Detalhe da pesquisa
1.
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.
J Infect Dis
; 219(9): 1464-1473, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30423128
2.
Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555627
3.
Apicoplast targeting of a Toxoplasma gondii transmembrane protein requires a cytosolic tyrosine-based motif.
Traffic
; 13(5): 694-704, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22288938
4.
A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway.
J Biol Chem
; 288(45): 32539-32552, 2013 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24072705
5.
An essential Trypanosoma brucei protein kinase: a functional analysis of regulation and the identification of inhibitors.
Front Parasitol
; 22023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38099268
6.
Evolving insights into protein trafficking to the multiple compartments of the apicomplexan plastid.
J Eukaryot Microbiol
; 56(3): 214-20, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19527348
7.
A thioredoxin family protein of the apicoplast periphery identifies abundant candidate transport vesicles in Toxoplasma gondii.
Eukaryot Cell
; 7(9): 1518-29, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18586952
8.
Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.
Int J Parasitol
; 46(13-14): 871-880, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27729271
9.
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
J Med Chem
; 59(13): 6531-46, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27309760
10.
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.
ACS Med Chem Lett
; 6(12): 1184-1189, 2015 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26693272
11.
Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption.
PLoS One
; 9(11): e112096, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25369183
12.
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
J Med Chem
; 55(5): 2416-26, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22320388
13.
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Nat Struct Mol Biol
; 17(5): 602-7, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20436472
14.
Sequential processing of the Toxoplasma apicoplast membrane protein FtsH1 in topologically distinct domains during intracellular trafficking.
Mol Biochem Parasitol
; 166(2): 126-33, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19450729
15.
A membrane protease is targeted to the relict plastid of toxoplasma via an internal signal sequence.
Traffic
; 8(11): 1543-53, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17822404