Detalhe da pesquisa
1.
The von Willebrand factor-binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A.
Blood
; 141(10): 1147-1158, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36108308
2.
The von Willebrand factor A-1 domain binding aptamer BT200 elevates plasma levels of von Willebrand factor and factor VIII: a first-in-human trial.
Haematologica
; 107(9): 2121-2132, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34818873
3.
Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial.
Blood
; 133(9): 893-901, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559259
4.
Safety, tolerability, pharmacokinetics and pharmacodynamics of parenterally administered dutogliptin: A prospective dose-escalating trial.
Br J Clin Pharmacol
; 86(5): 979-990, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31912513
5.
Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study of the Penetration of a Monoclonal Antibody Combination (ASN100) Targeting Staphylococcus aureus Cytotoxins in the Lung Epithelial Lining Fluid of Healthy Volunteers.
Antimicrob Agents Chemother
; 63(8)2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31138568
6.
Selective glucocorticoid receptor modulation inhibits cytokine responses in a canine model of mild endotoxemia.
Pharmacol Res
; 125(Pt B): 215-223, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28923543
7.
Morphine decreases ticagrelor concentrations but not its antiplatelet effects: a randomized trial in healthy volunteers.
Eur J Clin Invest
; 46(1): 7-14, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26449338
8.
Potent irreversible P2Y12 inhibition does not reduce LPS-induced coagulation activation in a randomized, double-blind, placebo-controlled trial.
Clin Sci (Lond)
; 130(6): 433-40, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26554025
9.
Dissociation between systemic and pulmonary anti-inflammatory effects of dexamethasone in humans.
Br J Clin Pharmacol
; 81(5): 865-77, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26647918
10.
A randomized, double-blind study on the safety and immunogenicity of rTSST-1 variant vaccine: phase 2 results.
EClinicalMedicine
; 67: 102404, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38274114
11.
Reversal strategy in antagonizing the P2Y12 -inhibitor ticagrelor.
Eur J Clin Invest
; 43(12): 1258-61, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24112116
12.
Recovery, safety, and tolerability of a solvent/detergent-treated and prion-safeguarded transfusion plasma in a randomized, crossover, clinical trial in healthy volunteers.
Transfusion
; 53(9): 1906-17, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23320451
13.
Effects of prasugrel on platelet inhibition during systemic endotoxaemia: a randomized controlled trial.
Clin Sci (Lond)
; 123(10): 591-600, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22646240
14.
Micellar Curcumin: Pharmacokinetics and Effects on Inflammation Markers and PCSK-9 Concentrations in Healthy Subjects in a Double-Blind, Randomized, Active-Controlled, Crossover Trial.
Mol Nutr Food Res
; 66(22): e2200139, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36101515
15.
Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Detection Tests Using Oral, Anterior Nasal, and Nasopharyngeal Swabs: a Diagnostic Accuracy Study.
Microbiol Spectr
; 10(1): e0202921, 2022 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35107327
16.
The VWF binding aptamer rondoraptivon pegol increases platelet counts and VWF/FVIII in type 2B von Willebrand disease.
Blood Adv
; 6(18): 5467-5476, 2022 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35772170
17.
Platelet hyperfunction is decreased by additional aspirin loading in patients presenting with myocardial infarction on daily aspirin therapy.
Crit Care Med
; 38(6): 1423-9, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20400900
18.
Effects of aspirin and NO-aspirin (NCX 4016) on platelet function and coagulation in human endotoxemia.
Platelets
; 21(5): 320-8, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20608787
19.
Differential Osteoprotegerin Kinetics after Stimulation with Desmopressin and Lipopolysaccharides In Vivo.
Thromb Haemost
; 120(7): 1108-1115, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32483770
20.
The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin.
Sci Rep
; 10(1): 11180, 2020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32636459