RESUMO
The experimental paradigm reported here provides a useful animal model with which to further study the effects of regional electrostimulation and its possible relationship with electrical acupuncture. What similarities there may be between electrical acupuncture and the technique of regional electrocerebral stimulation used for production of electrosleep and electronarcosis in animals and man (Wageneder et al., 1966) remain to be elucidated. Further research studies, both clinical and basic, are clearly needed to answer some of the questions relating to the safety, efficacy, and possible mechanisms by which a technique such as electrical acupuncture may exert its effects.
Assuntos
Terapia por Acupuntura , Modelos Animais de Doenças , Orelha , Dependência de Morfina/terapia , Síndrome de Abstinência a Substâncias/terapia , Animais , Comportamento Animal/efeitos dos fármacos , Estimulação Elétrica , Humanos , Masculino , Dependência de Morfina/tratamento farmacológico , Atividade Motora/efeitos dos fármacos , Naloxona/uso terapêutico , RatosRESUMO
This study investigated biochemical substrates of the continuous stimulation effect, i.e. the developmental phenomenon whereby continuous stimulation depresses arousal level. Neonatal rats were injected intracisternally with 6-hydroxydopamine. Motility, heart rate, and brain amines were measured in theses animals, as well as in injected and noninjected control animals, at 14 and 28 days of age in an own-control design with and without continuous auditory stimulation. Brain norepinephrine was significantly and inversely related to the magnitude of the continuous stimulation effect and experimental-control differences increased with age. These results indicate that an intact catecholaminergic system is necessary for the mediation of increased arousal during stimulation.
Assuntos
Animais Recém-Nascidos/fisiologia , Percepção Auditiva/fisiologia , Hidroxidopaminas/farmacologia , Estimulação Acústica , Fatores Etários , Animais , Encéfalo/metabolismo , Química Encefálica , Dopamina/metabolismo , Frequência Cardíaca , Atividade Motora/fisiologia , Norepinefrina/metabolismo , Norepinefrina/fisiologia , Psicofisiologia , Ratos , Serotonina/metabolismoRESUMO
The experimental paradigm reported here provides a useful animal model with which to further study the effects of regional electrostimulation and its possible relationship with electrical acupuncture. What similarities there may be between electrical acupuncture and the technique of regional electrocerebral stimulation used for production of electrosleep and electronarcosis in animals and man remain to be elucidated. Further research studies, both clinical and basic, are clearly needed to answer some of the questions relating to the safety, efficacy, and possible mechanisms by which a technique such as electrical acupuncture may exert its effects.