Detalhe da pesquisa
1.
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Bioorg Med Chem Lett
; 94: 129454, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37591316
2.
Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
J Biol Chem
; 291(30): 15778-87, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226591
3.
Selective Activation of AMPK ß1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J Pharmacol Exp Ther
; 361(2): 303-311, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289077
4.
Improving on nature: making a cyclic heptapeptide orally bioavailable.
Angew Chem Int Ed Engl
; 53(45): 12059-63, 2014 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25219505
5.
Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor.
Drug Metab Dispos
; 41(8): 1470-9, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23653442
6.
Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Nat Commun
; 14(1): 5158, 2023 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37620305
7.
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.
ACS Med Chem Lett
; 14(10): 1427-1433, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849537
8.
Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
J Org Chem
; 77(3): 1497-506, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22239115
9.
Synthesis of spiropiperidine lactam acetyl-CoA carboxylase inhibitors.
J Org Chem
; 77(22): 10050-7, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23127254
10.
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
J Med Chem
; 65(12): 8208-8226, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35647711
11.
Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs.
J Med Chem
; 63(20): 11831-11844, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32985885
12.
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
J Med Chem
; 63(19): 10879-10896, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32809824
13.
Total syntheses of (+/-)-platencin and (-)-platencin.
J Am Chem Soc
; 131(43): 15909-17, 2009 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19824676
14.
Total synthesis of platensimycin and related natural products.
J Am Chem Soc
; 131(46): 16905-18, 2009 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19874023
15.
Recent advances in the chemistry and biology of naturally occurring antibiotics.
Angew Chem Int Ed Engl
; 48(4): 660-719, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19130444
16.
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.
J Am Chem Soc
; 130(39): 13110-9, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18771264
17.
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(16): 7273-7288, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30036059
18.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466005
19.
Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.
Eur J Med Chem
; 127: 703-714, 2017 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27823886
20.
Cascade reactions in total synthesis.
Angew Chem Int Ed Engl
; 45(43): 7134-86, 2006 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17075967