Detalhe da pesquisa
1.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Bioorg Med Chem Lett
; 20(20): 6088-92, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20832306
2.
Highly functionalized 7-azaindoles as selective PPAR gamma modulators.
Bioorg Med Chem Lett
; 18(17): 4798-801, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18701276
3.
Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: A comparison with PPAR gamma agonism.
Endocrinology
; 147(9): 4252-62, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16728496
4.
Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.
J Med Chem
; 48(7): 2262-5, 2005 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15801817
5.
Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
J Med Chem
; 48(13): 4457-68, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974597
6.
Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.
Mol Endocrinol
; 17(4): 662-76, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12554792
7.
Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists.
Endocrinology
; 143(6): 2106-18, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12021175
8.
A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis.
Endocrinology
; 145(4): 1640-8, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-14701675
9.
(2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents.
J Med Chem
; 47(12): 3255-63, 2004 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15163205
10.
Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.
J Med Chem
; 54(24): 8541-54, 2011 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22070604
11.
Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.
J Med Chem
; 52(14): 4443-53, 2009 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19530681
12.
Benzoyl 2-methyl indoles as selective PPARgamma modulators.
Bioorg Med Chem Lett
; 15(2): 357-62, 2005 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15603954
13.
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.
Bioorg Med Chem Lett
; 13(5): 931-5, 2003 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12617924
14.
MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities.
Biochem Biophys Res Commun
; 318(2): 323-8, 2004 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15120604
15.
5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents.
Bioorg Med Chem Lett
; 13(16): 2795-8, 2003 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12873517
16.
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Bioorg Med Chem Lett
; 13(19): 3185-90, 2003 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12951090
17.
5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.
Bioorg Med Chem Lett
; 13(10): 1801-4, 2003 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12729668
18.
Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists.
Bioorg Med Chem Lett
; 13(20): 3541-4, 2003 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-14505666