Pesquisa | BVS IEC

1.

Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model.

Yin, Mianmian; Smith, Jennifer A; Chou, Marissa; Chan, Jackie; Jittayasothorn, Yingyos; Gould, Douglas B; Caspi, Rachel R; Anderson, Mark S; DeFranco, Anthony L.

Proc Natl Acad Sci U S A ; 121(5): e2311487121, 2024 Jan 30.

Artigo em Inglês | MEDLINE | ID: mdl-38261611

2.

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-Î³-dependent elimination of Paneth cells.

Raetz, Megan; Hwang, Sun-Hee; Wilhelm, Cara L; Kirkland, Donna; Benson, Alicia; Sturge, Carolyn R; Mirpuri, Julie; Vaishnava, Shipra; Hou, Baidong; Defranco, Anthony L; Gilpin, Christopher J; Hooper, Lora V; Yarovinsky, Felix.

Nat Immunol ; 14(2): 136-42, 2013 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-23263554

3.

Innate B cells cleave to the marginal zone.

DeFranco, Anthony L.

Nat Immunol ; 18(3): 248-250, 2017 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-28198824

4.

Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.

Han, Daehee; Walsh, Matthew C; Cejas, Pedro J; Dang, Nicholas N; Kim, Youngmi F; Kim, Jihyun; Charrier-Hisamuddin, Laetitia; Chau, Lillian; Zhang, Qin; Bittinger, Kyle; Bushman, Frederic D; Turka, Laurence A; Shen, Hao; Reizis, Boris; Defranco, Anthony L; Wu, Gary D; Choi, Yongwon.

Immunity ; 38(6): 1211-22, 2013 Jun 27.

Artigo em Inglês | MEDLINE | ID: mdl-23791643

5.

B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.

Kirkland, Donna; Benson, Alicia; Mirpuri, Julie; Pifer, Reed; Hou, Baidong; DeFranco, Anthony L; Yarovinsky, Felix.

Immunity ; 36(2): 228-38, 2012 Feb 24.

Artigo em Inglês | MEDLINE | ID: mdl-22306056

6.

Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response.

Hou, Baidong; Saudan, Philippe; Ott, Gary; Wheeler, Matthew L; Ji, Ming; Kuzmich, Lili; Lee, Linda M; Coffman, Robert L; Bachmann, Martin F; DeFranco, Anthony L.

Immunity ; 34(3): 375-84, 2011 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-21353603

7.

B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle.

Tian, Meijie; Hua, Zhaolin; Hong, Sheng; Zhang, Zhimin; Liu, Can; Lin, Lin; Chen, Jiaorong; Zhang, Wei; Zhou, Xuyu; Zhang, Fuping; DeFranco, Anthony L; Hou, Baidong.

J Immunol ; 200(3): 937-948, 2018 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-29282308

8.

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

Wang, Huafeng; Li, Mengyi; Hung, Chiung Yu; Sinha, Meenal; Lee, Linda M; Wiesner, Darin L; LeBert, Vanessa; Lerksuthirat, Tassanee; Galles, Kevin; Suresh, Marulasiddappa; DeFranco, Anthony L; Lowell, Clifford A; Klein, Bruce S; Wüthrich, Marcel.

PLoS Pathog ; 12(8): e1005787, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-27542117

9.

"Dangerous crystals".

DeFranco, Anthony L.

Immunity ; 29(5): 670-1, 2008 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-19006690

10.

Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms.

Hou, Baidong; Reizis, Boris; DeFranco, Anthony L.

Immunity ; 29(2): 272-82, 2008 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-18656388

11.

Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses.

Rookhuizen, Derek C; DeFranco, Anthony L.

Proc Natl Acad Sci U S A ; 111(31): E3224-33, 2014 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-25053813

12.

Germinal centers and autoimmune disease in humans and mice.

DeFranco, Anthony L.

Immunol Cell Biol ; 94(10): 918-924, 2016 11.

Artigo em Inglês | MEDLINE | ID: mdl-27562062

13.

B cell-specific loss of Lyn kinase leads to autoimmunity.

Lamagna, Chrystelle; Hu, Yongmei; DeFranco, Anthony L; Lowell, Clifford A.

J Immunol ; 192(3): 919-28, 2014 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-24376269

14.

Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Hua, Zhaolin; Gross, Andrew J; Lamagna, Chrystelle; Ramos-Hernández, Natalia; Scapini, Patrizia; Ji, Ming; Shao, Haitao; Lowell, Clifford A; Hou, Baidong; DeFranco, Anthony L.

J Immunol ; 192(3): 875-85, 2014 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-24379120

15.

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.

Lamagna, Chrystelle; Scapini, Patrizia; van Ziffle, Jessica A; DeFranco, Anthony L; Lowell, Clifford A.

Proc Natl Acad Sci U S A ; 110(35): E3311-20, 2013 Aug 27.

Artigo em Inglês | MEDLINE | ID: mdl-23940344

16.

Contribution of Toll-like receptor signaling to germinal center antibody responses.

DeFranco, Anthony L; Rookhuizen, Derek C; Hou, Baidong.

Immunol Rev ; 247(1): 64-72, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22500832

17.

Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.

Wheeler, Matthew L; Defranco, Anthony L.

J Immunol ; 189(9): 4405-16, 2012 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-23024271

18.

Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.

Thompson, Afton L; Johnson, Brandi T; Sempowski, Gregory D; Gunn, Michael D; Hou, Baidong; DeFranco, Anthony L; Staats, Herman F.

J Immunol ; 188(6): 2834-46, 2012 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-22345651

19.

Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.

Hou, Baidong; Benson, Alicia; Kuzmich, Lili; DeFranco, Anthony L; Yarovinsky, Felix.

Proc Natl Acad Sci U S A ; 108(1): 278-83, 2011 Jan 04.

Artigo em Inglês | MEDLINE | ID: mdl-21173242

20.

B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.

Scapini, Patrizia; Lamagna, Chrystelle; Hu, Yongmei; Lee, Karim; Tang, Qizhi; DeFranco, Anthony L; Lowell, Clifford A.

Proc Natl Acad Sci U S A ; 108(41): E823-32, 2011 Oct 11.

Artigo em Inglês | MEDLINE | ID: mdl-21911371

BVS IEC

Instituto Evandro Chagas

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Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model.

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-Î³-dependent elimination of Paneth cells.

Innate B cells cleave to the marginal zone.

Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.

B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.

Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response.

B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle.

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

"Dangerous crystals".

Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms.

Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses.

Germinal centers and autoimmune disease in humans and mice.

B cell-specific loss of Lyn kinase leads to autoimmunity.

Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.

Contribution of Toll-like receptor signaling to germinal center antibody responses.

Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.

Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.

Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.

B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.