Detalhe da pesquisa
1.
Machine and deep learning approaches for cancer drug repurposing.
Semin Cancer Biol
; 68: 132-142, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904426
2.
Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
Gastroenterology
; 160(4): 1359-1372.e13, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33307028
3.
A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer.
Ecotoxicol Environ Saf
; 233: 113330, 2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35189517
4.
Predicting Chemical Carcinogens Using a Hybrid Neural Network Deep Learning Method.
Sensors (Basel)
; 22(21)2022 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36365881
5.
A New Hybrid Neural Network Deep Learning Method for Protein-Ligand Binding Affinity Prediction and De Novo Drug Design.
Int J Mol Sci
; 23(22)2022 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430386
6.
ES-Screen: A Novel Electrostatics-Driven Method for Drug Discovery Virtual Screening.
Int J Mol Sci
; 23(23)2022 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36499162
7.
Proglumide Reverses Nonalcoholic Steatohepatitis by Interaction with the Farnesoid X Receptor and Altering the Microbiome.
Int J Mol Sci
; 23(3)2022 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163821
8.
Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient-derived primary prostate cells.
Prostate
; 80(14): 1233-1243, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32761925
9.
DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing.
BMC Bioinformatics
; 17(1): 202, 2016 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27151405
10.
Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations.
J Biol Chem
; 290(8): 4966-4980, 2015 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25538240
11.
Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease.
Bioorg Med Chem
; 23(5): 1102-11, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25650313
12.
Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.
J Immunol
; 190(12): 6198-208, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23686481
13.
AutoEpiCollect, a Novel Machine Learning-Based GUI Software for Vaccine Design: Application to Pan-Cancer Vaccine Design Targeting PIK3CA Neoantigens.
Bioengineering (Basel)
; 11(4)2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38671743
14.
AutoPepVax, a Novel Machine-Learning-Based Program for Vaccine Design: Application to a Pan-Cancer Vaccine Targeting EGFR Missense Mutations.
Pharmaceuticals (Basel)
; 17(4)2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675381
15.
Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK).
J Biol Chem
; 287(21): 17682-17692, 2012 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22433870
16.
Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA.
J Biol Chem
; 287(17): 14192-200, 2012 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22378781
17.
Predicting Dose-Dependent Carcinogenicity of Chemical Mixtures Using a Novel Hybrid Neural Network Framework and Mathematical Approach.
Toxics
; 11(7)2023 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37505571
18.
A Peptide Vaccine Design Targeting KIT Mutations in Acute Myeloid Leukemia.
Pharmaceuticals (Basel)
; 16(7)2023 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37513844
19.
Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.
Bioorg Med Chem
; 20(17): 5269-76, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22863530
20.
Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts.
Bioorg Med Chem
; 20(6): 2180-8, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364743