Detalhe da pesquisa
1.
Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats.
Xenobiotica
; 52(3): 219-228, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35379057
2.
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Xenobiotica
; 51(7): 796-810, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33938357
3.
Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole.
Xenobiotica
; 48(10): 1021-1027, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28845725
4.
Solid-State Characterization of Novel Propylene Glycol Ester Solvates Isolated from Lipid Formulations.
Mol Pharm
; 12(7): 2551-7, 2015 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26013841
5.
Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans.
Drug Metab Dispos
; 42(5): 918-31, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24608633
6.
Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats.
Drug Metab Dispos
; 42(5): 890-8, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24595682
7.
Degradation of a pharmaceutical in HPLC grade methanol containing trace level formaldehyde.
Pharm Dev Technol
; 18(4): 877-82, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-22686350
8.
An isolable acyclic hemiacetal of ansamitocin P-3.
Magn Reson Chem
; 50(3): 256-9, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22374862
9.
Absorption, distribution, metabolism, and excretion of [¹4C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening.
Drug Metab Dispos
; 39(6): 952-65, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21363998
10.
Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.
Drug Metab Dispos
; 39(10): 1840-9, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21742900
11.
Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.
Chem Res Toxicol
; 24(10): 1668-77, 2011 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21905702
12.
Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.
Chem Res Toxicol
; 23(5): 861-3, 2010 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20369854
13.
Bioactivation of flutamide metabolites by human liver microsomes.
Drug Metab Dispos
; 36(7): 1425-37, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18411402
14.
Chemoselective sp2-sp3 cross-couplings: iron-catalyzed alkyl transfer to dihaloaromatics.
Org Lett
; 15(14): 3698-701, 2013 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23829418
15.
Strategies for the analysis of highly reactive pinacolboronate esters.
J Chromatogr A
; 1229: 216-22, 2012 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22321949
16.
Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.
Drug Metab Dispos
; 35(7): 1081-8, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17403914
17.
In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.
Drug Metab Dispos
; 34(4): 709-17, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16434547
18.
Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine.
Drug Metab Dispos
; 33(12): 1920-4, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16204461