Detalhe da pesquisa
1.
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.
Cell
; 155(3): 552-66, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24243015
2.
Discovery of a proneurogenic, neuroprotective chemical.
Cell
; 142(1): 39-51, 2010 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20603013
3.
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
Nature
; 567(7748): 341-346, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30842654
4.
Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines.
Bioorg Med Chem Lett
; 99: 129624, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38272190
5.
Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice.
J Sleep Res
; 32(4): e13839, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808670
6.
The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin α interactions.
Biochem J
; 477(17): 3253-3269, 2020 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32776146
7.
A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins.
J Am Chem Soc
; 142(13): 6128-6138, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32163279
8.
A convergent approach toward fidaxomicin: Syntheses of the fully glycosylated northern and southern fragments.
Tetrahedron
; 79(4)2020 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33191957
9.
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Proc Natl Acad Sci U S A
; 114(1): 89-94, 2017 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994139
10.
A biosynthetically inspired synthesis of (-)-berkelic acid and analogs.
Tetrahedron
; 74(9): 909-919, 2018 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29867257
11.
Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.
J Biol Chem
; 291(20): 10515-27, 2016 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26984404
12.
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Bioorg Med Chem
; 25(20): 5433-5440, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28807574
13.
Vacuolar ATPase in phagosome-lysosome fusion.
J Biol Chem
; 290(22): 14166-80, 2015 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25903133
14.
Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B.
J Am Chem Soc
; 138(22): 7130-42, 2016 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27232659
15.
Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs.
Bioorg Med Chem Lett
; 25(20): 4393-8, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26372654
16.
Inhibition by cellular vacuolar ATPase impairs human papillomavirus uncoating and infection.
Antimicrob Agents Chemother
; 58(5): 2905-11, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24614368
17.
Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol
; 31(1): 139-149.e14, 2024 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37967558
18.
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers.
ACS Chem Biol
; 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38829020
19.
Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells.
J Med Chem
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38804887
20.
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.
J Biol Chem
; 287(42): 35324-35332, 2012 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22910914