Outbreak of human metapneumovirus infection in psychiatric inpatients: implications for directly observed use of alcohol hand rub in prevention of nosocomial outbreaks.

Nosocomial outbreaks of infectious diseases in psychiatric facilities are not uncommon but the implementation of infection control measures is often difficult. Here, we report an outbreak of an acute respiratory illness in a psychiatric ward between 29 July and 20 August 2005 involving 31 patients. Human metapneumovirus was detected in seven (23%) patients by reverse transcription-polymerase chain reaction and nucleotide sequencing. A review of outbreak surveillance records showed that six nosocomial outbreaks occurred in the year 2005, of which four (67%) were confirmed or presumably related to a respiratory viral infection. Directly observed deliveries of alcohol hand rub 4-hourly during daytime to all psychiatric patients was instituted in December 2005. Only one nosocomial respiratory viral outbreak occurred in the following year. The total number of patients and staff involved in nosocomial outbreaks due to presumed or proven respiratory virus infections decreased significantly from 60 to six (P<0.001), whereas those due to all types of nosocomial outbreaks also decreased from 70 to 24 (P=0.004). Alcohol hand rub has been shown to have potent bactericidal and virucidal activity against a wide range of nosocomial pathogens. Regular use of directly observed alcohol hand rub may decrease the incidence and scale of nosocomial outbreaks due to enveloped respiratory viruses especially in mentally incapacitated patients.

A medium-term follow-up study of a cohort of Chinese patients after first hospitalisation in a gazetted hospital for mania.

OBJECTIVES: To study the characteristics of a cohort of first-episode manic patients treated in a regional psychiatric unit in Hong Kong, to explore the predictors of re-admission, and to investigate their functional outcomes 4 years after first hospitalisation. METHODS: This was a medium-term follow-up study, using retrospective review of hospital records and clinical interviews at follow-up. Forty-four Chinese patients diagnosed as having their first-episode mania were discharged from a gazetted psychiatric ward in Hong Kong between January 1999 and June 2002. Their clinical characteristics on admission and prescribed medications on discharge were investigated. Their re-admission status was charted. The patients were contacted for follow-up assessment of their functional outcome at 4 years after their first hospitalisation. RESULTS: In our cohort of 44 patients, their first-episode mania mostly presented in young adulthood, as significantly disturbed behaviour deemed to require compulsory admission. Nineteen (43%) of the patients were re-admitted at least once within 4 years of being discharged, 6 of whom were re-admitted more than once. Compulsory admission at the first-episode mania predicted future re-admission. Alcohol and substance abuse were associated with earlier re-admission after the first-episode mania. None of the patients died. For those who were reassessed (28 patients), most lived with family members. In all, 21 patients were able to sustain open employment at 4 years after discharge. About half (n = 14) of the traceable patients were able to continue in full-time employment at 4 years, while 7 were doing part-time work. The median Global Assessment of Functioning score of the traceable group was 88. CONCLUSION: The results of this local study on patients with their first-episode of hospitalisation for mania were comparable to findings reported in western studies.