Detalhe da pesquisa
1.
In Vivo Photoadduction of Anesthetic Ligands in Mouse Brain Markedly Extends Sedation and Hypnosis.
J Neurosci
; 43(13): 2338-2348, 2023 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36849414
2.
Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4-S5 linker in activation and slow inactivation.
Proc Natl Acad Sci U S A
; 118(28)2021 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34260401
3.
An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules.
J Biol Chem
; 293(29): 11283-11295, 2018 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29844014
4.
A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.
J Biol Chem
; 291(39): 20473-86, 2016 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27462076
5.
Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.
Anesth Analg
; 123(5): 1253-1262, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27464974
6.
Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.
J Biol Chem
; 289(40): 27456-68, 2014 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25086038
7.
Photoaffinity labeling the propofol binding site in GLIC.
Biochemistry
; 53(1): 135-42, 2014 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24341978
8.
Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.
J Biol Chem
; 288(9): 6178-89, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23300078
9.
Synthesis and Characterization of a Diazirine-Based Photolabel of the Nonanesthetic Fropofol.
ACS Chem Neurosci
; 12(1): 176-183, 2021 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33355437
10.
Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy.
Cardiovasc Res
; 116(6): 1175-1185, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31424496
11.
Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand.
ACS Chem Neurosci
; 10(11): 4716-4728, 2019 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31638765
12.
Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry.
Methods Enzymol
; 602: 231-246, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29588031
13.
Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites.
J Gen Physiol
; 150(9): 1317-1331, 2018 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30018039
14.
Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation.
ACS Chem Biol
; 12(5): 1353-1362, 2017 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28333442
15.
Macroscopic and macromolecular specificity of alkylphenol anesthetics for neuronal substrates.
Sci Rep
; 5: 9695, 2015 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25853337
16.
Role for the propofol hydroxyl in anesthetic protein target molecular recognition.
ACS Chem Neurosci
; 6(6): 927-35, 2015 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25799399
17.
Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics.
J Med Chem
; 45(9): 1879-86, 2002 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11960499
18.
Mechanisms revealed through general anesthetic photolabeling.
Curr Anesthesiol Rep
; 4(1): 57-66, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24563623
19.
Fluorinated Carbenes.
Chem Rev
; 96(5): 1585-1632, 1996 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11848805
20.
Inhalational anesthetic photolabeling.
Methods Mol Biol
; 617: 437-43, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20336439