Detalhe da pesquisa
1.
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.
Eur Respir J
; 62(3)2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37442582
2.
Wild-type sTREM2 blocks Aß aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aß aggregation.
J Biol Chem
; 296: 100631, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33823153
3.
An exTREMe disruption in Alzheimer's cleanup.
J Biol Chem
; 293(32): 12647-12648, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30097493
4.
Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1.
Nature
; 504(7479): 301-5, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24291792
5.
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.
Mol Cell
; 44(6): 997-1004, 2011 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22195972
6.
Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.
bioRxiv
; 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712280
7.
A simeprevir-inducible molecular switch for the control of cell and gene therapies.
Nat Commun
; 14(1): 7753, 2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38012128
8.
Therapeutic Monoclonal Antibodies to Complex Membrane Protein Targets: Antigen Generation and Antibody Discovery Strategies.
BioDrugs
; 32(4): 339-355, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29934752
9.
TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
EMBO Mol Med
; 9(10): 1366-1378, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28855301
10.
Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.
Cell Metab
; 24(5): 740-752, 2016 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27923773
11.
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.
Neuron
; 88(4): 678-90, 2015 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26526393
12.
Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.
Structure
; 22(1): 125-35, 2014 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24210759
13.
Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules.
EMBO J
; 25(8): 1635-45, 2006 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16601694
14.
Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.
J Biol Chem
; 279(51): 53840-7, 2004 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15465811