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1.
J Perinat Med ; 51(6): 815-822, 2023 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-37068268

RESUMO

OBJECTIVES: To assess the feasibility of identifying fetal brain structures and anatomic landmarks included in the anterior complex (AC) and posterior complex (PC), as well as the proximal hemisphere (PH). METHODS: This was a prospective observational multicenter study of healthy pregnant women evaluated by ultrasound screening at 24 to 36 + 6 weeks' gestation. Six physicians performed transabdominal ultrasound, to obtain the planes required to visualize the AC, PC, and PH. Blind analysis by an expert and non-expert operator in fetal neurosonography was used to assess the structures included in each plane view. RESULTS: In the population studied (n=366), structure detection rates for AC were over 95 %, with an agreement of 96 % when comparing expert and non-expert examiners. Visualization of the corpus callosum crossing the midline was detected in over 97 and 96 % of cases for the AC and PC, respectively, with an agreement of over 96 %. The PH plane, particularly through the posterior access via the mastoid fontanelle, enabled visualization of the proximal anatomical structures in almost 95 % of cases. Detection of the corpus callosum through the AC and PC, both proximal/distal germinal matrix (AC) and proximal Sylvian fissure through the anterior access (PH) in the 24-25 + 6, 26-31 + 6 and 32-36 + 6 weeks' gestation groups were successful in over 96 % of cases with high level of agreement. CONCLUSIONS: Inclusion of AC, PC, and PH later in pregnancy proves feasible with a high level of agreement between both expert and non-expert operators.


Assuntos
Encéfalo , Ultrassonografia Pré-Natal , Gravidez , Feminino , Humanos , Estudos de Viabilidade , Ultrassonografia , Idade Gestacional , Encéfalo/diagnóstico por imagem
2.
Prenat Diagn ; 40(5): 596-604, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31994747

RESUMO

OBJECTIVE: To assess the feasibility of identifying structures included in anterior complex (AC) and posterior complex (PC), as well as a series of anatomic landmarks that could help to demonstrate the integrity of the cerebral proximal hemisphere (PH). METHODS: This was a prospective observational multicenter study of healthy pregnant women attending routine ultrasound screening at 20 + 0 to 33 + 6 weeks' gestation. Six physicians performed transabdominal (TA) ultrasound, in order to obtain the planes required to visualize the AC, PC, and PH. Blind analysis by a nonexpert and two experts in fetal neurosonography was used to assess the structures included in each plane view. RESULTS: In the population studied (n = 747), detection of the structure rates for AC, PC, and proximal hemisphere was of 94%, 93%, and 96%, respectively, with an agreement of 97%, 94%, and 98% when comparing an expert and a nonexpert in fetal brain examiner. Detection of structures in the proximal hemisphere was significantly higher when observed through the proximal hemisphere plane rather than the transventricular plane. CONCLUSION: Our results suggest that inclusion of AC and PC complexes visualization, as well as real-time access to the proximal hemisphere, is feasible and could improve the prenatal detection of fetal cerebral anomalies.


Assuntos
Pontos de Referência Anatômicos/diagnóstico por imagem , Encéfalo/diagnóstico por imagem , Malformações do Sistema Nervoso/diagnóstico por imagem , Ultrassonografia Pré-Natal/métodos , Mama/anormalidades , Estudos de Viabilidade , Feminino , Humanos , Hipertrofia , Gravidez , Estudos Prospectivos
3.
Fetal Diagn Ther ; 47(6): 514-518, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31931505

RESUMO

OBJECTIVE: To introduce visualization of the germinal matrix (GM), external angle of the frontal horn, and periventricular white matter while evaluating the anterior complex (AC) during basic ultrasound assessment of the fetal brain. CASE PRESENTATIONS: This is a retrospective observational study of healthy women with singleton pregnancies, with no increased risk of fetal central nervous system anomalies, attending routine ultrasound screening at 20-32 weeks' gestation. Seventeen cases are presented in which an abnormal aspect of the GM or external angle of the frontal horn or periventricular white matter on AC evaluation has allowed a prenatal diagnosis of peri-intraventricular hemorrhage, subependymal cysts, connatal cysts, periventricular venous hemorrhagic infarction, and white matter injury. CONCLUSION: An extended AC evaluation could significantly improve the -diagnosis of hemorrhagic/cystic/hypoxic-ischemic lesions during the performance of a basic ultrasound study of the fetal brain.


Assuntos
Encéfalo/diagnóstico por imagem , Encéfalo/embriologia , Ultrassonografia Pré-Natal , Encéfalo/anormalidades , Cistos do Sistema Nervoso Central/diagnóstico por imagem , Cistos do Sistema Nervoso Central/embriologia , Hemorragia Cerebral Intraventricular/diagnóstico por imagem , Hemorragia Cerebral Intraventricular/embriologia , Ventrículos Cerebrais/irrigação sanguínea , Ventrículos Cerebrais/diagnóstico por imagem , Ventrículos Cerebrais/embriologia , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Gravidez , Resultado da Gravidez , Estudos Retrospectivos
5.
Minerva Obstet Gynecol ; 75(1): 69-79, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36790399

RESUMO

INTRODUCTION: To perform a systematic review and meta-analysis of the diagnostic performance of the so-called Gynecologic Imaging and Report Data System (GI-RADS) for classifying adnexal masses. EVIDENCE ACQUISITION: A search for studies reporting about the use of GI-RADS system for classifying adnexal masses from January 2009 to December 2021 was performed in Medline (Pubmed), Google Scholar, Scopus, Cochrane, and Web of Science databases. Pooled sensitivity, specificity, positive and negative likelihood ratios and diagnostic odd ratio (DOR) were calculated. Studies' quality was evaluated using QUADAS-2. EVIDENCE SYNTHESIS: We identified 510 citations. Ultimately, 26 studies comprising 7350 masses were included. Mean prevalence of ovarian malignancy was 26%. The risk of bias was high in eight studies for domain "patient selection" and low for "index test," "reference test" domains for all studies. Overall, pooled estimated sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio and DOR of GI-RADS system for classifying adnexal masses were 94% (95% confidence interval [CI]=91-96%), 90% (95% CI=87-92%), 9.1 (95% CI=7.0-11.9), and 0.07 (95% CI=0.05-0.11), and 132 (95% CI=78-221), respectively. Heterogeneity was high for both sensitivity and specificity. Meta-regression showed that multiple observers and study's design explained this heterogeneity among studies. CONCLUSIONS: GI-RADS system has a good diagnostic performance for classifying adnexal masses.


Assuntos
Doenças dos Anexos , Neoplasias Ovarianas , Feminino , Humanos , Doenças dos Anexos/diagnóstico por imagem , Doenças dos Anexos/patologia , Neoplasias Ovarianas/diagnóstico por imagem , Neoplasias Ovarianas/epidemiologia , Sensibilidade e Especificidade , Diagnóstico por Imagem
6.
Rev. chil. obstet. ginecol. (En línea) ; Rev. chil. obstet. ginecol;89(1): 37-42, feb. 2024. tab, ilus
Artigo em Espanhol | LILACS | ID: biblio-1559719

RESUMO

Introducción y objetivo: Demostrar el valor del plano axial del complejo posterior, como apoyo a la detección antenatal de sintelencefalia, variante de holoprosencefalia. Método: Se incluyeron todas las pacientes con diagnóstico de sintelencefalia evaluadas desde el año 2008. En todos los casos se consignaron los datos clínicos, de neurosonografía (NSG), de resonancia magnética (RM) y genética. Resultados: Cuatro casos fueron diagnosticados en el segundo trimestre y en todos se realizó estudio genético y RM. Tres tuvieron en su evolución anomalías extra-SNC y dos de ellos alteraciones cromosómicas, una de ellas incompatible con la vida extrauterina. Lo hallazgos descritos en neuroimagen para esta afección fueron detectados en la NSG, con una excelente correlación con RM, ya fuera esta última realizada en periodo fetal o posnatal. Conclusión: El diagnóstico prenatal de variantes de holoprosencefalia es difícil, considerando la existencia de una fusión medial más acotada que en las formas clásicas. El presente estudio demuestra la utilidad del plano del complejo posterior para la sospecha diagnóstica de sintelencefalia.


Introduction and objective: To demonstrate the value of the axial plane of the posterior complex, as a clue for the antenatal detection of synthelencephaly, a variant of holoprosencephaly. Method: All patients diagnosed with syntelencephaly evaluated since 2008 were included. In all cases, clinical, neurosonography (NSG), magnetic resonance imaging (MRI) and genetic data were recorded. Results: Four cases were diagnosed in the second trimester and in all of them a genetic study and MRI were performed. Three had extra-CNS anomalies in their evolution and two of them chromosomal anomalies, one of them incompatible with extrauterine life. Neuroimaging findings described for this condition were detected by NSG, with an excellent correlation with MRI, whether the latter was performed in the fetal or postnatal period. Conclusion: The prenatal diagnosis of holoprosencephaly variants is difficult, considering the existence of a more limited medial fusion than in the classical forms. The present study demonstrates the usefulness of the posterior complex plane for the diagnostic suspicion of synthelencephaly.


Assuntos
Humanos , Feminino , Gravidez , Adulto , Adulto Jovem , Imageamento por Ressonância Magnética , Ecoencefalografia/métodos , Holoprosencefalia/diagnóstico por imagem , Diagnóstico Pré-Natal , Septo Pelúcido/diagnóstico por imagem , Estudos Retrospectivos
7.
Rev. chil. obstet. ginecol. (En línea) ; Rev. chil. obstet. ginecol;88(6): 351-358, dic. 2023. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-1530033

RESUMO

Objetivo: Reportar el resultado a largo plazo de una serie de fetos con agenesia del septum pellucidum aislada (ASP), con medición de su quiasma óptico mediante neurosonografía fetal (NSG). Método: Se incluyeron todas las pacientes con ASP y NSG evaluadas desde el año 2008 a la fecha y con seguimiento hasta su edad escolar. En todos los casos se consignaron los datos clínicos de NSG y de resonancia magnética (RM), cuando esta se realizó. Se entrevistó telefónicamente a los padres. Resultados: Nueve pacientes cumplieron los criterios: cuatro con displasia septo-óptica (DSO) (rango de seguimiento: 5-14 años) y cinco sin DSO (rango de seguimiento: 7-10 años). Un décimo caso se excluyó por tener solo 6 meses de seguimiento. Ninguna de las ASP tuvo otra anomalía detectada en su seguimiento. Ninguno de los casos con DSO tuvo alteración del tamaño de su quiasma óptico en la NSG ni anormalidad en la vía óptica en la RM. Conclusiones: En nuestra población, el riesgo residual de DSO frente a ASP es del 44,4%. En el seguimiento, nuestra definición de ASP por NSG no tuvo falsos negativos con relación a otras anomalías de aparición posnatal, a excepción de la DSO.


Objective: To report the long-term outcome of a series of fetuses with isolated septum pellucidum agenesis (ASP) with measurement of their optic chiasm by fetal neurosonography (NSG). Method: All patients with ASP and NSG evaluated from 2008 to date and with follow-up until their school age were included. In all cases, clinical, NSG and magnetic resonance imaging (MRI) data were recorded. Parents were interviewed by telephone. Results: Nine patients met the criteria: four with septo-optic dysplasia (SOD) (follow-up range: 5-14 years) and five without SOD (follow-up range: 7-10 years). A tenth case was excluded because only 6 months of follow-up. None of the ASP cases had another anomaly detected in their follow-up. None of the cases with DSO had anomaly of the size of their optic chiasm on NSG or abnormality in the optical pathway in the MRI. Conclusions: In our population, the residual risk of DSO versus ASP is 44.4%. At follow-up, our NSG definition of ASP had no false negatives in relation to other postnatal-onset anomalies, except for SOD.


Assuntos
Humanos , Masculino , Feminino , Gravidez , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Adulto Jovem , Quiasma Óptico/diagnóstico por imagem , Septo Pelúcido/anormalidades , Septo Pelúcido/diagnóstico por imagem , Displasia Septo-Óptica/diagnóstico por imagem , Imageamento por Ressonância Magnética , Estudos Retrospectivos , Seguimentos , Ultrassonografia Pré-Natal , Feto
8.
Rev. chil. obstet. ginecol. (En línea) ; Rev. chil. obstet. ginecol;88(5): 278-285, oct. 2023. tab, ilus
Artigo em Espanhol | LILACS | ID: biblio-1530025

RESUMO

Introducción: Los quistes interhemisféricos asociados a agenesia del cuerpo calloso constituyen un grupo infrecuente y heterogéneo de anomalías del SNC. Objetivo: Reportar nuestra experiencia en quistes interhemisféricos asociados a agenesia del cuerpo calloso (QIH/ACC), haciendo énfasis en sus características en la neurosonografía (NSG), su comparación con la resonancia magnética (RM) y su evolución clínica posterior. Método: Se incluyeron todas las pacientes con QIH/ACC evaluadas desde el año 2008. En todos los casos se consignaron los datos clínicos, de NSG y de RM cuando se realizó. Se entrevistó telefónicamente a los padres. Resultados: Fueron seleccionados 9 casos con QIH/ACC. De ellos, 5 fueron quistes tipo 1, 3 tuvieron anomalías asociadas y en los 3 hubo una anomalía genética patogénica. Cuatro casos fueron quistes tipo 2, 3 de ellos con un patrón NSG sugerente de síndrome de Aicardi. Hubo una excelente correlación entre NSG y RM, ya fuera esta última realizada ante- o posnatal, particularmente con relación a las malformaciones del desarrollo cortical asociadas al QIH/ACC. Conclusiones: En comparación con la RM y el resultado final, hubo alta concordancia con lo diagnosticado en la NSG, en especial en cuanto a malformaciones del desarrollo cortical asociadas, lo que añade valor al método diagnóstico que ofrecemos a nuestra población consultante.


Background: Callosal agenesis associated with interhemispheric cysts correspond to a rare and heterogenous group of CNS anomalies. Objective: To report our experience in interhemispheric cysts associated with agenesis of the corpus callosum (QIH/ACC), emphasizing its characteristics in neurosonography (NSG), its comparison with magnetic resonance imaging (MRI) and its subsequent clinical evolution. Method: All patients with QIH/ACC evaluated since 2008 were included. In all cases, clinical, NSG and MRI data were recorded when performed. The parents were interviewed by telephone. Results: A total of 9 cases were selected with QIH/ACC. 5 cases were type 1 cysts, 3 of them had associated abnormalities and in all 3 there was a pathogenic genetic anomaly. 4 cases were type 2 cysts, 3 of them with an NSG pattern suggestive of Aicardi syndrome. There was an excellent correlation between NSG and MRI, either before or postnatally, particularly in relation to cortical developmental malformations associated with QIH/ACC. Conclusions: Compared to MRI and the final result, there was high agreement with what was diagnosed in NSG, especially in what corresponds to associated cortical developmental malformations, which adds value to the diagnostic method we offer to our consulting population.


Assuntos
Humanos , Masculino , Feminino , Gravidez , Cistos/diagnóstico por imagem , Agenesia do Corpo Caloso/diagnóstico por imagem , Estudos Retrospectivos , Ultrassonografia Pré-Natal , Síndrome de Aicardi
9.
Rev. chil. obstet. ginecol. (En línea) ; Rev. chil. obstet. ginecol;87(2): 97-103, abr. 2022. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-1388725

RESUMO

OBJETIVO: Analizar la implementación de la prueba rápida de reacción en cadena de la polimerasa cuantitativa y fluorescente (QF-PCR) para la detección de aneuploidías. MÉTODO: Se incluyeron todas las pacientes que se realizaron una QF-PCR entre septiembre de 2017 y mayo de 2021. En todos los casos se consignaron los datos clínicos, ecográficos y de laboratorio, y se efectuó un seguimiento de quienes se realizaron además cariograma y su resultado fue normal. RESULTADOS: Se realizaron 213 procedimientos invasivos genéticos prenatales, siendo 72 para detección rápida de aneuploidía mediante QF-PCR. El promedio de edad de las madres con QF-PCR fue de 37 años y 48 pacientes (67%) tenían menos de 15 semanas de gestación. La QF-PCR demostró aneuploidía de los cromosomas 18, 13 y de triploidía en 21 de 49 casos informados como anormales. De los 22 casos sin sugerencia de alteración, 17 accedieron a proseguir el estudio con cariotipo, que resultó anormal en 6 casos. Hubo 4 casos de discordancia entre la QF-PCR y el cariotipo, que pudo afectar el manejo clínico de la gestación. En 25/72 casos (34,7%) la aneuploidía era letal. CONCLUSIONES: Considerando la necesidad de tener un diagnóstico rápido, pero también completo y que permita un consejo genético apropiado, debería integrarse la QF-PCR a un protocolo de diagnóstico que considere variables clínicas y ecográficas.


OBJECTIVE: To analyze the performance of QF-PCR test for the detection of aneuploidies. METHOD: All patients who underwent QF-PCR from September 2017 to May 2021, were included. Clinical, ultrasound and laboratory data were recorded in all cases, as well as follow-up of the cases, including those performing karyotype and the result was normal. RESULTS: 213 prenatal genetic invasive procedures were performed in the study period, 72 for rapid detection of aneuploidy by QF-PCR. 48 patients (67%) were less than 15 weeks at the time of ultrasound diagnosis. The QF-PCR test demonstrated aneuploidy of chromosomes 18, 13, and triploidy in 21/49 cases reported as abnormal. Of the cases without suggestion of alteration (22), 17 agreed to continue the study with a karyotype, which was abnormal in 6 cases. There were 4 cases of discrepancy between QF-PCR and karyotype, which could affect the clinical management of pregnancy. 25/72 cases (34. 7%) corresponded to lethal aneuploidy. CONCLUSIONS: Our results justify the use of QF-PCR. Considering the need to have a rapid diagnosis, but also complete and that allows appropriate genetic counseling, it is that QF-PCR should be integrated into a protocol that considers clinical and ultrasound variables.


Assuntos
Humanos , Feminino , Gravidez , Adulto , Diagnóstico Pré-Natal/métodos , Reação em Cadeia da Polimerase/métodos , Aneuploidia , Aberrações Cromossômicas , Análise Citogenética , Aconselhamento Genético
10.
Rev. chil. obstet. ginecol. (En línea) ; Rev. chil. obstet. ginecol;87(4): 266-272, ago. 2022. tab
Artigo em Espanhol | LILACS | ID: biblio-1407852

RESUMO

Resumen Objetivo: Describir y analizar los hallazgos ecográficos en 97 fetos portadores de síndrome de Down (SD) confirmado. Método: Se incluyeron todas las gestantes con diagnóstico prenatal de SD de nuestro centro, realizado por cariograma o reacción en cadena de la polimerasa cuantitativa fluorescente para aneuploidía. Se analizaron los informes genéticos y ecográficos, y se realizó un seguimiento posnatal. Resultados: De los 97 casos de SD, el 73% de los diagnósticos fueron entre las 11 y 14 semanas. El promedio de edad de las madres fue de 35,7 años. El 83% de los fetos con SD, evaluados a las 11-14 semanas, tuvieron una translucencia nucal ≥ 3,5 mm. Del total de los casos analizados, el 33% fueron portadores de una cardiopatía congénita, correspondiendo el 58% de estas a defectos mayores, principalmente anomalías del tabique auriculoventricular. Un 7,6% de los casos terminaron como mortinato, principalmente durante el tercer trimestre. Conclusiones: El ultrasonido es una herramienta muy sensible para la sospecha prenatal de SD y la detección de sus anomalías asociadas. Consideramos que la información aportada será útil para programar estrategias de pesquisa, organizar el control perinatal y precisar el consejo a los padres de fetos portadores de esta condición.


Abstract Objective: To describe and analyze the ultrasound findings in 97 fetuses with confirmed Down syndrome (DS). Method: All pregnant women with prenatal diagnosis of DS in our center, performed by karyotype or quantitative fluorescent polymerase chain reaction for aneuploidy, were included. Genetic and ultrasound reports were analyzed, as well as postnatal follow-up. Results: Of the 97 cases of DS, 73% of the diagnoses were between 11-14 weeks. The average age of the mothers was 35.7 years. 83% of our fetuses with DS, evaluated between 11-14 weeks, had a nuchal translucency ≥ 3.5 mm. Of the total of the fetuses analyzed, 33% were carriers of congenital heart disease, 58% of these correspond to a major defect, mainly anomalies of the atrioventricular septum. 7.6% of cases ended as stillbirth, mainly during the third trimester. Conclusions: Ultrasound is a very sensitive tool for prenatal suspicion of DS and the detection of its associated abnormalities. We believe that the information provided will be useful to program screening strategies, organize perinatal control and to counselling parents of fetuses carrying this condition.


Assuntos
Humanos , Feminino , Gravidez , Recém-Nascido , Ultrassonografia Pré-Natal/métodos , Síndrome de Down/genética , Síndrome de Down/diagnóstico por imagem , Doenças Fetais/genética , Doenças Fetais/diagnóstico por imagem , Fenótipo , Estudos Transversais , Estudos Retrospectivos , Seguimentos , Medição da Translucência Nucal , Mortalidade Fetal , Feto/anormalidades , Cardiopatias Congênitas/diagnóstico por imagem
11.
Rev. obstet. ginecol. Venezuela ; 69(4): 231-238, dic. 2009. tab
Artigo em Espanhol | LILACS | ID: lil-631402

RESUMO

Evaluar la ooforectomía como medida profiláctica para la disminución del riesgo de cáncer de ovario en mujeres con antecedente de histerectomía y conservación de ovarios, debida a patología benigna, que consultaron desde enero 2000 a diciembre 2006. Se realizó un estudio retrospectivo observacional de tipo descriptivo y transversal, mediante la revisión de historias médicas, determinando el sistema de variables y registrando los datos en una ficha preelaborada, siendo procesados estadísticamente con el programa SPSS 12. Instituto Autónomo Hospital Universitario de Los Andes. De un total de 1030 histerectomías en un período de 7 años, 603 fueron por causa benigna, conservando uno o ambos ovarios en 423. Además, se revisaron 490 historias con diagnóstico de tumor de ovario, de las cuales 35 pacientes tuvieron antecedente de histerectomía (durante el mismo período de años, pero con 1 año de diferencia en más, para dar margen a la aparición del tumor), en las que 30 (18 institucionales) presentaron reporte histopatológico a su resolución, posterior al diagnóstico, 68,6: por ciento resultaron benignos, 17,1 por ciento malignos, y 14,3 por ciento quedó sin conocerse. Se determinó que el riesgo de cáncer de ovario en las pacientes a las que se les conserva los ovarios en esta institución, corresponde entre el 0,23 por ciento - 1,37 por ciento, por lo que serían necesarias 423 ooforectomías rutinarias para prevenir 1 caso de cáncer de ovario, en un lapso que correspondió a 7 años. La ooforectomía profiláctica no se justifica según los hallazgos de esta investigación


To evaluate oophorectomy as prophylactic measure to reduce ovarian cancer in women with history of hysterectomy and ovarian conservation secondary to a benign cause, who consulted from January 2000 to December 2006. A retrospective observational, descriptive and transversal study was performed by reviewing medical charts, and gathering the data in a designed collection form. Statistical analysis was made by using SPSS 12 software. Instituto Autonomo Hospital Universitario de Los Andes. From a total of 1030 hysterectomies reviewed in a 7 year period, 603 were performed secondary to a benign cause; and in 423 of them one or both ovaries were not removed. From 490 cases of patients with diagnosis of ovarian tumor, only 35 patients had history of previous hysterectomy. Out of these 35 patients, 30 (18 institutional) patients had biopsy report of the ovarian tumor after diagnosis 68.6 percent were benign, 17.1 percent were malignant, and 14.3 percent were undetermined. It was established that the risk of ovarian cancer in patients who underwent hysterectomy due to a benign cause with ovarian conservation was 0.23 percent to 1.37 percent. 423 routine oophorectomies would be necessary to prevent one case of ovarian cancer (number needed to treat: 423). Prophylactic oophorectomy is not justified for this purpose


Assuntos
Humanos , Feminino , Histerectomia Vaginal/métodos , Neoplasias Ovarianas/diagnóstico , Neoplasias Ovarianas/prevenção & controle , Ovariectomia/métodos , Fatores de Risco
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