Detalhe da pesquisa
1.
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg Med Chem Lett
; 23(12): 3592-8, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642482
2.
Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.
Bioorg Med Chem Lett
; 20(11): 3265-71, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20452767
3.
Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.
Bioorg Med Chem Lett
; 20(8): 2516-9, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20299215
4.
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity.
Bioorg Med Chem Lett
; 18(4): 1312-7, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18226897
5.
A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.
J Med Chem
; 47(16): 3962-71, 2004 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-15267235
6.
Update on the therapeutic potential of PDE4 inhibitors.
Expert Opin Investig Drugs
; 11(1): 1-13, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11772317
7.
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
J Med Chem
; 55(12): 5901-21, 2012 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22591402
8.
Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.
J Med Chem
; 52(23): 7706-23, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19954248
9.
Novel 5,6-dihydropyrazolo[3,4-E][1,4]diazepin-4 (1H)-one derivatives for the treatment of asthma and chronic obstructive pulmonary disease.
Expert Opin Ther Pat
; 17(9): 1183-9, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20618064
10.
Quinazoline and benzimidazole MCH-1R antagonists.
Bioorg Med Chem Lett
; 17(5): 1403-7, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17178222
11.
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators.
Bioorg Med Chem Lett
; 17(17): 4901-5, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17587578
12.
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Bioorg Med Chem Lett
; 17(2): 370-5, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17095213
13.
2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists.
Bioorg Med Chem Lett
; 17(20): 5704-8, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17822897
14.
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Bioorg Med Chem Lett
; 17(2): 363-9, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17107790
15.
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.
Bioorg Med Chem Lett
; 15(23): 5335-9, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16202581
16.
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Bioorg Med Chem Lett
; 15(3): 751-4, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664851
17.
Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists.
Bioorg Med Chem Lett
; 14(15): 4099-102, 2004 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15225734
18.
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Bioorg Med Chem Lett
; 12(12): 1613-5, 2002 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12039574
19.
8-Methoxyquinolines as PDE4 inhibitors.
Bioorg Med Chem Lett
; 12(12): 1617-9, 2002 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12039575
20.
7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Bioorg Med Chem Lett
; 12(3): 509-12, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11814830