[Assessment of the disability weight for chronic schistosomiasis japonica in lake region].

OBJECTIVE: To estimate a suitable disability weight for chronic schistosomiasis japonica in a lake area of China. METHODS: A total of 219 chronic schistosomiasis patients from surveillance sites in Yangxin County of Hubei Province received questionnairing. The age- and sex-specific disability weights of chronic schistosomiasis were estimated based on the six classes of disability severity identified by Global Burden of Disease (GBD). All data was managed by Epidata 3.1. Statistical analysis was performed using SAS8.1. Rank sum test and Kruskal-Wallis test were used to examine the differences between disability weights. Pair-wise comparison was done by Nemenyi method. Multifactor logistic regression was used to analyze the risk factors of disability weight. RESULTS: The average disability weight was 0.122, and age-specific weight ranged from 0.020 to 0.280. The disability weight increased with age. Significant differences were found among different age groups (chi2=152.590, P<0.01). The disability weight of males (0.103) was significantly lower (Z=2.405, P<0.05) than that of females (0.147). Multi-factor logistic regression models indicated that the disability weight was significantly associated with age (OR=1.173, 95% CI: 1.130-1.217), and income level was a protective factor (OR=0.497, 95% CI: 0.319-0.775), while age was a confounding factor. CONCLUSION: An average disability weight of 0.122 for chronic schistosomiasis japonica indicates that 1/8 healthy year has lost for each survived life year of the patients, higher than the data of GBD.

[Study on family and economic burden caused by chronic Schistosomiasis japonica].

OBJECTIVE: To evaluate the family and economic burden of chronic Schistosomiasis japonica. METHODS: Relevant information on 226 chronic schistosomiasis patients from four surveillance sites in Yangxin county was collected. A questionnaire survey was conducted on 219 of them who agreed to corporate. Family burden was estimated with standard Family Burden Scale of Disease (FBS). Direct economic burden was calculated by questionnaire survey. Human capital method combined with Years Lived with Disability (YLDs) was adopted to evaluate the indirect economic burden. RESULTS: The positive rates on the dimensions of family economic burden and family entertainment were 54.8 percent and 47.0 percent respectively. The remaining dimensions were lower than 40.0 percent. Results of the questionnaire survey among 219 chronic Schistosomiasis patients showed that the total economic burden was 353,480.59 Chinese Yuan, which was 1614.07 Yuan per person. The direct and indirect economic burden were 61,679 and 291,801.59 Yuan respectively. The average direct and indirect economic burden when counted on money losses, were 281.64 and 1332.43 Yuan per person, respectively. CONCLUSION: The family burden caused by chronic Schistosomiasis japonica was serious, economically in particular. With regard to the income level of local residents, the economic burden of chronic Schistosomiasis was heavy to every household with indirect economic burden accounted for major proportion, suggesting close attention to be paid.

[Study on the reliability, validity and sensitivity of a Family Burden Scale used for evaluation on schistosomiasis].

OBJECTIVE: To evaluate the reliability, validity and sensitivity of a Family Burden Scale (FBS) of disease used on schistosomiasis. METHODS: 224 schistosomiasis patients were investigated, using the FBS. Reliability was estimated by Cronbach's alpha coefficient and split-half reliability. Validity was tested by factor analysis. Sensitivity was evaluated by comparison of patients with different income levels. RESULTS: The Cronbach's alpha coefficient was 0.874 and split-half reliability was 0.939 for FBS, respectively. Most values of Cronbach's alpha and split-half reliability for each component of scale were above 0.70. Construct validity was appraised by factor analysis, and 6 factors were identified. These factors could explain 66.76% of the total variance. Patients with different income levels showed significant difference in terms of family burden for schistosomiasis (P < 0.001). CONCLUSION: This FBS appeared to have satisfactory reliability, validity and sensitivity and could be used in evaluating family burden of schistosomiasis patients.

[Study on the factors influencing the quality of life among patients with malignant lymphoma].

OBJECTIVE: To measure and assess the quality of life (QOL) and to explore the influencing factors on patients with malignant lymphoma. METHODS: QOL of 110 patients with malignant lymphoma were marked using EORTC QLQ-C30 short form, and multiple linear regression models were used to study the main factors influencing the QOL of patients with malignant lymphoma on five functional scales (physical, role, cognitive, emotional, and social) and the total scores. RESULTS: The influencing factors of quality of life on patients with malignant lymphoma appeared to be: history of relapse, refraining from smoking, older age, educational level, space for living, exercises, medical care system, and available health care programs. Relapse (beta = 5.997, P= 0.020) and refraining from smoking (beta = -6.526, P= 0.006) were associated with total QOL scores, educational level (beta = -2.144, P= 0.057), History of relapse (beta = 5.857, P = 0.003) was associated with total functional scales while exercises (beta= -0.771, P = 0.097) and refraining from smoking (beta= -4.106, P = 0.005) were with physical scales, refraining from smoking (beta = -4.644,P = 0.008) and older age (beta = 0.989, P= 0.029) were with role scales, relapse (beta = 14.035, P= 0.001) and older age (beta = 2.230, P= 0.023) were with cognitive scales, relapse (beta = 8.500, P= 0.031) and living space (beta = - 3.054, P= 0.0901) were with emotional scales and medical care system and available health care programs (beta = -6.577, P= 0.018) were with social scales respectively. CONCLUSION: Factors as prevention of relapse, correct cognition on malignant lymphoma, reasonable exercise, refrain from bad habits, improving medical care system could all increase the functions of malignant lymphoma patient, and to improve their quality of life.

[Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis].

OBJECTIVE: To evaluate the relationship between circulating levels of insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3) and colorectal cancer. METHODS: A meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed. RESULTS: The pooled odds ratio (OR) of IGF-1 and IGFBP-3 were 1.56 (95% CI: 1.14-2.13) and 0.78 (95% CI: 0.43-1.44) respectively. According to the results from different measurements (enzyme-linked immunoabsorbent assay and immunoradiometric assay), the pooled OR were 1.92 and 1.23 for IGF-1, 0.46 and 1.44 for IGFBP-3 respectively. CONCLUSION: High serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used, but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion.