Detalhe da pesquisa
1.
Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer.
Cell Mol Life Sci
; 81(1): 28, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38212428
2.
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
Proc Natl Acad Sci U S A
; 118(43)2021 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34635581
3.
Mechanism-Based Macrocyclic Inhibitors of Serine Proteases.
J Med Chem
; 67(6): 4833-4854, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38477709
4.
Novel approaches to glycomimetic design: development of small molecular weight lectin antagonists.
Expert Opin Drug Discov
; 16(5): 513-536, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33337918
5.
Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression.
J Med Chem
; 64(24): 18158-18174, 2021 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34902246
6.
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
bioRxiv
; 2021 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34131661
7.
Recent progress on inhibitors of the type II transmembrane serine proteases, hepsin, matriptase and matriptase-2.
Future Med Chem
; 11(7): 743-769, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30945556
8.
Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin.
Medchemcomm
; 10(9): 1646-1655, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31803403
9.
Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology.
J Med Chem
; 62(2): 480-490, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30571119
10.
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease.
Eur J Med Chem
; 143: 881-890, 2018 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29227928
11.
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Eur J Med Chem
; 150: 334-346, 2018 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29544147
12.
Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease.
Eur J Med Chem
; 127: 41-61, 2017 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28038326
13.
Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.
Eur J Med Chem
; 126: 502-516, 2017 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914364
14.
Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides.
Antiviral Res
; 125: 84-91, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26658373
15.
Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease.
J Med Chem
; 59(5): 1899-913, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26823007
16.
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies.
Eur J Med Chem
; 119: 300-18, 2016 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27235842
17.
Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies.
J Med Chem
; 58(7): 3144-55, 2015 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25761614