RESUMO
The onset of growth retardation was investigated in fetal lambs following experimental infection of pregnant ewes with Border Disease virus (BDV) on day 53 of pregnancy. Fetuses from control and infected ewes were harvested at weekly intervals between day 60 and day 95 of gestation and morphometric studies were completed on tibial radiographs and tibial growth cartilage metaphyseal junctions. Mean tibial areas were significantly reduced (P < 0.01) in fetuses from infected ewes at 35 and 42 days after infection and growth cartilage metaphyseal junctions were less mature in fetuses from infected ewes at 42 days after infection. Positive immunostaining for BDV antigen was demonstrated in the brains of all fetuses from infected ewes between 14 and 42 days after infection. Attempts to demonstrate BDV antigen in bone proved unsuccessful. It is concluded that intrauterine growth retardation is an early manifestation of BDV infection in lambs and that the process is initiated shortly following infection of the fetus.
Assuntos
Doença da Fronteira/fisiopatologia , Vírus da Doença da Fronteira/fisiologia , Retardo do Crescimento Fetal/veterinária , Complicações Infecciosas na Gravidez/veterinária , Doenças dos Ovinos/fisiopatologia , Animais , Anticorpos Monoclonais/análise , Anticorpos Monoclonais/imunologia , Anticorpos Antivirais/análise , Anticorpos Antivirais/imunologia , Antígenos Virais/análise , Antígenos Virais/imunologia , Doença da Fronteira/imunologia , Doença da Fronteira/virologia , Vírus da Doença da Fronteira/imunologia , Vírus da Doença da Fronteira/isolamento & purificação , Desenvolvimento Embrionário e Fetal/fisiologia , Feminino , Retardo do Crescimento Fetal/fisiopatologia , Retardo do Crescimento Fetal/virologia , Idade Gestacional , Lâmina de Crescimento/citologia , Lâmina de Crescimento/embriologia , Lâmina de Crescimento/crescimento & desenvolvimento , Imuno-Histoquímica , Gravidez , Complicações Infecciosas na Gravidez/fisiopatologia , Complicações Infecciosas na Gravidez/virologia , Radiografia , Ovinos , Doenças dos Ovinos/virologia , Tíbia/diagnóstico por imagem , Tíbia/embriologia , Tíbia/crescimento & desenvolvimentoRESUMO
Risk for human T-cell lymphotropic virus type (HTLV-I) and human immunodeficiency virus (HIV) infection was evaluated in 100 homosexual or bisexual men from Trinidad. High seropositivity for HTLV-I (15% vs 2.4% in the general population) was linked to duration of homosexuality and numbers of partners, suggesting that HTLV-I, like HIV, can be transmitted by homosexual sex. Forty percent of homosexuals compared with 0.19% of the general population were seropositive for HIV, and sexual contact with US homosexual men and prior history of gonorrhea were major risk factors. The seroprevalence of HIV was three times higher than that for HTLV-I, suggesting that HIV is more efficiently transmitted, especially since HIV appears to have been recently introduced into Trinidad. Altered immune status was prominent in individuals infected with HIV and coinfected with HIV and HTLV-I. Whether HIV/HTLV-I coinfection amplifies clinical effects is a hypothesis that will require further evaluation.
Assuntos
Síndrome da Imunodeficiência Adquirida/transmissão , Infecções por Deltaretrovirus/transmissão , Homossexualidade , Síndrome da Imunodeficiência Adquirida/epidemiologia , Adolescente , Adulto , Infecções por Deltaretrovirus/epidemiologia , Humanos , Masculino , Risco , Testes Sorológicos , Linfócitos T/classificação , Trinidad e TobagoAssuntos
Legislação Médica , Assistência Pública , Vacinação/efeitos adversos , Humanos , Controle de Qualidade , Risco , Reino UnidoRESUMO
Risk for human T-cell lymphotropic virus type (HTLV-I) and human immunodeficiency virus (HIV) infection was evaluated in 100 homosexual or bisexual men from Trinidad. High seropositivity for HTLV-I (15 percent vs 2.4 percent in the general population) was linked to duration of homosexuality and numbers of partners, suggesting that HTLV-I, like HIV, can be transmitted by homosexual sex. Forty percent of homosexuals compared with 0.19 percent of the general population were seropositive for HIV, and sexual contact with US homosexual men and prior history of gonorrhea were major risk factors. The seroprevalence of HIV was three times higher than for HTLV-I, suggesting that HIV is more efficiently transmitted, especially since HIV appears to have been recently introduced into Trinidad. Altered immune status was prominent in individuals infected with HIV and coinfected with HIV and HTLV-I. Whether HIV/HTLV-I coinfection amplifies clinical effects is a hypothesis that will require further evaluation.(AU)