Coherence gate manipulation for enhanced imaging through scattering media by non-ballistic light in partially coherent interferometric systems.

Coherence gating is typically exploited for imaging through disordered media by least-scattered (ballistic) light. Ballistic light-based approaches produce clear images only when the proportion of ballistic to multiply scattered (non-ballistic) light is relatively high. To overcome this limitation, we counterintuitively utilize the coherence gate to image by the non-ballistic light, enabling us to retrieve information missing in the ballistic image. We show that non-ballistic images acquired by transversal coherence gate shifting have image quality and spatial resolution comparable to the ballistic image. Combining images for different coherence gate positions, we synthesize an image of quality superior to ballistic light approaches. We experimentally demonstrate our concept on quantitative phase imaging through biological tissue.

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging.

Solid tumor metastases cause most cancer-related deaths. The prevention of their occurrence misses suitable anti-metastases medicines newly labeled as migrastatics. The first indication of migrastatics potential is based on an inhibition of in vitro enhanced migration of tumor cell lines. Therefore, we decided to develop a rapid test for qualifying the expected migrastatic potential of some drugs for repurposing. The chosen Q-PHASE holographic microscope provides reliable multifield time-lapse recording and simultaneous analysis of the cell morphology, migration, and growth. The results of the pilot assessment of the migrastatic potential exerted by the chosen medicines on selected cell lines are presented.