Phase retrieval by random binary amplitude modulation and ptychography principle.

An improved binary amplitude modulation-based phase retrieval method studied by means of simulations and experiments is presented in this paper. The idea of ptychography is introduced for the purpose of designing random binary amplitude masks. The masks have the features that part of the light transmission regions is overlapped with each other and the overlapping positions are randomly distributed. The requirement for the consistency of light field in overlapping regions forms a strong constraint which is similar to the overlap constraint in ptychography. The constraint makes the iterative algorithm have high convergence accuracy in comparison to that of the original binary amplitude modulation method. Influences of amounts and overlap ratio of the modulation mask on reconstruction accuracy and speed of imaging process are analyzed. The comparison between our method and the original binary amplitude modulation method is performed in order to verify the feasibility of the proposed method.

Dual-task convolutional neural network based on the combination of the U-Net and a diffraction propagation model for phase hologram design with suppressed speckle noise.

In this paper, a dual-task convolutional neural network based on the combination of the U-Net and a diffraction propagation model is proposed for the design of phase holograms to suppress speckle noise of the reconstructed images. By introducing a Fresnel transmission layer, based on angular spectrum diffraction theory, as the diffraction propagation model and incorporating it into U-Net as the output layer, the proposed neural network model can describe the actual physical process of holographic imaging, and the distributions of both the light amplitude and phase can be generated. Afterwards, by respectively using the Pearson correlation coefficient (PCC) as the loss function to modulate the distribution of the amplitude, and a proposed target-weighted standard deviation (TWSD) as the loss function to limit the randomness and arbitrariness of the reconstructed phase distribution, the dual tasks of the amplitude reconstruction and phase smoothing are jointly solved, and thus the phase hologram that can produce high quality image without speckle is obtained. Both simulations and optical experiments are carried out to confirm the feasibility and effectiveness of the proposed method. Furthermore, the depth of field (DOF) of the image using the proposed method is much larger than that of using the traditional Gerchberg-Saxton (GS) algorithm due to the smoothness of the reconstructed phase distribution, which is also verified in the experiments. This study provides a new phase hologram design approach and shows the potential of neural networks in the field of the holographic imaging and more.

Liquid-crystal-polymer binary diffractive optical elements with a sub-micrometer feature size realized by a contact polarization holography.

In this Letter, a contact polarization holographic photoalignment method is proposed. In the holographic recording, a phase mask is contacted with a photoalignment film, making light carrying wavefront information interfere with reference light in the near-field region to realize polarization holographic pattern recording with a sub-micrometer feature size. The relevant theoretical derivation is given, and holographic recording of a 0.4 µm feature-size phase mask is realized. The proposed method can conveniently realize liquid-crystal binary diffractive optical elements with a sub-micrometer feature size. Off-axis diffraction can also be realized by superimposing the grating information by changing the angle between the substrate and the interference light.

Research on Dynamic Evolution Model and Method of Communication Network Based on Real War Game.

Based on the data in real combat games, the combat System-of-Systems is usually composed of a large number of armed equipment platforms (or systems) and a reasonable communication network to connect mutually independent weapons and equipment platforms to achieve tasks such as information collection, sharing, and collaborative processing. However, the generation algorithm of the combat system in the existing research is too simple and not suitable for reality. To overcome this problem, this paper proposes a communication network generation algorithm by adopting the joint distribution strategy of power law distribution and Poisson distribution to model the communication network. The simulation method is used to study the operation under continuous attack on communication nodes. The comprehensive experimental results of the dynamic evolution of the combat network in the battle scene verify the rationality and effectiveness of the communication network construction.

Error tracking-control-reduction algorithm for designing diffractive optical element with high image reconstruction quality.

The use of the diffractive optical element (DOE) can often significantly reduce the size and enhance the performance of the optical system, but it is mostly prevented by low diffraction efficiency and serious speckle noise due to the quantization error. In this paper, an error tracking-control-reduction (ETCR) algorithm is proposed to suppress the quantization error, which adjusts the accumulative action, controls the current state and predicts the trend of the error. The simulation and experiment results verify that the ETCR algorithm has high diffraction efficiency which can be comparable with the Gerchberg-Saxton (GS) and Modified GS algorithms. Furthermore, the root-mean-square error (RMSE) of the proposed algorithm is significantly lower than that of the GS and MGS algorithms. Based on the proposed method, a 2-level DOE has been designed and fabricated to generate several grey images with only 0.05 RMSE.

Reconfigurable step-zoom metalens without optical and mechanical compensations.

A polarization-dependent metasurface that consists of nanobrick arrays with spatial varying dimensions in two orthogonal directions has shown independent phase control ability, which paves a new way to design a reconfigurable step-zoom lens with two different focal lengths depending on the polarization states of an incident beam. In this paper, we report a highly integrated step-zoom metalens with dual focal lengths based on double-sided metasurfaces sitting on a transparent substrate. By assigning the focal power and balancing the aberrations between the front and rear metasurfaces, a large field-of-view ( ± 20°) step-zoom metalens corrected for monochromatic aberrations was designed, and its high performance (nearly diffraction-limited image quality for both on-axis and off-axis imaging) was verified by full-wave numerical simulations. More interestingly, the image plane of the designed metalens keeps unchanged after the zoom switching, which will bring great convenience for practical applications. With the advantages such as ultra-compactness, flexibility, and simplicity, the proposed metalens indicates the potential in the fields that require highly integrated zoom imaging and beam focusing without optical and mechanical compensations.

Effective method for further magnifying the image in holographic projection under divergent light illumination.

Divergent light illumination can effectively increase the diffraction angle of holographic projection. However, the achieved maximum image size is limited to the geometric enlargement of the hologram size with the existing double-sampling Fresnel diffraction algorithm. In this paper, an effective method for further magnifying the image is proposed. The theoretical maximum size under divergent illumination is first analyzed. On this basis, a virtual intermediate plane is introduced between the source plane and the image plane. Then three-step diffraction calculation is performed to evaluate the Fresnel diffraction between the hologram plane and the image plane so that the sampling interval on the image plane is related to the position of the virtual plane and can be flexibly tuned. Consequently, the achieved image size can be further enlarged. The feasibility of the proposed method is demonstrated by simulations and experiments.

Depth perception based 3D holograms enabled with polarization-independent metasurfaces.

Metasurfaces consist of dielectric nanobrick arrays with different dimensions in the long and short axes can be used to generate different phase delays, predicting a new way to manipulate an incident beam in the two orthogonal directions separately. Here we demonstrate the concept of depth perception based three-dimensional (3D) holograms with polarization-independent metasurfaces. 4-step dielectric metasurfaces-based fan-out optical elements and holograms operating at 658 nm were designed and simulated. Two different holographic images with high fidelity were generated at the same plane in the far field for different polarization states. One can observe the 3D effect of target objects with polarized glasses. With the advantages of ultracompactness, flexibility and replicability, the polarization-independent metasurfaces open up depth perception based stereoscopic imaging in a holographic way.

Non-iterative phase-only Fourier hologram generation with high image quality.

We report a novel and non-iterative method for the generation of phase-only Fourier hologram for image projection. Briefly, target image is first added with a special quadratic phase and then padded with zeros. A complex Fourier hologram is generated via the simple fast Fourier transform. Subsequently, the error diffusion algorithm is applied to convert the complex hologram into a phase-only hologram. The numerical, as well as the optical reconstructed images with the proposed method are of higher visual quality and contain less speckle noise compared to the original random phase method, which add the random phase to the target image and then preserve the phase component of the complex hologram. The influences of quadratic phase and zero-padding on the image quality are also discussed in detail.

Vector optical field generation based on birefringent phase plate.

Vector optical field has recently gained interest in a variety of application fields due to its novel characteristics. Conventional approaches of generating vector optical fields have difficulties in forming highly continuous polarization and suffer from the issue of high energy utilization rates. In order to address these issues, in this study a single optical path was proposed to generate vector optical fields where the birefringent phase plate modulated a linear polarized light into a vector optical field, which was then demodulated to a non-uniform linear polarization distribution of the vector optical field by the polarization demodulation module. Both a theoretical model and numerical simulations of the vector optical field generator were developed, illustrating the relationship between the polarization distribution of the target vector optical field and the depth distribution of the birefringent phase plate. Furthermore, the birefringent phase plate with predefined surface distributions was fabricated by grayscale exposure and ion etching. The generated vector optical field was experimentally characterized, capable of producing continuous polarization with high light energy utilization ratio, consistent with simulations. This new approach may have the potential of being widely used in future studies of generating well-controlled vector optical fields.

High-accuracy method for holographic image projection with suppressed speckle noise.

Iterative Fourier transform algorithms are widely used for creating holograms in holographic image projection. However, the reconstructed image always suffers from the speckle noise severely due to the uncontrolled phase distribution of the image. In this paper, a new iterative method is proposed to eliminate the speckle noise. In the iteration, the amplitude and phase in the signal window in the output plane are constrained to the desired distribution and a special object-dependent quadratic phase distribution, respectively. Since the phase of the reconstructed image is assigned artificially, the speckle noise came from the destructive interference between the sampling points with random and erratic phase distribution can be eliminated. To verify the method, simulations and experiments are performed. And the result shows that high quality, low noise images can be achieved.

Ultracompact high-efficiency polarising beam splitter based on silicon nanobrick arrays.

Since the transmission of anisotropic nano-structures is sensitive to the polarisation of an incident beam, a novel polarising beam splitter (PBS) based on silicon nanobrick arrays is proposed. With careful design of such structures, an incident beam with polarisation direction aligned with the long axis of the nanobrick is almost totally reflected (~98.5%), whilst that along the short axis is nearly totally transmitted (~94.3%). More importantly, by simply changing the width of the nanobrick we can shift the peak response wavelength from 1460 nm to 1625 nm, covering S, C and L bands of the fiber telecommunications windows. The silicon nanobrick-based PBS can find applications in many fields which require ultracompactness, high efficiency, and compatibility with semiconductor industry technologies.

One exposure processing to fabricate spiral phase plate with continuous surface.

An economical method for fabricating spiral phase plate (SPP) with continuous surface is proposed in this paper. We use an interval to quantize a three dimensional surface of an SPP into two dimensional bars to form a binary mask. The exposure dose can be precisely distributed through this mask in the exposure process. We discuss the select criterion of the quantization interval and the fabricating processes of SPP in detail. In the results, we present the fabrication of four kinds of high quality SPPs with different topological charges. The morphology analysis and the corresponding optical measurements verify the reliability of our fabrication method.

All-silicon nanorod-based Dammann gratings.

Established diffractive optical elements (DOEs), such as Dammann gratings, whose phase profile is controlled by etching different depths into a transparent dielectric substrate, suffer from a contradiction between the complexity of fabrication procedures and the performance of such gratings. In this Letter, we combine the concept of geometric phase and phase modulation in depth, and prove by theoretical analysis and numerical simulation that nanorod arrays etched on a silicon substrate have a characteristic of strong polarization conversion between two circularly polarized states and can act as a highly efficient half-wave plate. More importantly, only by changing the orientation angles of each nanorod can the arrays control the phase of a circularly polarized light, cell by cell. With the above principle, we report the realization of nanorod-based Dammann gratings reaching diffraction efficiencies of 50%-52% in the C-band fiber telecommunications window (1530-1565 nm). In this design, uniform 4×4 spot arrays with an extending angle of 59°×59° can be obtained in the far field. Because of these advantages of the single-step fabrication procedure, accurate phase controlling, and strong polarization conversion, nanorod-based Dammann gratings could be utilized for various practical applications in a range of fields.

Hollow Nanospheres Array Fabrication via Nano-Conglutination Technology.

Hollow nanospheres array is a special nanostructure with great applications in photonics, electronics and biochemistry. The nanofabrication technique with high resolution is crucial to nanosciences and nano-technology. This paper presents a novel nonconventional nano-conglutination technology combining polystyrenes spheres (PSs) self-assembly, conglutination and a lift-off process to fabricate the hollow nanospheres array with nanoholes. A self-assembly monolayer of PSs was stuck off from the quartz wafer by the thiol-ene adhesive material, and then the PSs was removed via a lift-off process and the hollow nanospheres embedded into the thiol-ene substrate was obtained. Thiolene polymer is a UV-curable material via "click chemistry" reaction at ambient conditions without the oxygen inhibition, which has excellent chemical and physical properties to be attractive as the adhesive material in nano-conglutination technology. Using the technique, a hollow nanospheres array with the nanoholes at the diameter of 200 nm embedded into the rigid thiol-ene substrate was fabricated, which has great potential to serve as a reaction container, catalyst and surface enhanced Raman scattering substrate.

Multi-focus plasmonic lens design based on holography.

Multi-focus plasmonic lens with metallic nanoslits of variant widths have great potential applications in optical interconnection, integrated optics and nanophotonics. But the design method with simulated annealing algorithm or Yang-Gu algorithm requires complex calculation and multi focuses are limited to be set on the same output plane. In this paper, we propose a design method based on holography. The desired light field distribution and the incident plane wave can be treated as object wave and reference wave, respectively. So the calculation is relative simple and multi focuses can be located in different output plane. Numerical simulation of multi-focus lens design is performed through finite-difference time-domain (FDTD) method and the result confirms the feasibility of our method.

Surface enhanced Raman scattering substrate with metallic nanogap array fabricated by etching the assembled polystyrene spheres array.

A sensitive surface enhanced Raman scattering (SERS) substrate with metallic nanogap array (MNGA) is fabricated by etching of an assembled polystyrene (PS) spheres array, followed by the coating of a metal film. The substrate is reproducible in fabrication and sensitive due to the nanogap coupling resonance (NGCR) enhancement. The NGCR is analyzed with the finite difference time domain (FDTD) method, and the relationship between the gap parameter and the field enhancement is obtained. Experimental measurements of R6G on demonstrate that the enhancement factor (EF) of the MNGA SERS substrate is increased by more than two fold compared with the control sample.

Prognostic models for early and late tumor progression prediction in nasopharyngeal carcinoma: An analysis of 8292 endemic cases.

OBJECTIVES: The time for posttreatment tumor progression differs between nasopharyngeal carcinoma (NPC) patients. Herein, we established effective nomograms for predicting early tumor progression (ETP) and late tumor progression (LTP) in NPC patients. METHODS: We retrospectively enrolled 8292 NPC patients (training cohort: n = 6219; validation cohort: n = 2073). The ELP and LTP were defined as the time to tumor progression ≤24 and >24 months after treatment, respectively. RESULTS: The ETP and LTP accounted for 52.6 and 47.4% of the total patient cohort, respectively. Patients who developed ETP had markedly worse overall survival (OS) versus patients who suffered from LTP (5-year OS: 26.2% vs. 59.7%, p < 0.001). Further, we identified 10/6 predictive factors significantly associated with ETP/LTP via logistic regression analyses. These indicators were used separately to construct two predictive nomograms for ETP and LTP. In the training group, the ETP nomogram [Harrell Concordance Index (C-index) value: 0.711 vs. 0.618; p < 0.001] and LTP nomogram (C-index value: 0.701 vs. 0.612; p < 0.001) were significantly superior for risk stratification than the TNM staging. These results were supported in the validation group with a C-index value of 0.753 and 0.738 for the ETP and LTP nomograms, respectively. High-risk patients defined by ETP/LTP nomograms had shorter progression-free survival than low-risk patients (all p < 0.001). CONCLUSION: The established nomograms can help in ELP or LTP risk stratification for NPC patients. Our current results might also provide insights into individualized treatment decisions and designing surveillance strategies for NPC patients.

Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells.

Zinc finger protein 154 (ZNF154) is hypermethylated at the promoter in many epithelial-derived solid tumors. However, its methylation status and function in esophageal squamous carcinoma (ESCC) are poorly understood. We found that the ZNF154 promoter is hypermethylated in ESCC and portends poor prognosis. In addition, ZNF154 functions as a tumor suppressor gene (TSG) in ESCC, and is downregulated by promoter hypermethylation. We established a targeted demethylation strategy based on CRISPR/dCas9 technology and found that the hypermethylation of ZNF154 promoter repressed ZNF154 induction, which in turn promoted the proliferation and migration of ESCC cells in vitro and in vivo. Finally, high-throughput CUT&Tag analysis, GEPIA software and qPCR were used to revealed the role of ZNF154 as a transcription factor to upregulate the expression of ESCC-associated tumor suppressor genes. Taken together, hypermethylation of the ZNF154 promoter plays an important role in the development of ESCC, and epigenetic editing is a promising tool for inhibiting ESCC cells with aberrant DNA methylation.

Resolution and stability analysis of localized surface plasmon lithography on the geometrical parameters of soft mold.

We have recently shown that patterns with 30 nm line width and micrometer scale periodicity could be steadily fabricated by employing localized surface plasmons lithography based on a soft mold [Opt. Lett. 35, 13 (2009)]. In this paper, the dependence of the resolution (pattern periodicity), critical dimension, and electric field intensity on the geometrical parameters of the soft mold, such as ridge width, mold periodicity, ridge depth, and slope, have been systematically studied and analyzed. The relevant simulation results by finite-difference time-domain demonstrate that the critical dimension exhibits a perfect stabilization and the value of electric field intensity would be especially large, when the ridge depth is in the range from 100 to 270 nm and the slope angle is below 35°. Importantly, the optimal resolution and critical dimension can reach 100 and 17 nm, respectively, by reasonably designing the corresponding mold periodicity and ridge width, which indicates that the method is particularly suitable for obtaining patterns with high density and is extremely promising for bio-sensing and photonic crystals application.