1.
N Engl J Med
; 356(23): 2427-9; author reply 2427-9, 2007 Jun 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17563925
2.
N Engl J Med
; 354(5): 528-30; author reply 528-30, 2006 Feb 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16456941
3.
Curr Infect Dis Rep
; 9(2): 110-5, 2007 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17324347
RESUMO
Both diabetes and chronic hepatitis C virus (HCV) infection are common conditions that often coexist in the same subject. Studies seem to confirm the presence of an association between them. Mechanisms leading to HCV-induced insulin resistance and glucose intolerance are beginning to be elucidated. Insulin resistance in the setting of chronic HCV infection could be related etiologically to viral factors but is also often seen with concomitant nonalcoholic fatty liver disease, the hepatic manifestation of the metabolic syndrome. Insulin resistance decreases the likelihood of response to interferon-based therapies and may be an independent risk factor for the progression of HCV-related liver disease.