Detalhe da pesquisa
1.
Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors.
Molecules
; 29(11)2024 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38893570
2.
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity.
Bioorg Chem
; 140: 106794, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37659146
3.
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands.
Molecules
; 28(8)2023 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37110664
4.
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands.
Molecules
; 28(12)2023 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37375382
5.
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.
Bioorg Med Chem Lett
; 72: 128860, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35724925
6.
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain.
Molecules
; 27(16)2022 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36014375
7.
Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity.
Molecules
; 26(13)2021 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34202711
8.
Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands.
Int J Mol Sci
; 20(3)2019 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30678129
9.
Activated protein C ß-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.
Blood
; 126(7): 915-9, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26084674
10.
Designing drugs optimized for both blood-brain barrier permeation and intra-cerebral partition.
Expert Opin Drug Discov
; 19(3): 317-329, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38145409
11.
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients.
Biomed Pharmacother
; 174: 116537, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579402
12.
Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity.
RSC Med Chem
; 14(9): 1734-1742, 2023 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37731701
13.
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands.
ACS Chem Neurosci
; 14(10): 1845-1858, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37155827
14.
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
J Med Chem
; 66(16): 11447-11463, 2023 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37535861
15.
Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.
ACS Infect Dis
; 9(8): 1470-1487, 2023 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37417544
16.
Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain.
J Med Chem
; 66(14): 9658-9683, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37418295
17.
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus.
ACS Infect Dis
; 9(12): 2423-2435, 2023 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37991879
18.
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.
Eur J Med Chem
; 230: 114091, 2022 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35016113
19.
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties.
ACS Chem Neurosci
; 13(1): 1-15, 2022 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34908391
20.
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma.
J Med Chem
; 64(18): 13622-13632, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34477381