RE-START: Exploring the effectiveness of anti-calcitonin gene-related peptide resumption after discontinuation in migraine.

BACKGROUND AND PURPOSE: According to the latest European guidelines, discontinuation of monoclonal antibodies against calcitonin gene-related peptide (anti-CGRP MAb) may be considered after 12-18 months of treatment. However, some patients may worsen after discontinuation. In this study, we assessed the response following treatment resumption. METHODS: This was a prospective study conducted in 14 Headache Units in Spain. We included patients with response to anti-CGRP MAb with clinical worsening after withdrawal and resumption of treatment. Numbers of monthly migraine days (MMD) and monthly headache days (MHD) were obtained at four time points: before starting anti-CGRP MAb (T-baseline); last month of first treatment period (T-suspension); month of restart due to worsening (T-worsening); and 3 months after resumption (T-reintroduction). The response rate to resumption was calculated. Possible differences among periods were analysed according to MMD and MHD. RESULTS: A total of 360 patients, 82% women, with a median (interquartile range [IQR]) age at migraine onset of 18 (12) years. The median (IQR) MHD at T-baseline was 20 (13) and MMD was 5 (6); at T-suspension, the median (IQR) MHD was 5 (6) and MMD was 4 (5); at T-worsening, the median (IQR) MHD was 16 (13) and MMD was 12 (6); and at T-reintroduction, the median (IQR) MHD was 8 (8) and MHD was 5 (5). In the second period of treatment, a 50% response rate was achieved by 57.4% of patients in MHD and 65.8% in MMD. Multivariate models showed significant differences in MHD between the third month after reintroduction and last month before suspension of first treatment period (p < 0.001). CONCLUSION: The results suggest that anti-CGRP MAb therapy is effective after reintroduction. However, 3 months after resumption, one third of the sample reached the same improvement as after the first treatment period.

Magnetic resonance imaging assessment in patients with axial spondyloarthritis: development of checklists for use in clinical practice.

The objective of our study was to standardize magnetic resonance imaging (MRI) assessment of spine and sacroiliac joints in patients with axial spondyloarthritis (axSpA) and/or inflammatory spinal pain, by creating checklists and templates based on the opinions of rheumatologists and radiologists. A scientific committee developed a series of questionnaires with multiple items regarding MRI in patients with axial inflammatory pain and/or axSpA. Then an expert panel of rheumatologists and radiologists rated all items in a 9-point Likert scale. Finally, the scientific committee and the expert panel met to create the definitive documents. Several definitive checklists and templates were generated for rheumatologist-requested MRI and for radiologist-requested MRI reports of sacroiliac joint and spinal examinations. A technical requirement protocol was also agreed on. Our results could be useful in increasing understanding between rheumatologists and radiologists regarding MRI in axSpA diagnosis and follow-up.

Stenodema longicuneata (Carvalho and Rosas, 1966) (Hemiptera, Heteroptera, Miridae) in Patagonia: redescription, new synonym and geographic distribution.

The genus Stenodema Laporte, 1832 is a group of grass-feeding plant bugs worldwide distributed, with five species recorded for the Subantarctic sub-region (sunsu Morrone 2015). Males of Stenodema longicuneata (Carvalho and Rosas, 1966) are redescribed and photographed. Stenodema laolaoensis (Carvalho, 1985) is proposed as a junior synonym of S. longicuneata. New geographic records are provided and distributional and biogeographic issues are discussed.

Taxonomic notes on some neglected doryctine wasps (Hymenoptera: Braconidae) from Argentina described by J. Brthes and E. Blanchard.

The type specimens of Austrodolops eremitae Blanchard, Doryctes ridiaschinae Brthes, and Hormiopius ptericoptophagus Blanchard were studied and reclassified according to the current classification of the subfamily Doryctinae. The monotypic genera Austrodolops Blanchard and Hormiopius Blanchard are treated as junior synonyms of Allorhogas Gahan (syn. nov.) and Heterospilus Haliday (syn. nov.) respectively. Examination of the gall associated species D. ridiaschinae shows that it belongs in the genus Allorhogas. All species are redescribed and illustrated and the following new combinations are proposed: Allorhogas eremitae (Blanchard) (comb. nov.), Allorhogas ridiaschinae (Brthes) (comb. nov.) and Heterospilus ptericoptophagus (Blanchard) (comb. nov.). Lectotypes are designated for all studied species and the genus Doryctes is excluded from the currently known Argentine fauna.

Procedures for transferring organizational knowledge during generational change: A systematic review.

The loss of organizational knowledge has emerged as a prevalent issue for 21st-century organizations. This systematic review aims to scrutinize knowledge transfer procedures applied to individuals in managerial and intermediate positions during generational change or knowledge management initiatives. Following the PRISMA statement [1], this review progressed through four stages, applying inclusion and exclusion criteria, and ultimately identifying 28 articles for the final analysis. Descriptive indicators and content-related metrics were employed in the study. Key findings include: (1) predominant investment in knowledge retention studies and procedure design is observed among large companies, primarily in the secondary sector; (2) digitalization emerges as a critical aspect of effective organizational knowledge transfer procedures and protocols; (3) intra-organizational communication styles are predominantly employed for knowledge transfer; (4) organizations prefer a collective approach to transferring both tacit and explicit knowledge. In summary, this research offers fresh insights into a pivotal area of business management, showcasing originality in its exploration of knowledge transfer within the realms of generational change and knowledge management.

Infectious arthritis and the temporomandibular joint. A review.

OBJECTIVE: Microorganisms can cause acute infectious arthritis, chronic infectious arthritis, or reactive inflammatory arthritis. The aim of this study is to perform a narrative review of the pathophysiology, etiology, and diagnostic features of infectious arthritis and TMJ infectious arthritis. METHODS: A search of the literature was performed using Medline, Scielo, Embase, and Google Scholar databases. The terms employed for the search were "Temporomandibular Joint Disorders" and "Infectious Arthritis"; or "Septic Arthritis"; or "Bacterial, Fungal, or Viral Arthritis." Over three hundred articles were screened for eligibility. RESULTS: The selected articles were utilized to perform a narrative review of the general aspects of infectious arthritis and infectious arthritis affecting the TMJ. CONCLUSION: Infectious arthritis is a rare, yet very morbid, form of arthritis. Understanding general aspects of joint infections and specific features of TMJ infectious arthritis is imperative for an adequate diagnosis.

The Usability of ICTs in People with Visual Disabilities: A Challenge in Spain.

The use of ICTs provides autonomy, equity, and social inclusion to people with visual disabilities. The National Organization of the Spanish Blind (ONCE) offers its 70,462 legally-blind people the necessary resources for the usability of ICTs. Still, most individuals with visual disabilities do not have a similar support system. This research aims to expose and make visible the importance and need for ICTs usage in this group. The qualitative approach has allowed the modeling of a contextualized inductive process through two heterogeneous discussion groups: eight individuals with legal blindness and six with moderate visual impairment, as well as three in-depth interviews with experts in typhlotechnology, accessibility, and low vision. The following has been verified: there is a lot of misinformation among people with visual disabilities outside the coverage of ONCE; accessibility is still not a priority for companies and institutions when creating and developing products and services with Design for All; the need for more professionals to advise and train users with blindness and low vision is clear. In Spain, there are almost a million visually-impaired people not affiliated with ONCE, for whom access to technical aids and digital literacy is a priority problem in which the Government should intervene.

Teachers' Well-Being, Emotions, and Motivation During Emergency Remote Teaching Due to COVID-19.

This study explores the effects of the shift to emergency remote teaching (ERT) on teachers' levels of well-being, emotions, and motivation. A total of 936 Spanish teachers participated in this nationwide survey from all educational levels, thus allowing comparison among levels, which is a novelty and strength of our study. Four aspects were explored: (1) instructional adaptation to ERT; (2) well-being changes and the main challenges in this regard; (3) changes in emotions; and (4) changes in motivation and the main factors. Importantly, we explored a number of teacher characteristics (e.g., gender, age) for the three last aspects. Our results show that teachers felt the impact of ERT on their well-being, emotions, and motivation. Additionally, female teachers, teachers with students of low socioeconomic status (SES), in public schools, and primary and secondary teachers were the most affected groups. This indicates that the impact of ERT differed and some populations of teachers are more at risk of suffering burnout because of ERT.

Business Leadership from a Gender Perspective and Its Impact on the Work Environment and Employee's Well-Being in Companies in the Basque Country.

If the workplace environment is good, the health and well-being of employees will be good too. This research aims to distinguish whether there are differences when it comes to being directed by a man or a woman and whether this affects employees. An ad hoc questionnaire was applied, collecting personal information and including the MLQ-6 S. It was sent by mail and answered by 549 employees of 16 companies in the Basque Country, Spain. A total of 277 (50.5%) men and 272 (49.5%) women participated, among whom there were 63 managers. The methodology shows a double perspective of how employees understand and perceive the differences between male and female business leaders and how managers see themselves exercising this leadership. No significant differences have been perceived. Both men and women believe they make their employees feel good about exercising leadership (M = 42.11%, W = 48.00%) quite often. Employed women consider it more challenging to become leaders and reconcile their work-life. Men do not think so. Communication is the tool that women managers know best how to handle and where men seem to fail more. Working on it could achieve more business success and better health in employees.

The austral-most record of the genus Haemagogus Williston (Diptera: Culicidae).

INTRODUCTION: The genus Haemagogus Williston is restricted to Central America and North and middle of South America and it includes numerous species of yellow fever virus vectors. METHODS: Adult female and larvae mosquitoes were collected using hand aspirators and dipper and pipette, respectively. RESULTS: The first record of a species of Haemagogus and particularly of Haemagogus spegazzinii was from La Pampa, Argentina. With this registry, the number of species found in La Pampa province rises to 18. CONCLUSIONS: New information on breeding sites for the species and implications of this new record suggest a possible extension of distribution in the near future.

Sulphur poisoning of palladium catalysts used for methane combustion: effect of the support.

Four different supported palladium catalysts (using alumina, silica, zirconia and titania as supports), prepared by incipient wetness impregnation, were tested as catalysts for methane oxidation in presence of sulphur dioxide. The catalyst supported on zirconia showed the best performance, whereas the silica-supported one showed the fastest deactivation. Temperature-programmed desorption experiments of the poisoned catalysts suggest that SO(2) adsorption capacity of the support plays a key role in the catalyst poisoning. In order to study the effect of promoters, expected to improve the thermal stability and thioresistance of the catalyst, commercial zirconia modified by yttrium and lantane was tested as supports. It was found that the presence of these promoters does not improve the performance of the zirconia-supported catalyst. A deactivation model -- considering two different active sites (fresh and poisoning), pseudo-first order dependence on methane concentration and poisoning rate depending on sulphur concentration and fraction of non-poisoned palladium -- was used for modelling the deactivation behaviour.

Patient preference in migraine therapy. A randomized, open-label, crossover clinical trial of acute treatment of migraine with oral almotriptan and rizatriptan.

OBJECTIVE: To assess patient preference for almotriptan 12.5 mg vs rizatriptan 10 mg for the acute treatment of migraine. METHODS: Randomized, multicenter, open-label, crossover trial in which triptan-naïve patients treated two moderate/severe migraine attacks, the first with one triptan and the second with the other: 183 patients took rizatriptan followed by almotriptan and 189 treated in the reverse order. Patient preference was assessed with a self-administered questionnaire. RESULTS: Of those recording a preference (209), 54.5% preferred almotriptan, but statistical significance was not achieved. The main reason for preference for one or the other triptan was efficacy: 43% of patients preferring almotriptan gave faster headache relief as the reason and 34% cited faster return to normal activities. The corresponding values for rizatriptan were 47% and 38%. A significantly greater proportion of those preferring almotriptan cited fewer adverse events (AEs) as the reason. Almotriptan and rizatriptan were of comparable efficacy and both treatments were well tolerated; 9% of patients experienced AEs probably or possibly related to study medication after almotriptan vs 14% after rizatriptan. Almotriptan was associated with a significantly lower incidence of triptan-associated AEs in triptan-naïve patients (8.5% vs 18% with rizatriptan). CONCLUSION: Physicians should use information from meta-analyses and preference studies like this one to aid in the selection of a triptan with a high likelihood of providing rapid, sustained relief from pain coupled with an absence of AEs. About 55% of patients recording a preference in this trial preferred almotriptan, perhaps because of its combination of good efficacy and lower incidence of triptan-associated AEs.

Oxidation of trichloroethene over metal oxide catalysts: kinetic studies and correlation with adsorption properties.

The performance of bulk chromium oxide is compared with that of a Mn commercial catalyst for the deep oxidation of trichloroethene (1000-2500ppmv, 55h(-1) space velocity) in air, in dry and wet (20000ppm of H(2)O) conditions, in terms of activity, selectivity and stability. Chromium oxide was found to be more active (on a catalyst weight basis), however its activity decreases continuously with time on stream. The presence of water increases its stability, the Mn catalyst showing the opposite behaviour. The effect of water on the Cr catalyst can be explained according to the Deacon equilibrium, as the presence of water tends to decrease the Cl(2) concentration, assumed to be responsible of the catalyst deactivation. Regarding to the selectivity, the Mn catalyst yields C(2)Cl(4), CCl(4) and CHCl(3) as organochlorinated by-products, whereas chromium oxide produces only trace amounts of CCl(4). Simple power-law kinetics expressions (first-order for Mn and zero-order for Cr) provide fairly good fits for the evolution of the conversion with the temperature. Furthermore, the kinetic behaviour of chromium oxide can be represented with a Langmuir-Hinshelwood model taking into account the chlorine inhibitory effect.

A review of genus Nysius Dallas in Argentina (Hemiptera: Heteroptera: Orsillidae).

The orsillid genus Nysius Dallas is a complex and large genus with more than 100 described species worldwide, and includes many species of agricultural importance, one such example is N. simulans (Stål) from Argentina. Three species of Nysius are found in this country: N. simulans (Stål), N. irroratus (Spinola) and N. puberulus Berg. The material available for the present study, consisting of over 610 specimens, was collected by sweep-net, G-Vac and light trap in the provinces of Chubut (42° to 46°S; 63.5° to 72° W), La Pampa (35º to 39º south; 63º to 68º West), Neuquén (36° to 41° S; 68° to 71°W) and Río Negro (37° to 42°S; 62° to 71°W), in the central region of Argentina, during the years 2010-2014. Although the species N. simulans is frequently recorded as a pest of soybean crop, there exist no detailed description but only a brief general diagnosis. In the present contribution, therefore, we provide a detailed redescription as well as an updated distribution of N. simulans and N. irroratus, and a key for species of genus Nysius present in Argentina.

Additional information for Leptoglossus impictus (Stål 1859) (Hemiptera: Heteroptera: Coreidae: Coreinae: Anisoscelini) from Patagonia, Argentina.

The Patagonian subregion belongs to the Andean region, and is comprised of two provinces: Central Patagonia and Subandean Patagonia. It extends from central Mendoza, widening through Neuquén, Río Negro, Chubut, and Santa Cruz, to northern Tierra del Fuego, and reaches Chile (Morrone 2006). The knowledge of terrestrial Heteroptera in this region is poor and is limited to a few contributions (e.g. Berg 1979, Breddin 1898, Pennington 1920, Faúndez & Carvajal 2011, Faundez 2015).

Evaluating the sensitivity, reproducibility and flexibility of a method to test hard shell capsules intended for use in dry powder inhalers.

Pharmaceutical tests for hard shell capsules are designed for orally administered capsules. The use of capsules in dry powder inhalers is widespread and increasing and therefore more appropriate tests are required to ensure quality and determine if these capsules are fit for purpose. This study aims to determine the flexibility, reproducibility and sensitivity of a quantitative method that is designed to evaluate the puncture characteristics of different capsule shell formulations under different climatic conditions. A puncture testing method was used to generate force displacement curves for five capsule formulations that were stored and tested at two different temperatures (5°C and 19°C). Force-displacement puncture profiles were reproducible for individual capsule shell formulations. The methodology was able to discriminate between capsules produced using different primary materials i.e. gelatin versus hypromellose, as well as more minor changes to capsule formulation i.e. different material grades and excipients. Reduced temperature increased the forces required for capsule puncture however further work is required to confirm its significance. Results indicate the method provides a reproducible and sensitive means of evaluating capsule puncture. Future studies should validate the methodology at different test sites, using different operators and with different capsule shell formulations.

Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture.

The internal lubricant content (ILC) of inhalation grade HPMC capsules is a key factor to ensure good powder release when the patient inhales a medicine from a dry powder inhaler (DPI). Powder release from capsules has been shown to be influenced by the ILC. The characteristics used to measure this are the emitted dose, fine particle fraction and mass median aerodynamic diameter. In addition the ILC level is critical for capsule shell manufacture because it is an essential part of the process that cannot work without it. An experiment has been applied to the manufacture of inhalation capsules with the required ILC. A full factorial model was used to identify the controlling factors and from this a linear model has been proposed to improve control of the process.

Oxidation of methane over palladium catalysts: effect of the support.

This work is focused on the deep catalytic oxidation of methane over supported palladium catalysts. The influences of the metal loading, oxidation state of palladium, nature of supports, presence of promoters in the supports (for zirconia-based supports), and thermal stability have been studied experimentally. Catalysts were prepared by incipient wetness of commercially available supports with aqueous solutions of palladium nitrate. For gamma-alumina support, it was observed that the optimal amount of palladium is between 0.5% and 2%, with higher amounts leading to a loss in specific activity. Concerning the oxidation state of the catalyst, it is concluded that for all the supports tested in the present work, a reduction of the catalyst is not needed, yielding the same conversion at steady state catalysts reduced and oxidised. The thermal stability of various supported catalysts were also studied, zirconia supports being the most active. These supports, specially Y-modified zirconia support, do not suffer appreciable deactivation below 500 degrees C.

Contribution to the knowledge of Patagonia, Argentina: redescription of the genus Xenogenus Berg 1883 (Hemiptera: Heteroptera: Rhopalidae) and description of immature stages of Xenogenus gracilis Reed, 1899.

This is a review of Xenogenus Berg 1883 a Neotropical genus with two species: X. gracilis Reed (1899) and X. picturatum Berg 1883. Males of X. picturatum, males and females of X. gracilis are redescribed and illustrated; instars II-V of X. gracilis are described and illustrated. The host plant and new record data are also given for the latter.