Detalhe da pesquisa
1.
Acoustic Ejection Mass Spectrometry for High-Throughput Analysis.
Anal Chem
; 93(31): 10850-10861, 2021 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320311
2.
Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19.
Org Process Res Dev
; 2023 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37552749
3.
Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
J Biol Chem
; 286(48): 41510-41519, 2011 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21953464
4.
Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes.
Bioorg Med Chem Lett
; 22(17): 5721-6, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858141
5.
Concerted vs stepwise mechanisms in dehydro-Diels-Alder reactions.
J Org Chem
; 76(22): 9320-8, 2011 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21977993
6.
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Bioorg Med Chem Lett
; 20(7): 2383-8, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20219367
7.
Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry.
ACS Med Chem Lett
; 11(6): 1101-1110, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32550988
8.
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Bioorg Med Chem Lett
; 19(9): 2400-3, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19346127
9.
3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.
J Med Chem
; 46(3): 353-5, 2003 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12540233
10.
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
J Med Chem
; 55(7): 3414-24, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22420884
11.
Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.
J Med Chem
; 55(2): 935-42, 2012 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148323
12.
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
J Med Chem
; 54(22): 7772-83, 2011 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21995460
13.
The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor.
Bioorg Med Chem Lett
; 16(9): 2525-7, 2006 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16464581