Detalhe da pesquisa
1.
A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
J Biol Chem
; 298(7): 102119, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35691342
2.
Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
J Biol Chem
; 296: 100173, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33303633
3.
High avidity drives the interaction between the streptococcal C1 phage endolysin, PlyC, with the cell surface carbohydrates of Group A Streptococcus.
Mol Microbiol
; 116(2): 397-415, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33756056
4.
Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases.
Biochem J
; 478(13): 2697-2713, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34133730
5.
X-ray crystal structure and specificity of the Toxoplasma gondii ME49 TgAPN2.
Biochem J
; 477(19): 3819-3832, 2020 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32926129
6.
X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2.
Proteins
; 85(5): 945-950, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27936485
7.
Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.
Biochim Biophys Acta Proteins Proteom
; 1865(11 Pt A): 1336-1347, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28844738
8.
Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.
Biochem J
; 473(19): 3189-204, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27462122
9.
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
Proteins
; 83(4): 789-95, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25645579
10.
From crystal to compound: structure-based antimalarial drug discovery.
Biochem J
; 461(3): 349-69, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25008945
11.
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
Res Sq
; 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38746424
12.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
mBio
; 15(6): e0096624, 2024 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38717141
13.
Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Eur J Med Chem
; 248: 115051, 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36634455
14.
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.
Biochem J
; 431(1): 51-61, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20642456
15.
A Structure-Activity Relationship Study of Novel Hydroxamic Acid Inhibitors around the S1 Subsite of Human Aminopeptidase N.
ChemMedChem
; 16(1): 234-249, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32945135
16.
Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.
Biochem J
; 422(3): 463-71, 2009 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19570037
17.
M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment.
Biochimie
; 166: 38-51, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30654132
18.
Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection.
Nat Microbiol
; 4(12): 2237-2245, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31406331
19.
Identification of the Binding Site of Apical Membrane Antigenâ 1 (AMA1) Inhibitors Using a Paramagnetic Probe.
ChemMedChem
; 14(5): 603-612, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30653832
20.
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.
J Med Chem
; 62(2): 622-640, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30537832