Detalhe da pesquisa
1.
Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels.
Cell
; 179(2): 340-354, 2019 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585078
2.
SENSAAS-Flex: a joint optimization approach for aligning 3D shapes and exploring the molecular conformation space.
Bioinformatics
; 40(3)2024 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38383065
3.
Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion.
Cell Mol Life Sci
; 80(5): 124, 2023 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37071200
4.
Black mamba venom peptides target acid-sensing ion channels to abolish pain.
Nature
; 490(7421): 552-5, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23034652
5.
Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.
J Biol Chem
; 291(6): 2616-29, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26680001
6.
Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1.
J Pharmacol Exp Ther
; 357(2): 281-92, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937021
7.
Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases.
J Enzyme Inhib Med Chem
; 31(sup2): 148-161, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27424662
8.
Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a.
J Biol Chem
; 289(19): 13363-73, 2014 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695733
9.
Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex.
J Comput Aided Mol Des
; 29(6): 525-39, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25822046
10.
TWIK1, a unique background channel with variable ion selectivity.
Proc Natl Acad Sci U S A
; 109(14): 5499-504, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431633
11.
Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.
J Biol Chem
; 288(49): 35081-92, 2013 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24163367
12.
Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active.
Biochem J
; 450(1): 159-67, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23198904
13.
Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.
Hum Mol Genet
; 20(10): 1873-85, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21330300
14.
e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design.
Bioinformatics
; 28(11): 1540-1, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22539672
15.
Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells.
J Biol Chem
; 286(42): 36509-21, 2011 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21878635
16.
e-LEA3D: a computational-aided drug design web server.
Nucleic Acids Res
; 38(Web Server issue): W615-21, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20444867
17.
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.
Proc Natl Acad Sci U S A
; 106(34): 14628-33, 2009 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19667202
18.
Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a.
Neuropharmacology
; 185: 108453, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33450275
19.
sensaas: Shape-based Alignment by Registration of Colored Point-based Surfaces.
Mol Inform
; 39(8): e2000081, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32573978
20.
Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma.
Cancers (Basel)
; 12(6)2020 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32526884