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1.
Am J Otolaryngol ; 45(2): 104170, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38101127

RESUMO

BACKGROUND: Intratympanic steroids (ITS) in treating sudden sensorineural hearing loss (SSNHL) have become more widespread. AIM: This study investigates whether ITS treatment provides additional benefits when combined with systemic steroids (SS) in patients with severe and profound SSNHL. MATERIALS AND METHODS: Patients diagnosed with severe and profound SSNHL were divided into two groups: SS group and SS combined with ITS group. Pure-tone audiometry was performed before and three months after treatment completion. The pure-tone average (PTA), frequency-specific hearing gains, and average values were compared between the groups. RESULTS: The study included 57 patients (27 SS, 30 ITS), with a mean age of 50.09 ± 15.56. Before treatment: SS PTA 84.40 ± 15 dB HL, ITS 87.50 ± 9.38 dB HL (p = 0.36). After treatment: SS 62.2 ± 23.13 dB HL, ITS 65.17 ± 12.19 dB HL (p = 0.55). Average hearing gain: SS 22.19 ± 13.81 dB HL, ITS 22.33 ± 12.24 dB HL (p = 0.96). Frequency-specific gains were similar (p > 0.05). SS group: 12 slight improvement, 10 no improvement, 3 partial, 2 complete recovery. ITS group: 23 slight improvement, 6 no improvement, 1 partial. CONCLUSION: In our study, combining ITS with SS treatment did not provide additional benefits in treating severe and profound SSNHL.


Assuntos
Perda Auditiva Neurossensorial , Perda Auditiva Súbita , Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Glucocorticoides/uso terapêutico , Dexametasona/uso terapêutico , Resultado do Tratamento , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/tratamento farmacológico , Perda Auditiva Súbita/diagnóstico , Perda Auditiva Súbita/tratamento farmacológico , Audiometria de Tons Puros , Injeção Intratimpânica , Estudos Retrospectivos
2.
J Craniofac Surg ; 33(5): e447-e449, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34690315

RESUMO

ABSTRACT: We aimed to evaluate whether the nasal septum deviation affects the development of sinonasal structures. Patients who had undergone paranasal sinus computed tomography (PNS-CT) imaging due to nasal obstruction were divided into 3 groups according to the septal deviation angle; group I: 0° to 9°, group II: 10° to 15°, and group III: >15°. The features of sinonasal structures were recorded when evaluating PNS-CT. There were totally 234 patients, 119 patients in group I, 68 in group II, and 47 in group III. On the opposite side of the deviation, keros 3 was significantly more in group III ( P < 0.001). Although the incidence of concha bullosa and agger nasi cell were not affected by the degree of deviation ( P > 0.05), the incidence of Haller and Onodi cells were significantly higher in group III ( P < 0.001). In addition, all cells were observed more in the opposite side of the deviation in each group ( P < 0.001). Maxillary sinus retention cysts and hypoplasia of maxillary and frontal sinuses, as an indicator of the low pneumatization of the sinuses, are seen more on the same side of nasal septum deviation, increasing with the degree of deviation increases ( P < 0.001). Nasal septum deviation affects the development of sinonasal structures by affecting the pneumatization. Preoperative PNS-CT evaluation is important in order to be aware of the situations that we may encounter during surgery and to provide adequate treatment.


Assuntos
Seio Frontal , Doenças Nasais , Humanos , Seio Maxilar , Septo Nasal/anormalidades , Septo Nasal/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos
3.
Eur Arch Otorhinolaryngol ; 275(10): 2541-2548, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30105404

RESUMO

PURPOSE: To evaluate the course of lower cranial nerves (CNs) within the neck in relation to surrounding structures and anatomic landmarks via a cadaveric dissection study. METHODS: A total of 70 neck dissections (31 bilateral, 8 unilateral) were performed on 39 adult fresh cadavers [mean (SD) age: 38.5 (11.2) years, 29 male, 10 female] to identify the course of lower CNs [spinal accessory nerve (SAN), vagus nerve and hypoglossal nerve] within the neck in relation to surrounding structures [internal jugular vein (IJV), common carotid artery (CCA)] and distance to anatomical landmarks (cricoid cartilage, hyoid bone, digastric muscle). RESULTS: SAN travelled most commonly anterior to IJV (51.4%) at the level of jugular foramen, while travelling lateral to IJV at the post belly of digastric (55.7%) and inferior to digastric muscle (90%) in most neck dissections. Vagus nerve travelled lateral to CCA in majority (94.3%) of dissections, while medial (2.9%), posterolateral (1.4%) and posterior (1.4%) positions were also noted. Average distance of hypoglossal nerve was 27.7 (9.7) mm to carotid bifurcation, 9.3 (3.9) mm to hyoid bone, and 54.7 (18.0) mm to the inferior border of cricoid cartilage. CONCLUSION: In conclusion, our findings indicate that anatomic variations are not rare in the course of lower CNs within the neck in relation to adjacent structures, and awareness of these variations together with knowledge of distance to certain anatomic landmarks may help the surgeon to identify lower CNs during neck surgery and prevent potential nerve injuries.


Assuntos
Pontos de Referência Anatômicos/anatomia & histologia , Nervos Cranianos/anatomia & histologia , Esvaziamento Cervical/métodos , Músculos do Pescoço/inervação , Pescoço/inervação , Nervo Acessório , Adulto , Cadáver , Feminino , Humanos , Nervo Hipoglosso/anatomia & histologia , Masculino , Nervo Vago/anatomia & histologia
4.
J Craniofac Surg ; 29(7): 1960-1962, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30157139

RESUMO

Objective of this study is to determine the etiology of patients applied with revision endoscopic dacryocystorhinostomy (DCR) and to evaluate the operation results.The patients were retrospectively evaluated in respect of demographic data, the time from primary to revision surgery, revision etiology, the use of bicanalicular silicone nasolacrimal tube (BNLT), the time to postoperative removal of the silicone tube, and the success of the revision surgery.The study included 27 patients applied with revision endoscopic DCR between January 2013 and January 2016. The mean age of the patients was 46.7 ±â€Š11.7 years. The mean time from the first operation to revision surgery was 7.2 ±â€Š6.1 months (range, 1-24 months). During the endoscopic DCR, synechia was observed in 2 (7.4%), granulation tissue in 7 (25.9%), inadequate bone window in 5 (18.52%), and membranous scar around the ostium in 22 (81.4%) patients. More than 1 etiologic problem was determined in 8 patients. During the revision procedure, BNLT was applied to 12 (44.4%) patients. At the final follow-up examination, the complaint of epiphora had completely recovered in 18 (66.6%) patients and there were in 9 (33.3%) patients. The mean time to removal of the BNLT was 1.7 ±â€Š0.57 months (range, 1-3 months).The most common cause of recurrent epiphora in endoscopic DCR was the formation of membranous scar. The use of the mucosal flap technique in primary surgery and the application of BNLT to all patients in revision surgery may increase the functional success rate.


Assuntos
Dacriocistorinostomia/efeitos adversos , Dacriocistorinostomia/métodos , Endoscopia/métodos , Doenças do Aparelho Lacrimal/cirurgia , Idoso , Cicatriz/cirurgia , Dacriocistorinostomia/instrumentação , Endoscopia/instrumentação , Feminino , Tecido de Granulação/cirurgia , Humanos , Intubação , Masculino , Pessoa de Meia-Idade , Ducto Nasolacrimal , Complicações Pós-Operatórias/cirurgia , Reoperação/métodos , Estudos Retrospectivos , Silicones , Retalhos Cirúrgicos
5.
Int Tinnitus J ; 19(1): 57-62, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-27186834

RESUMO

OBJECTIVE: Nonorganic hearing loss (NOHL) is a lack of consistency in audiological testing. Although NOHL is relatively rare, it is important to identify suspicious patients. This study was designed to evaluate the effectiveness of Stenger test and acoustic reflexes test (ART) in the evaluation of patients with suspicious of unilateral NOHL. STUDY DESIGN: A prospective study Methods: In this study, 474 adult patients with suspicious unilateral profound or total hearing loss were included. Pure tone audiometry (PTA), speech audiometry, Stenger test, ART and click-evoked auditory brainstem response (ABR) measurements were performed. The sensitivity, specificity and predictive values of the Stenger test and ART for unilateral, profound to total NOHL were assessed by comparing these with the results of ABR. RESULTS: The sensitivity and specificity of the Stenger test in verifying unilateral, profound hearing loss were 99% and 57%, respectively. The positive and negative predictive values of the test were 88% and 97%, respectively. The sensitivity and specificity of the ART in verifying unilateral, profound hearing loss were 96% and 60% at 1000 Hz and 98% and 60% at 2000 Hz, respectively. The positive and negative predictive values of the ART were 50% and 97% at 1000 Hz, and 75% and 97% at 2000 Hz, respectively. CONCLUSION: The Stenger test and ART are widely used for the evaluation of unilateral or asymmetrical NOHL. In our opinion, these tests are significantly powerful. More difficult cases require ABR to verify nonorganic hearing loss and to exclude specific diagnoses that may imitate NOHL.

6.
Eur Arch Otorhinolaryngol ; 270(2): 609-13, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22777215

RESUMO

Septorhinoplasty aims to improve not only the esthetic appearance but also breathing function of the nose. Although the esthetic improvement can be judged by the patient and the surgeon easily, evaluation of nasal breathing is more complicated. Besides the subjective symptom scores given by the patient, some objective methods have been developed. One of the most widely used of these objective methods is acoustic rhinometry, which gives valuable information about the cross-sectional areas and volumes of the nasal airway as a function of distance from the nostril. Since the introduction of acoustic rhinometry, many papers were reported regarding its efficiency with some conflicting conclusions. Septorhinoplasty has the potential to narrow the nasal airway, especially if it includes lateral osteotomies and hump reduction. We aimed to evaluate the role of rhinoplasty on nasal obstruction with the help of subjective symptom scores and acoustic rhinometry. The study consisted of 26 patients who underwent septorhinoplasty. Before and after surgery, the symptom scores and findings of acoustic rhinometry were collected both before and after decongestion of the nasal mucosa. Symptom scores decreased on both sides, which were statistically significant (p < 0.05), however, the changes in cross-sectional areas of the nasal airway were not statistically significant (p > 0.05). The correlation between the symptom scores and acoustic rhinometry findings was not significant for all levels. The effect of septorhinoplasty on nasal airway and some important maneuvers to protect against nasal obstruction are discussed.


Assuntos
Obstrução Nasal/diagnóstico , Septo Nasal/cirurgia , Rinometria Acústica , Rinoplastia , Adulto , Feminino , Humanos , Masculino , Período Pós-Operatório , Adulto Jovem
7.
PLoS One ; 18(5): e0284647, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37195911

RESUMO

BACKGROUND: The aim of this paper was to evaluate the change in 25-hidroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic. METHODS: In this retrospective, cross-sectional and methodological study included 86,772 patients (18-75 years) samples who were admitted to the Izmir Dokuz Eylul University Hospital (latitude and longitude (Turkey): 27 E 09; 38 N 25, respectively) for various reasons and whose 25(OH)D levels were measured in the biochemistry unit between 2019-2020 and 2020-2021 (before and during the COVID-19 outbreak). A time series analysis of monthly averages for 25(OH)D was performed. For the purpose of seasonal study, the mean levels of 25(OH)D are grouped by years. Data were modeled in terms of 25(OH)D levels using the MATLAB Curve Fitting Toolbox. RESULTS: There was no significant difference between the sexes according to 25(OH)D levels (p>0.05). 25(OH)D levels were significantly higher in the summer months and lower in the winter months (p<0.001). When comparing the spring months, 25(OH)D levels in 2020 (18 ± 10) were found to be significantly lower than in 2019 (22 ± 12) (p<0.001); on the contrary, when examined based on the summer, autumn, and winter months, it was determined that 25(OH)D levels increased in 2020 (summer: 25 ± 13, autumn: 25 ± 14, and winter: 19 ± 10) compared to 2019 (summer: 23 ± 11, autumn: 22 ± 10, and winter: 19 ± 11) (p<0.001). In the estimates curve obtained with an error margin of 11% in the time series analysis, it was estimated that the 25(OH)D averages after the pandemic would be similar to those before the pandemic. CONCLUSIONS: Restrictions, partial or complete closures, and curfews can significantly affect individuals' 25(OH)D levels during the COVID-19 outbreak. There is a need for multicenter studies with larger populations covering different regions to strengthen and support our results.


Assuntos
COVID-19 , Deficiência de Vitamina D , Humanos , Estudos Transversais , Pandemias , Estudos Retrospectivos , COVID-19/epidemiologia , Vitamina D , Calcifediol , Deficiência de Vitamina D/epidemiologia , Estações do Ano
8.
Eur Arch Otorhinolaryngol ; 269(7): 1777-81, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22160143

RESUMO

The aim of this study was to investigate the effects of four different types of nasal packs on pain, nasal fullness and postoperative bleeding following septoplasty. Prospective randomised double blind study was conducted. The study group included 119 patients who underwent endonasal septoplasty under general anaesthesia. Four types of nasal packing materials were utilized: (1) Merocel standard 8-cm nasal dressing without airway, (2) Doyle Combo splint (DCS), (3) Merocel in a glove finger and (4) Vaseline gauze. All packs were removed at the 48th hour (±3 h) after the surgery. Three different variables were investigated following the surgical procedure: (1) pain, (2) nasal fullness and (3) bleeding after removal of the nasal packing material. DCS produced the greatest pain at the first and sixth postoperative hours. At the first postoperative day, the greatest pain score was reported for Merocel in the glove finger and the least for Merocel. The pain scores during the removal of the nasal packings were highest for Merocel and lowest for Merocel in the glove finger. DCS had the lowest nasal fullness score. Bleeding ratio was highest for Merocel, followed by Vaseline gauze, DCS and Merocel in the glove finger. Many different commercially available packing materials are presently used, each with inherent advantages and disadvantages. We evaluated the pain, nasal fullness and bleeding potential of four nasal packing materials and determined that Merocel had the highest pain potential during removal and the highest rate of bleeding following removal.


Assuntos
Septo Nasal/cirurgia , Procedimentos Cirúrgicos Nasais , Hemorragia Pós-Operatória/prevenção & controle , Tampões Cirúrgicos/efeitos adversos , Adulto , Método Duplo-Cego , Epistaxe/etiologia , Epistaxe/prevenção & controle , Feminino , Humanos , Complicações Intraoperatórias/terapia , Masculino , Teste de Materiais/métodos , Obstrução Nasal/etiologia , Obstrução Nasal/prevenção & controle , Procedimentos Cirúrgicos Nasais/efeitos adversos , Procedimentos Cirúrgicos Nasais/instrumentação , Procedimentos Cirúrgicos Nasais/métodos , Medição da Dor , Dor Pós-Operatória/prevenção & controle , Aderências Teciduais/prevenção & controle , Resultado do Tratamento
9.
J Int Adv Otol ; 18(6): 478-481, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36349668

RESUMO

BACKGROUND: It is aimed to investigate the incidence of cerebrospinal fluid gusher in cochlear implantation and the association between cerebrospinal fluid gusher and inner-ear malformations in adult and pediatric patients. METHODS: A retrospective case review of 1025 primary cochlear implantation procedures was performed. Patients with inner-ear malformation or cerebrospinal fluid gusher during primary cochlear implantation were included and divided into 2 groups according to age: pediatric and adult groups. RESULTS: The incidence of inner-ear malformation was 4.19% (17/405) and 7.6% (47/620) in the adult and pediatric groups, respectively. There was a significant difference in the incidence of inner-ear malformation in the pediatric group. The incidence of cerebrospinal fluid gusher was 0.9% (4/405) and 4.1% (26/620) in the adult and pediatric groups, respectively. There was a significant difference in the incidence of gusher between the adult and pediatric groups. CONCLUSION: The incidence of a cerebrospinal fluid gusher is higher in the pediatric group, compared to adults due to a higher rate of inner-ear malformation. Inner-ear malformation poses a risk factor for cerebrospinal fluid gusher.


Assuntos
Implante Coclear , Implantes Cocleares , Orelha Interna , Adulto , Humanos , Criança , Implante Coclear/métodos , Estudos Retrospectivos , Orelha Interna/cirurgia , Orelha Interna/anormalidades , Implantes Cocleares/efeitos adversos , Otorreia de Líquido Cefalorraquidiano/epidemiologia , Otorreia de Líquido Cefalorraquidiano/etiologia
10.
Eur Arch Otorhinolaryngol ; 268(12): 1735-41, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21431435

RESUMO

Idiopathic sudden sensorineural hearing loss is a rare disorder of unknown pathogenesis in which hearing is lost partially or totally. About 60 treatment modalities have been described. We aimed to compare the efficacy of hyperbaric oxygen, oral steroid, intratympanic steroid therapy and their combinations in idiopathic sudden sensorineural hearing loss patients. Files of patients who were followed up between 2004 and 2010 in our clinic were examined retrospectively. Patients were divided into four groups according to the therapy received: Oral steroid, oral steroid + hyperbaric oxygen, intratympanic steroid and hyperbaric oxygen. Treatment success was assessed by Siegel criteria and mean gains using pre-treatment and post-treatment audiograms. 217 patients and 219 ears were examined. The proportion of patients responding to therapy was the highest in the oral steroid + hyperbaric oxygen group with 86.88% (53/61) followed by the oral steroid group with 63.79% (37/58), the intratympanic steroid group with 46,51% (20/43) and the hyperbaric oxygen group with 43.85% (25/57). The proportion of patients who had complete recovery was the highest in the oral steroid + hyperbaric oxygen group with 42.6% (26/61) followed by the oral steroid group with 19.0% (11/58), the hyperbaric oxygen group with 17.5% (10/57) and the intratympanic steroid group with 11.6% (5/43). The oral steroid + hyperbaric oxygen group has the highest mean hearing gain among all groups (p < 0.05). Idiopathic sudden sensorineural hearing loss patients receiving oral steroid + hyperbaric oxygen combination therapy have a higher likelihood of recovery than patients receiving oral steroids, hyperbaric oxygen or intratympanic steroids alone.


Assuntos
Glucocorticoides/administração & dosagem , Perda Auditiva Neurossensorial/terapia , Perda Auditiva Súbita/terapia , Audição , Oxigenoterapia Hiperbárica/métodos , Recuperação de Função Fisiológica/fisiologia , Administração Oral , Administração Tópica , Audiometria , Seguimentos , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Súbita/diagnóstico , Perda Auditiva Súbita/fisiopatologia , Humanos , Estudos Retrospectivos , Resultado do Tratamento , Membrana Timpânica
11.
J Craniofac Surg ; 22(3): 1118-9, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21586962

RESUMO

Benign tumors of the nerve sheath are of 2 types: schwannoma and neurofibroma. Neurofibromas are most commonly found with neurofibromatosis type 1 and characterized by incorporation of the nerve fibers within their matrix. Both benign and malignant tumors can affect the facial nerve. These tumors can be intrinsic or extrinsic; in other words, it can originate from the facial nerve itself or from a contiguous structure or a metastatic disease. Actually, extrinsic tumors are far more common than intrinsic tumors. Intraparotid location of benign tumors of the facial nerve sheath is considered a rare event compared with intratemporal location.


Assuntos
Nervo Facial/patologia , Neoplasias de Bainha Neural/patologia , Neoplasias de Bainha Neural/cirurgia , Neurofibroma/patologia , Neurofibroma/cirurgia , Neurofibromatose 1/patologia , Biópsia , Criança , Humanos , Imageamento por Ressonância Magnética , Masculino
12.
Dysphagia ; 25(3): 258-60, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19784701

RESUMO

The case of a 29-year-old patient with active laryngeal tuberculosis predominantly involving the epiglottis, without pulmonary disease, is presented. The predominant symptoms are dysphagia, odynophagia, and hoarseness. Laryngeal carcinoma, which shares almost the same symptoms and signs, should be ruled out immediately. Laryngeal tuberculosis is discussed with a brief literature review.


Assuntos
Antituberculosos/uso terapêutico , Epiglote/microbiologia , Tuberculose Laríngea/diagnóstico , Adulto , Humanos , Masculino , Mycobacterium tuberculosis , Tuberculose Laríngea/tratamento farmacológico , Tuberculose Laríngea/microbiologia
13.
Eur Arch Otorhinolaryngol ; 267(6): 917-23, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19908054

RESUMO

The objective of the prospective study is to examine the laryngeal changes by laryngeal videostroboscopy and electromyography (EMG) regarding new-onset dysphonia in asthmatic patients taking inhaled corticosteroids (ICS). Laryngeal changes and electrophysiological status of the laryngeal muscles were evaluated by these methods in 12 patients both at the time of presentation of dysphonia and after cessation of therapy. Laryngeal changes of our patients were mucosal edema, erythema, thickening, adduction deficit, nodule and irregularity in videostroboscopy. Significant correlations were found between laryngeal pathology and dosage and duration of ICS therapy. We detected myopathy by EMG in most of the patients. Also, EMG revealed that cricothyroid muscle was much more affected than thyroarytenoid muscle. In conclusion, we consider that steroid myopathy or mucosal inflammatory theory alone is not sufficient to explain the etiopathogenesis of dysphonia in asthmatic patients taking ICS. The laryngeal mucosal changes were detected by laryngeal videostroboscopic examination in some asthmatic patients, with dysphonia using ICS, and/or laryngeal myopathy was found by laryngeal EMG in some of them in this study. Thus, various factors may have role simultaneously in the occurrence of dysphonia.


Assuntos
Corticosteroides/toxicidade , Asma/tratamento farmacológico , Disfonia/induzido quimicamente , Laringe/efeitos dos fármacos , Administração por Inalação , Corticosteroides/administração & dosagem , Adulto , Idoso , Disfonia/diagnóstico , Eletromiografia/efeitos dos fármacos , Feminino , Humanos , Mucosa Laríngea/efeitos dos fármacos , Músculos Laríngeos/efeitos dos fármacos , Laringoscopia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estroboscopia , Gravação em Vídeo , Prega Vocal/efeitos dos fármacos
14.
J Craniofac Surg ; 21(1): 261-2, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20098193

RESUMO

Hypoglossal schwannoma is a rarely encountered skull base lesion that has generally both intracranial and extracranial parts. This article reports a case of hypoglossal schwannoma that is purely extracranial and presents itself only with persistent headache. Magnetic resonance imaging delineated a mass at the skull base that consisted of both cystic and solid components, consistent with a nerve sheath tumor. Cervical approach was chosen, and the mass was completely removed. Postoperatively, the patient developed hypoglossal nerve palsy because the hypoglossal nerve was sacrificed. Hypoglossal schwannomas are briefly discussed with a literature review.


Assuntos
Neoplasias dos Nervos Cranianos/complicações , Cefaleia/etiologia , Doenças do Nervo Hipoglosso/complicações , Neurilemoma/complicações , Adulto , Neoplasias dos Nervos Cranianos/diagnóstico , Neoplasias dos Nervos Cranianos/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Doenças do Nervo Hipoglosso/diagnóstico , Doenças do Nervo Hipoglosso/cirurgia , Imageamento por Ressonância Magnética , Neurilemoma/diagnóstico , Neurilemoma/cirurgia
15.
Otol Neurotol ; 41(10): e1185-e1192, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32976341

RESUMO

HYPOTHESIS: The ototoxic effects of aminoglycosides are well known. Gentamicin carries a substantial risk of hearing loss. Gentamicin is widely used to combat life-threatening infections, despite its ototoxic effects. Calcium dobesilate is a pharmacologically active agent used to treat many disorders due to its vasoprotective and antioxidant effects. We investigated the therapeutic role of calcium dobesilate against gentamicin-induced cochlear nerve ototoxicity in an animal model. METHODS: Thirty-two Sprague Dawley rats were divided into four groups: Gentamicin, Gentamicin + Calcium Dobesilate, Calcium Dobesilate, and Control. Preoperative and postoperative hearing thresholds were determined using auditory brainstem response thresholds with click and 16-kHz tone-burst stimuli. Histological analysis of the tympanic bulla specimens was performed under light and transmission electron microscopy. The histological findings were subjected to semiquantitative grading, of which the results were compared between the groups. RESULTS: Gentamicin + Calcium Dobesilate group had, on average, 27 dB better click-evoked hearing than Gentamicin group (p < 0.01), whereas the difference was not significant with 16-kHz tone-burst stimuli (p > 0.01). Histologically examining the Control and Calcium Dobesilate groups revealed normal ultrastructural appearances. The Gentamicin group showed the most severe histological alterations including myelin destruction, total axonal degeneration, and edema. The histological evidence of damage was significantly reduced in the Gentamicin + Calcium Dobesilate group compared with the Gentamicin group. CONCLUSION: Adding oral calcium dobesilate to systemic gentamicin was demonstrated to exert beneficial effects on click-evoked hearing thresholds, as supported by the histological findings.


Assuntos
Dobesilato de Cálcio , Ototoxicidade , Animais , Nervo Coclear , Potenciais Evocados Auditivos do Tronco Encefálico , Gentamicinas/toxicidade , Ratos , Ratos Sprague-Dawley
16.
J Craniofac Surg ; 20(6): 2095-6, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19881363

RESUMO

A case of a 43-year-old white woman who was admitted to our clinic with the complaints of chronic sinusitis and wound infection after Caldwell-Luc operation performed for chronic sinusitis is presented. Necrotic lesion then extended to the nasal cavity and skin of the face. The biopsy revealed natural killer/T-cell lymphoma. The patient was treated with chemotherapy; however, the patient died owing to sepsis. Sinonasal lymphoma is a rare disease. It is managed with chemotherapy and radiotherapy. The prognosis is poor. A high index of clinical suspicion is required for early diagnosis.


Assuntos
Linfoma Extranodal de Células T-NK/patologia , Neoplasias Nasais/patologia , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Diagnóstico Diferencial , Evolução Fatal , Feminino , Humanos , Linfoma Extranodal de Células T-NK/tratamento farmacológico , Sinusite Maxilar/diagnóstico , Sinusite Maxilar/cirurgia , Necrose , Neoplasias Nasais/tratamento farmacológico , Infecção dos Ferimentos/diagnóstico
17.
J Craniofac Surg ; 20(4): 1294-7, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19625854

RESUMO

BACKGROUND AND AIMS: Paragangliomas of the head and neck are highly vascular lesions originating from paraganglionic tissue located at the carotid bifurcation (carotid body tumors), along the vagus nerve (vagal paragangliomas), and in the jugular fossa and tympanic cavity (jugulotympanic paragangliomas) and should be considered in the evaluation of all lateral neck masses. The aim of this study is to review an institutional experience in the management of these tumors. MATERIALS AND METHODS: Twenty-six patients with 27 paragangliomas were treated in our institution during a period of 7 years (2000-2007). There were 15 women (57.6%) and 11 men (42.4%) with a mean age of 33.5 years. A painless lateral neck mass was the main finding in 16 patients (61.5%). There was no evidence of a functional tumor. Carotid angiography was performed on all of our patients (100%) to define the vascular anatomy of the lesion. Twenty-two paragangliomas (of the 25 operated paragangliomas; 88%) underwent selective embolization of the major feeding arteries. We performed surgery on 24 (92.3%) patients. Two patients were treated with radiotherapy. RESULTS: Most lesions were paragangliomas of the carotid bifurcation (n = 14 [51.8%]), whereas 6 patients were diagnosed with jugular (22.2%), 1 with a vagal (3.7%), 1 with a tympanic paraganglioma (3.7%), 2 with jugulotympanic paraganglioma (7.4%), and 1 with laryngeal paraganglioma (3.7%). In 1 patient (3.8%), bilateral paragangliomas in the carotid bifurcation were detected. There was an evidence of malignancy in all cases (3.8%). Preoperative embolization has proven successful in reducing tumor vascularity in approximately 22 (of 25 who accepted surgery; 88%) paraganglioma patients. The common preoperative complication was vascular injury, which occurred in 6 (23%) of 26 patients; the main postoperative complication was transient cranial nerve deficit in 4 (15.3%) of 26 patients; and a permanent Horner syndrome was documented in 2 patients (7.6%). Cerebrospinal fluid leak occurred in 1 patient (3.7%). Postoperatively, stroke was occurred in 1 patient (3.7%). Two patients with jugular paraganglioma were treated with irradiation because of skull base extension with significant symptomatic relief. CONCLUSIONS: The primary therapeutic option for paragangliomas is complete excision of tumor with preservation of vital neurovascular structures. Combined therapeutic approach with preoperative selective embolization followed by surgical resection is the safe and the effective method for complete excision of the tumors with a reduced morbidity rate.


Assuntos
Neoplasias de Cabeça e Pescoço/cirurgia , Paraganglioma Extrassuprarrenal/cirurgia , Adulto , Angiografia Digital , Diagnóstico Diferencial , Embolização Terapêutica , Feminino , Neoplasias de Cabeça e Pescoço/diagnóstico , Humanos , Imageamento por Ressonância Magnética , Masculino , Paraganglioma Extrassuprarrenal/diagnóstico , Resultado do Tratamento , Ultrassonografia Doppler
18.
J Voice ; 33(5): 759-766, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29496298

RESUMO

OBJECTIVE: The aim of this study was to investigate the effects of intracordal estradiol and dexamethasone injection on wound healing in vocal fold injuries. STUDY DESIGN: A prospective controlled animal study was carried out. SETTING: This study was conducted at a tertiary center. SUBJECTS-METHODS: Ten rabbits were randomly divided into two groups. As surgical procedure, cordotomy technique was performed in the middle third of the vocal folds bilaterally. In the first group, 0.1 mL of dexamethasone was injected into the right side, and 0.1 mL of saline was injected into the left side. In the second group, 0.1 mL of estradiol was injected into the right side, and 0.1 mL of saline was injected into the left side. Animals were sacrificed after 1 month and laryngeal specimens were evaluated histopathologically. RESULTS: No statistically significant difference was observed in terms of inflammatory response, epithelial thickness, type I and III collagen, and hyaluronic acid parameters in dexamethasone and estradiol injections compared to the saline injection. In terms of elastin level, estradiol injection demonstrated statistically higher values compared to the saline injection. Elastin level of dexamethasone injected vocal folds was not statistically different compared to the saline injection. No significant differences were observed in terms of inflammatory response, epithelial thickness, type I and III collagen, and hyaluronic acid parameters between the estradiol and dexamethasone injected vocal folds. CONCLUSION: It is thought that the effects of estradiol or dexamethasone injections may have similar effects on wound healing in vocal fold injuries. Intracordal estradiol injection has positive effects on tissue elastin levels.


Assuntos
Anti-Inflamatórios/administração & dosagem , Dexametasona/administração & dosagem , Estradiol/administração & dosagem , Prega Vocal/lesões , Cicatrização/efeitos dos fármacos , Animais , Avaliação Pré-Clínica de Medicamentos , Coelhos , Distribuição Aleatória
19.
Acta Otolaryngol ; 128(2): 181-5, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17851952

RESUMO

CONCLUSION: Odiosoft-Rhino (OR) is a non-invasive test that is completed in an extremely short period of time. It is easy to perform and little patient cooperation is needed. OR is safe and could be used in the rhinological setting if further improved. OBJECTIVE: To evaluate nasal obstruction objectively with a new technique, OR, and to compare the results with a widely accepted method, rhinomanometry, in normal subjects. SUBJECTS AND METHODS: OR and anterior RMM were performed in 79 subjects without any rhinologic symptoms and signs. Visual analogue scales (VAS) of nasal obstruction, nasal airway resistance and nasal expiratory and inspiratory sounds were analysed. RESULTS: VAS of nasal obstruction was found to be correlated with OR findings of expiration at 2000-4000 Hz frequency interval on both sides (r = 0.564, p < 0.01 for the left side, r = 0.533, p < 0.01 for the right side). Correlations were found (p < 0.05) between left 2000-4000 Hz in expiration OR and left expiration RMM, left 4000-6000 Hz in expiration OR and left expiration RMM, right 2000-4000 Hz in expiration OR and right expiration RMM, and right 4000-6000 Hz in expiration OR and right expiration RMM. No correlation was seen between VAS, anterior RMM and OR at inspiration in any interval.


Assuntos
Diagnóstico por Computador/instrumentação , Microcomputadores , Obstrução Nasal/diagnóstico , Ventilação Pulmonar/fisiologia , Rinomanometria , Processamento de Sinais Assistido por Computador/instrumentação , Software , Espectrografia do Som/instrumentação , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obstrução Nasal/fisiopatologia , Medição da Dor , Valores de Referência , Sensibilidade e Especificidade
20.
Acta Otolaryngol ; 138(1): 1-5, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28885129

RESUMO

OBJECTIVE: To identify the vertebral artery blood flow in different head positions in patients with positional vertigo with no specific diagnosis. METHODS: Patients with history of vestibular symptoms associated with changes in head position were enrolled into the study. Healthy volunteers were evaluated as control group. Doppler ultrasonography examination of the cervical segment of the vertebral arteries was performed under three different head positions: (i) supine position, (ii) head hyperextended and rotated to the right side and (iii) head hyperextended and rotated to the left side. RESULTS: In the study group, right and left vertebral artery blood flow was significantly lower in the ipsilateral hyperextended position compared to standard supine position (respectively p = .014; p = .001), but did not differ significantly when compared between the standard supine and contralateral hyperextended positions (respectively = .959; p = .669). In the control group, left and right vertebral artery blood flow did not differ significantly when the head was hyperextended to the right or left sides compared to standard supine position (p > .05). CONCLUSIONS: Our data demonstrated that the etiology of vestibular complaints in patients with undiagnosed positional vertigo might be related to impairment in vertebral artery blood flow according to head positions.


Assuntos
Cabeça/irrigação sanguínea , Postura/fisiologia , Artéria Vertebral/fisiologia , Vertigem/fisiopatologia , Adulto , Estudos de Casos e Controles , Feminino , Movimentos da Cabeça/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade
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