Detalhe da pesquisa
1.
Monitoring drug-target interactions through target engagement-mediated amplification on arrays and in situ.
Nucleic Acids Res
; 50(22): e129, 2022 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36189884
2.
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
J Am Chem Soc
; 144(7): 2905-2920, 2022 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35142215
3.
Sensitive Protein Detection Using Site-Specifically Oligonucleotide-Conjugated Nanobodies.
Anal Chem
; 94(28): 10054-10061, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35786874
4.
Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase.
Chembiochem
; 22(9): 1597-1608, 2021 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33400854
5.
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3.
Biochemistry
; 58(35): 3634-3645, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31389685
6.
Structural Changes of Mercaptohexanol Self-Assembled Monolayers on Gold and Their Influence on Impedimetric Aptamer Sensors.
Anal Chem
; 91(22): 14697-14704, 2019 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31650834
7.
Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously.
FASEB J
; 31(3): 1204-1214, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27993994
8.
Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 112(19): E2543-52, 2015 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25918415
9.
Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+ /calmodulin-dependent kinase II.
J Mol Recognit
; 30(8)2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28449373
10.
Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.
Virol J
; 14(1): 236, 2017 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29228983
11.
Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease.
Bioorg Med Chem
; 24(12): 2603-20, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27160057
12.
Structural basis of ligand recognition in 5-HT3 receptors.
EMBO Rep
; 14(1): 49-56, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23196367
13.
Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.
Bioorg Med Chem
; 22(23): 6595-6615, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456385
14.
Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors.
J Enzyme Inhib Med Chem
; 29(6): 868-76, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24517372
15.
Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors.
SLAS Discov
; 29(1): 40-51, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37714432
16.
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors.
Biochemistry
; 52(4): 613-26, 2013 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23290007
17.
Efficient screening of marine extracts for protease inhibitors by combining FRET based activity assays and surface plasmon resonance spectroscopy based binding assays.
Mar Drugs
; 11(11): 4279-93, 2013 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24177674
18.
The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase.
Biomolecules
; 13(9)2023 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37759761
19.
The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces.
Biomolecules
; 13(12)2023 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38136634
20.
Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function.
J Mol Recognit
; 25(10): 495-503, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22996592