Detalhe da pesquisa
1.
Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening.
Bioconjug Chem
; 28(4): 1016-1023, 2017 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28156095
2.
2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency.
Bioorg Med Chem Lett
; 25(1): 113-6, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25435145
3.
A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport.
J Biol Chem
; 286(35): 30823-30836, 2011 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21730057
4.
Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway.
Bioorg Med Chem Lett
; 22(1): 76-81, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22172704
5.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold.
Bioorg Med Chem Lett
; 22(24): 7388-92, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142615
6.
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
Mol Pharmacol
; 79(1): 42-50, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20926757
7.
Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner.
Appl Environ Microbiol
; 76(6): 1975-80, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20097805
8.
A model for the solution structure of the rod arrestin tetramer.
Structure
; 16(6): 924-34, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18547524
9.
Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies.
Proteins
; 74(3): 630-42, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18704946
10.
Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor.
J Med Chem
; 49(3): 850-63, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16451051
11.
A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.
Clin Cancer Res
; 20(8): 2126-35, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24573549
12.
An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines.
J Biomol Screen
; 19(5): 614-27, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24441647
13.
Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.
J Med Chem
; 56(2): 534-46, 2013 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23231439
14.
Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators.
J Mol Model
; 18(9): 4437-46, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22592386
15.
Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133.
ACS Chem Biol
; 6(8): 845-56, 2011 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21615117
16.
The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.
ACS Chem Neurosci
; 2(12): 730-742, 2011 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22368764
17.
Evaluation of the biosynthetic proposal for the synthesis of marineosins A and B.
Org Lett
; 12(5): 1048-51, 2010 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20141121
18.
Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.
ACS Chem Neurosci
; 1(4): 288-305, 2010 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20414370
19.
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.
ACS Chem Neurosci
; 1(2): 104-121, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-21961051
20.
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptorâ 5 (mGlu5): from an artificial neural network virtual screen to an in vivo tool compound.
ChemMedChem
; 7(3): 406-14, 2012 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22267125