Detalhe da pesquisa
1.
Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.
J Am Chem Soc
; 142(9): 4445-4455, 2020 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32064871
2.
Aspergillomarasmine A overcomes metallo-ß-lactamase antibiotic resistance.
Nature
; 510(7506): 503-6, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24965651
3.
Biased Complement Diversity Selection for Effective Exploration of Chemical Space in Hit-Finding Campaigns.
J Chem Inf Model
; 59(5): 1709-1714, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30943027
4.
Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space.
Bioorg Med Chem Lett
; 25(17): 3468-75, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26189081
5.
The comprehensive antibiotic resistance database.
Antimicrob Agents Chemother
; 57(7): 3348-57, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23650175
6.
Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms.
Antimicrob Agents Chemother
; 56(2): 757-64, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22083474
7.
Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole.
Mol Syst Biol
; 7: 499, 2011 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21694716
8.
Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
J Med Chem
; 64(9): 6329-6357, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33929852
9.
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
J Med Chem
; 63(14): 7773-7816, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32634310
10.
Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors.
Bioorg Med Chem
; 17(9): 3443-55, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19356937
11.
Diversity-oriented synthesis and preliminary biological screening of highly substituted five-membered lactones and lactams originating from an allyboration of aldehydes and imines.
J Comb Chem
; 11(1): 155-68, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19072614
12.
A robust screen for novel antibiotics: specific knockout of the initiator of bacterial DNA replication.
FEMS Microbiol Lett
; 281(2): 210-4, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18312360
13.
A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii.
PLoS One
; 13(3): e0193851, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29505586
14.
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery.
Cell Chem Biol
; 24(1): 98-109, 2017 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28017602
15.
Identification and characterization of new inhibitors of fungal homoserine kinase.
Chembiochem
; 12(8): 1179-82, 2011 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21538764
16.
Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5.
Mol Biosyst
; 2(10): 484-91, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17216029
17.
Antibiotic resistance by enzyme inactivation: from mechanisms to solutions.
Chembiochem
; 11(10): 1325-34, 2010 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20564281
18.
A forward chemical screen identifies antibiotic adjuvants in Escherichia coli.
ACS Chem Biol
; 7(9): 1547-55, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22698393
19.
ß-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents.
J Antibiot (Tokyo)
; 64(7): 483-7, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21522158
20.
Kinetic characterization of lipid II-Ala:alanyl-tRNA ligase (MurN) from Streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates.
J Biol Chem
; 283(50): 34571-9, 2008 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842590