR ∼1500 nm) into Cu7S4-Au heterodimers. The in vivo photothermal tests show that Cu7S4-Au show deeper light penetration with 808 nm irradiation, better photothermal efficacy, and less damage to normal tissues than Cu7S4 with 1500 nm irradiation. Moreover, compared to traditional 1H-MRI, the 19F-MRI based on these NCs demonstrates much better sensitivity due to the negligible background. This work offers a promising strategy for multimodal imaging guided photothermal therapy of deep tissue with good efficacy.

Flexible generation of 28 Gbps PAM4 60 GHz/80 GHz radio over fiber signal by injection locking of direct multilevel modulated laser to spacing-tunable two-tone light.

To meet the ever-increasing bandwidth demands in the future broadband wireless networks, the millimeter-wave (mm-wave) frequency region is being actively perused, owing to its broad bandwidth and high frequencies. In this paper, a photonic mm-wave system is proposed and experimentally demonstrated based on the injection locking of a direct multilevel modulated laser to a spacing-tunable two-tone light. Since the mm-wave frequency of the generated signal is locked to the frequency spacing of the injected two-tone light, it shows better frequency stabilization than the schemes based on two free-running lasers. Moreover, by simply tuning the tone spacing, the mm-wave frequency could be easily re-configured, offering flexibility in the mm-wave signal generation. Instead of using complex and expensive optical modulators, the multilevel modulation on the mm-wave data carrier is implemented through the direct multilevel modulation of a laser and the injection locking. A 28 Gbps four-level pulse amplitude modulation (PAM4) is realized by biasing a 10 G-class laser at a current far from the threshold, providing a cost-effective and simple mm-wave generation scheme. In the experiment, a photonic approach to generating 28 Gbps PAM4 60 GHz/80 GHz mm-wave signals is experimentally demonstrated. A power penalty of less than 0.2 dB is observed for the filtered-out PAM4 signals with respect to the original PAM4. Besides, an ultra-low phase noise of up to -98 dBc/Hz is obtained for the mm-wave carriers after the injection locking. The proposed scheme possesses the flexibility and frequency stability of the mm-wave frequency, and also has low cost and implementation complexity.

Plasmon-Enhanced Photoelectrical Hydrogen Evolution on Monolayer MoS2 Decorated Cu1.75 S-Au Nanocrystals.

Hydrogen production from water splitting through an efficient photoelectrochemical route requires photoinduced electron transfer from light harvesters to efficient electrocatalysts. Here, the plasmon-enhanced photoelectrical nanocatalysts (NCs) have been successfully developed by coating a monolayer MoS2 on the Cu1.75 S-Au hetero-nanoparticle for hydrogen evolution reaction (HER). The plasmonic NCs dramatically improve the HER, leading to 29.5-fold increase of current under 650 nm excitation (1.0 W cm-2 ). These NCs generate an exceptionally high current density of 200 mA cm-2 at overpotential of 182.8 mV with a Tafel slope of 39 mV per decade and excellent stability, which is better than or comparable to the Pt-free catalysts with carbon rod as counter electrode. The enhanced HER performance can be attributed to the significantly improved broad light absorption (400-3000 nm), more efficient charge separation and abundant active edge sites of monolayer MoS2 . The studies may provide a facile strategy for the fabrication of efficient plasmon-enhanced photoelectrical NCs for HER.

Optical modulation format conversion from one QPSK to one BPSK with information-integrity-employing phase-sensitive amplifier.

In this paper, a scheme for optical modulation format conversion from one 20 Gbps quadrature phase-shift keying (QPSK) signal to one 20 Gbps binary phase-shift keying (BPSK) signal with information integrity is proposed and verified by simulation. The theory of degenerate phase-sensitive amplifier (PSA) employed as a phase de-multiplexer is derived in detail and used to decompose the in- (I) and quadrature- (Q) phase components of QPSK. Then the I and Q components are parallel-to-series converted into one BPSK. The constellations show that the phase noise of the original signal is effectively restrained by the conversion system through use of the PSA. The error vector magnitude and bit-error rate (BER) of the QPSK, converted BPSK, and a back-to-back BPSK are measured and compared with each other. We find that the BER performance of the converted BPSK is better than QPSK and maintains the original information integrity with different input signal quality. Some potential issues are also discussed as to practical implementation of the scheme. This modulation-format-conversion scheme has potential applications in improving the signal BER performance and flexible transmitters and receivers in software-defined networks.

Near-Infrared Plasmonic-Enhanced Solar Energy Harvest for Highly Efficient Photocatalytic Reactions.

We report a highly efficient photocatalyst comprised of Cu7S4@Pd heteronanostructures with plasmonic absorption in the near-infrared (NIR)-range. Our results indicated that the strong NIR plasmonic absorption of Cu7S4@Pd facilitated hot carrier transfer from Cu7S4 to Pd, which subsequently promoted the catalytic reactions on Pd metallic surface. We confirmed such enhancement mechanism could effectively boost the sunlight utilization in a wide range of photocatalytic reactions, including the Suzuki coupling reaction, hydrogenation of nitrobenzene, and oxidation of benzyl alcohol. Even under irradiation at 1500 nm with low power density (0.45 W/cm(2)), these heteronanostructures demonstrated excellent catalytic activities. Under solar illumination with power density as low as 40 mW/cm(2), nearly 80-100% of conversion was achieved within 2 h for all three types of organic reactions. Furthermore, recycling experiments showed the Cu7S4@Pd were stable and could retain their structures and high activity after five cycles. The reported synthetic protocol can be easily extended to other Cu7S4@M (M = Pt, Ag, Au) catalysts, offering a new solution to design and fabricate highly effective photocatalysts with broad material choices for efficient conversion of solar energy to chemical energy in an environmentally friendly manner.

Ultrasmall Cu7 S4 @MoS2 Hetero-Nanoframes with Abundant Active Edge Sites for Ultrahigh-Performance Hydrogen Evolution.

Increasing the active edge sites of molybdenum disulfide (MoS2 ) is an efficient strategy to improve the overall activity of MoS2 for the hydrogen-evolution reaction (HER). Herein, we report a strategy to synthesize the ultrasmall donut-shaped Cu7 S4 @MoS2 hetero-nanoframes with abundant active MoS2 edge sites as alternatives to platinum (Pt) as efficient HER electrocatalysts. These nanoframes demonstrate an ultrahigh activity with 200 mA cm(-2) current density at only 206 mV overpotential using a carbon-rod counter electrode. The finding may provide guidelines for the design and synthesis of efficient and non-precious chalcogenide nanoframe catalysts.

Highly Efficient Photothermal Semiconductor Nanocomposites for Photothermal Imaging of Latent Fingerprints.

Optical imaging of latent fingerprints (LFPs) has been widely used in forensic science and for antiterrorist applications, but it suffers from interference from autofluorescence and the substrates background color. Cu7S4 nanoparticles (NPs), with excellent photothermal properties, were synthesized using a new strategy and then fabricated into amphiphilic nanocomposites (NCs) via polymerization of allyl mercaptan coated on Cu7S4 NPs to offer good affinities toward LFPs. Here, we develop a facile and versatile photothermal LFP imaging method based on the high photothermal conversion efficiency (52.92%, 808 nm) of Cu7S4 NCs, indicating its effectiveness for imaging LFPs left on different substrates (with various background colors), which will be extremely useful for crime scene investigations. Furthermore, by fabricating Cu7S4-CdSe@ZnS NCs, a fluorescent-photothermal dual-mode imaging strategy was used to detect trinitrotoluene (TNT) in LFPs while still maintaining a complete photothermal image of LFP.

Cu7 S4 Nanosuperlattices with Greatly Enhanced Photothermal Efficiency.

According to the simulation, the self-assembly of Cu7 S4 nanocrystals would enhance the photothermal conversion efficiency (PCE) because of the localized surface plasmon resonance effects, which is highly desirable for photothermal therapy (PTT). A new strategy to synthesize Cu7 S4 nanosuperlattices with greatly enhanced PCE up to 65.7% under irradiation of 808 nm near infrared light is reported here. By tuning the surface properties of Cu7 S4 nanocrystals during the synthesis via thermolysis of a new single precursor, dispersed nanoparticles (NPs), rod-like alignments, and nanosuperlattices are obtained, respectively. To explore their PTT applications, these hydrophobic nanostructures are transferred into water by coating with home-made amphiphilic polymer while maintaining their original structures. Under identical conditions, the PCE are 48.62% and 56.32% for dispersed NPs and rod-like alignments, respectively. As expected, when the nanoparticles are self-assembled into nanosuperlattices, the PCE is greatly enhanced up to 65.7%. This strong PCE, along with their excellent photothermal stability and good biocompatibility, renders these nanosuperlattices good candidates as PTT agents. In vitro photothermal ablation performances have undoubtedly proved the excellent PCE of our Cu7 S4 nanosuperlattices. This research offers a versatile and effective solution to get PTT agents with high photothermal efficiency.

Ultrasound technology assisted colloidal nanocrystal synthesis and biomedical applications.

Non-invasive and high spatiotemporal resolution mythologies for the diagnosis and treatment of disease in clinical medicine promote the development of modern medicine. Ultrasound (US) technology provides a non-invasive, real-time, and cost-effective clinical imaging modality, which plays a significant role in chemical synthesis and clinical translation, especially in in vivo imaging and cancer therapy. On the one hand, the US treatment is usually accompanied by cavitation, leading to high temperature and pressure, so-called "hot spot", playing a significant role in sonochemical-based colloidal synthesis. Compared with the classical nucleation synthetic method, the sonochemical synthesis strategy presents high efficiency for the fabrication of colloidal nanocrystals due to its fast nucleation and growth procedure. On the other hand, the US is attractive for in vivo and medical treatment, with applications increasing with the development of novel contrast agents, such as the micro and nano bubbles, which are widely used in neuromodulation, with which the US can breach the blood-brain barrier temporarily and safely, opening a new door to neuromodulation and therapy. In terms of cancer treatment, sonodynamic therapy and US-assisted synergetic therapy show great effects against cancer and sonodynamic immunotherapy present unparalleled potentiality compared with other synergetic therapies. Further development of ultrasound technology can revolutionize both chemical synthesis and clinical translation by improving efficiency, precision, and accessibility while reducing environmental impact and enhancing patient care. In this paper, we review the US-assisted sonochemical synthesis and biological applications, to promote the next generation US technology-assisted applications.

Complete Mapping of Interacting Charging States in Single Coupled Colloidal Quantum Dot Molecules.

Colloidal quantum dots (CQDs), major building blocks in modern optoelectronic devices, have so far been synthesized with only one emission center where the exciton resides. Recent development of coupled colloidal quantum dots molecules (CQDM), where two core-shell CQDs are fused to form two emission centers in close proximity, allows exploration of how charge carriers in one CQD affect the charge carriers in the other CQD. Cryogenic single particle spectroscopy reveals that while CQD monomers manifest a simple emission spectrum comprising a main emission peak with well-defined phonon sidebands, CQDMs exhibit a complex spectrum with multiple peaks that are not all spaced according to the known phonon frequencies. Based on complementary emission polarization and time-resolved analysis, this is assigned to fluorescence of the two coupled emission centers. Moreover, the complex peak structure shows correlated spectral diffusion indicative of the coupling between the two emission centers. Utilizing Schrödinger-Poisson self-consistent calculations, we directly map the spectral behavior, alternating between neutral and charged states of the CQDM. Spectral shifts related to electrostatic interaction between a charged emission center and the second emission center are thus fully mapped. Furthermore, effects of moving surface charges are identified, whereby the emission center proximal to the charge shows larger shifts. Instances where the two emission centers are negatively charged simultaneously are also identified. Such detailed mapping of charging states is enabled by the coupling within the CQDM and its anisotropic structure. This understanding of the coupling interactions is progress toward quantum technology and sensing applications based on CQDMs.