Detalhe da pesquisa
1.
Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice.
Regul Toxicol Pharmacol
; 126: 105029, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34455009
2.
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Regul Toxicol Pharmacol
; 113: 104624, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32126256
3.
An innovative investigative approach to characterize the effects observed in a combined fertility study in male and female rats.
Regul Toxicol Pharmacol
; 95: 339-347, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29635059
4.
Vehicle Systems and Excipients Used in Minipig Drug Development Studies.
Toxicol Pathol
; 44(3): 367-72, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26674803
5.
Organ data from the developing Göttingen minipig: first steps towards a juvenile PBPK model.
J Pharmacokinet Pharmacodyn
; 43(2): 179-90, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26687458
6.
Regulatory Forum Opinion Piece: Carcinogen Risk Assessment: The Move from Screens to Science.
Toxicol Pathol
; 43(8): 1064-73, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26296629
7.
The development of myelin in the brain of the juvenile rat.
Toxicol Pathol
; 42(5): 913-22, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24129760
8.
Juvenile toxicity: are we asking the right questions?
Toxicol Pathol
; 40(5): 830-7, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22407308
9.
Revisiting alternative approaches to the assessment of carcinogenic risk.
Toxicol Pathol
; 38(2): 324-7, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20124498
10.
Consideration of the Development of the Gastrointestinal Tract in the Choice of Species for Regulatory Juvenile Studies.
Birth Defects Res
; 110(1): 56-62, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28872769
11.
Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.
Front Pharmacol
; 8: 531, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28848445
12.
Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.
Cancer Res
; 77(5): 1127-1141, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096174
13.
Vigabatrin-induced CNS changes in juvenile rats: Induction, progression and recovery of myelin-related changes.
Neurotoxicology
; 46: 137-44, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25554247