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1.
Am J Pathol ; 186(5): 1195-205, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26968341

RESUMO

Fatal Lyme carditis caused by the spirochete Borrelia burgdorferi rarely is identified. Here, we describe the pathologic, immunohistochemical, and molecular findings of five case patients. These sudden cardiac deaths associated with Lyme carditis occurred from late summer to fall, ages ranged from young adult to late 40s, and four patients were men. Autopsy tissue samples were evaluated by light microscopy, Warthin-Starry stain, immunohistochemistry, and PCR for B. burgdorferi, and immunohistochemistry for complement components C4d and C9, CD3, CD79a, and decorin. Post-mortem blood was tested by serology. Interstitial lymphocytic pancarditis in a relatively characteristic road map distribution was present in all cases. Cardiomyocyte necrosis was minimal, T cells outnumbered B cells, plasma cells were prominent, and mild fibrosis was present. Spirochetes in the cardiac interstitium associated with collagen fibers and co-localized with decorin. Rare spirochetes were seen in the leptomeninges of two cases by immunohistochemistry. Spirochetes were not seen in other organs examined, and joint tissue was not available for evaluation. Although rare, sudden cardiac death caused by Lyme disease might be an under-recognized entity and is characterized by pancarditis and marked tropism of spirochetes for cardiac tissues.


Assuntos
Borrelia burgdorferi/isolamento & purificação , Morte Súbita Cardíaca/patologia , Doença de Lyme/patologia , Miocardite/patologia , Adulto , Autopsia , Feminino , Coração/microbiologia , Humanos , Imunoglobulina G/metabolismo , Imunoglobulina M/metabolismo , Masculino , Reação em Cadeia da Polimerase em Tempo Real
2.
Am J Forensic Med Pathol ; 31(3): 278-80, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20606573

RESUMO

We present a case of sudden death of a 7-year-old boy who at autopsy was found to have an undiagnosed glioblastoma. The boy was asymptomatic until 2 hours before death complaining of a headache and was later found unresponsive in bed. A medicolegal autopsy was notable for a large hemorrhagic mass of the right frontal lobe, which on analysis was diagnostic of a glioblastoma. We feel that this is a unique case for 2 main reasons; high-grade gliomas of the cerebral cortex are rare in the pediatric population, and it is unusual for a large neoplasm to remain asymptomatic until 2 hours prior to death.


Assuntos
Neoplasias Encefálicas/patologia , Morte Súbita/etiologia , Glioblastoma/patologia , Encéfalo/patologia , Hemorragia Cerebral/patologia , Criança , Patologia Legal , Cefaleia/etiologia , Humanos , Masculino
3.
J Forensic Sci ; 65(5): 1416-1423, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32579247

RESUMO

Hacking trauma is prevalent in forensic cases involving genocide and dismemberment, but research into the identification of this type of trauma is lacking. The present study examines characteristics of hacking and blunt force skeletal trauma in order to determine if there is a point at which blunt force trauma becomes distinguishable from hacking trauma. Ten implements with a range of blade angles (i.e., the striking surface of the implement) were used in conjunction with a controlled-force hacking device to impact 100 limb bones of white-tailed deer (Odocoileus virginianus). Observations of the trauma included the occurrence and degree of fragmentation, the entrance widths of the impacts, and composite scores of six hacking characteristics, especially the distinctive V-shaped kerf. ANOVA tests and regression analyses were used to assess the relationships between these characteristics and the blade angles. A significant relationship (p-value = 0.011) was found between the composite hacking scores and the blade angles, indicating that blunt force and hacking trauma can be distinguished. The entrance widths of the impacts exhibited a significant relationship with the blade angles (p-value = 0.037). There was also a significant relationship between the visibility of a V-shaped kerf in the bones (p-value = 0.003), with visibility decreasing around the 60° blade angle. These data should assist in establishing guidelines to differentiate hacking and blunt force skeletal trauma in cases where the implement is on a spectrum between sharp and blunt.


Assuntos
Fêmur/lesões , Fêmur/patologia , Úmero/lesões , Úmero/patologia , Ferimentos não Penetrantes/patologia , Ferimentos Perfurantes/patologia , Animais , Cervos , Desenho de Equipamento , Patologia Legal/métodos , Humanos , Modelos Animais , Modelos Estatísticos , Armas
4.
Hum Pathol ; 38(4): 593-7, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17239934

RESUMO

Mortality has been reported to complicate gastric bypass, with common causes of death attributable to anastomotic leaks, sepsis, hemorrhage, and bowel obstruction. We evaluated autopsy reports from 10 patients having undergone gastric bypass. Medical records were reviewed to identify comorbidities. Data of interest included preoperative electrocardiogram (EKG) abnormalities, cause of death, body weight, anastamosis appearance, heart weight, extent of coronary artery disease, ventricular size, liver weight, and gall bladder status. A total of 7 men and 3 women were autopsied. Average age was 40 years (range, 30-49 years), and mean body mass index at autopsy was 60.3 kg/m(2) (range, 33.2-80.9 kg/m(2)). Evidence of anastomotic leaks was present in 7 cases, resulting in 4 deaths. Death was attributed to pulmonary embolism in one case. There were 5 cardiac-related deaths, all attributed to arrhythmias. Microscopic evidence of coronary artery disease was observed in 6. Cardiomegaly was seen in all patients, left ventricular hypertrophy in 8, right ventricular hypertrophy in 3, and hepatomegaly in all 10. Nine patients were status post cholecystectomy. Of the 8 preoperative EKG available, abnormalities were identified in 5. After gastric bypass, death was attributed to cardiac-related causes, pulmonary embolism, and operative complications. A significant proportion of cardiac-related deaths occured in the absence of atherosclerosis. Most patients had preoperative EKG abnormalities. As a high incidence of cardiomegaly was observed, operative stress associated with the procedure may increase the risk of arrhythmia in morbid obesity. Consequently, in morbidly obese patients, a detailed preoperative cardiovascular evaluation is warranted to reduce postoperative mortality.


Assuntos
Derivação Gástrica/efeitos adversos , Obesidade Mórbida/cirurgia , Adulto , Arritmias Cardíacas/mortalidade , Autopsia , Causas de Morte , Feminino , Derivação Gástrica/mortalidade , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Mórbida/complicações , Obesidade Mórbida/mortalidade , Complicações Pós-Operatórias/mortalidade , Embolia Pulmonar/mortalidade
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