Left ventricular aneurysm in an adult patient with mucopolysaccharidosis type I: comment on pathogenesis of a novel complication.

Mucopolysaccharidosis type I (MPS I) is a rare autosomal recessive disease caused by deficiency of the lysosomal enzyme alpha-L-iduronidase. This enzyme is involved in the degradation of the glycosaminoglycans (GAGs) dermatan and heparan sulphate and its deficiency results in the accumulation of GAGs and a progressive multisystem disease. Cardiac involvement is common in MPS patients and usually consists of progressive valvular thickening with incompetence and cardiomyopathy. We present an attenuated MPS I patient with a primary apical left ventricular aneurysm not associated with ischemia. We speculate that the defect in GAG catabolism leads not only to the storage of GAGs but also to alterations of the myocardial extracellular matrix. The latter ultimately being responsible for the formation of the aneurysm. This case emphasizes the importance of careful surveillance for cardiac lesions in MPS patients.

A shared egg donor program: which is the minimum number of oocytes to be allocated?

PURPOSE: To evaluate which is the minimum number of oocytes to be allocated to each recipient in a shared egg donor program. METHODS: We analyzed 953 recipients that received at least 4 metaphase II (MII) oocytes in the period 2006-2008. We retrospectively divided the recipients according to the number of MII oocytes actually received. RESULTS: No statistically significant differences were found among the analyzed strata in clinical pregnancy rate (A:43.7%; B:45.6%; C:48.6%; D:45.5%; E:53%, P=NS) and miscarriage rate. However, the rate of top quality transferred embryos, and the embryo freezing rate were significantly higher among those recipients that received 7 or more mature eggs. CONCLUSIONS: After a large sample was analyzed, no significant differences in fresh embryo transfer outcome were encountered when a different number of oocytes was allocated. A minimum of 4 MII oocytes seems to achieve satisfactory pregnancy rates in our shared egg donor program.

Frecuencia de la contaminación de la leche disponible en el Valle de México con estreptomicina, tetraciclina y penicilina / Frecuency of contamination of milk with streptomicine tetracicline and peniciline in Mexico City

Este trabajo se efectuó con el objeto de establecer la magnitud de la contaminación con resíduos de antibióticos de las leches comerciales disponibles en el Valle de México. Se obtuvieron 125 muestras de leche de diferentes marcas comerciales durante el período marzo-julio de 1985 y fueron analizadas para penicilina, estreptomicina y tetraciclina, siguiendo los métodos microbiológicos de cilindro en placa. Solamente el 9.6% de las muestras resultaron libres de antibióticos, el 25% contenían penicilina, el 60% estreptomicina, el 70% tetraciclina y más del 80% contenían 2 o los 3 antibióticos. Los niveles promedios encontrados para penicilina, estreptomicina y tetraciclina fueron 0.11 UI/ml, 0.02 microng/ml y 0.07 microng/ml, respectivamente. Ninguna marca de leche resultó negativa en todas las muestras y las 8 muestras de leche para bebé también resultados positivas a uno o a dos de los antibióticos estudiados. Aunque los niveles encontrados de penicilina, estroptomicina y tetraciclina son muy bajos, su ingestión diaria a través de la leche puede tener repercusiones en la salud pública, especialmente en los niños