Detalhe da pesquisa
1.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Proc Natl Acad Sci U S A
; 114(23): E4676-E4685, 2017 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533375
2.
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.
Brain
; 141(5): 1390-1403, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29538645
3.
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation.
Free Radic Biol Med
; 208: 478-493, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37714439
4.
Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays.
STAR Protoc
; 3(2): 101265, 2022 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35391936
5.
Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors.
Antioxidants (Basel)
; 11(2)2022 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35204145
6.
The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2.
iScience
; 25(1): 103703, 2022 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35036882
7.
Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode.
J Med Chem
; 65(10): 7380-7398, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35549469
8.
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity.
Redox Biol
; 51: 102291, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35313207
9.
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
iScience
; 25(2): 103827, 2022 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35198887
10.
The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis.
Cells
; 10(8)2021 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34440821
11.
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease.
Open Biol
; 10(6): 200105, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32574549
12.
Downregulation of Keap1 Confers Features of a Fasted Metabolic State.
iScience
; 23(10): 101638, 2020 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103077
13.
Author Correction: C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.
Sci Rep
; 14(1): 4774, 2024 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38413644
14.
Omaveloxolone (SkyclarysTM) for patients with Friedreich's ataxia.
Trends Pharmacol Sci
; 44(6): 394-395, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37142519
15.
Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1.
Mol Nutr Food Res
; 62(18): e1700908, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29710398
16.
C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.
Sci Rep
; 8(1): 8037, 2018 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795117
17.
Regulation of the mammalian heat shock factor 1.
FEBS J
; 284(11): 1606-1627, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28052564
18.
Transcription factors NRF2 and HSF1 have opposing functions in autophagy.
Sci Rep
; 7(1): 11023, 2017 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28887499
19.
Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.
Mol Cell Biol
; 36(18): 2403-17, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27354066
20.
Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection.
Trends Pharmacol Sci
; 36(1): 6-14, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25465722