Pesquisa | BVS IEC

1.

A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.

Broman, Michael T; Nadadur, Rangarajan D; Perez-Cervantes, Carlos; Burnicka-Turek, Ozanna; Lazarevic, Sonja; Gams, Anna; Laforest, Brigitte; Steimle, Jeffrey D; Iddir, Sabrina; Wang, Zhezhen; Smith, Linsin; Mazurek, Stefan R; Olivey, Harold E; Zhou, Pingzhu; Gadek, Margaret; Shen, Kaitlyn M; Khan, Zoheb; Theisen, Joshua W M; Yang, Xinan H; Ikegami, Kohta; Efimov, Igor R; Pu, William T; Weber, Christopher R; McNally, Elizabeth M; Svensson, Eric C; Moskowitz, Ivan P.

Circulation ; 149(15): 1205-1230, 2024 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-38189150

2.

Light can restore a heart's rhythm.

Efimov, Igor R.

Nature ; 626(8001): 961-962, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38383638

3.

Optical mapping and optogenetics in cardiac electrophysiology research and therapy: a state-of-the-art review.

Baines, Olivia; Sha, Rina; Kalla, Manish; Holmes, Andrew P; Efimov, Igor R; Pavlovic, Davor; O'Shea, Christopher.

Europace ; 26(2)2024 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-38227822

4.

RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease.

Schmeckpeper, Jeffrey; Kim, Kyungsoo; George, Sharon A; Blackwell, Daniel J; Brennan, Jaclyn A; Efimov, Igor R; Knollmann, Bjorn C.

J Mol Cell Cardiol ; 181: 67-78, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37285929

5.

Anthracycline cardiotoxicity is exacerbated by global p38ß genetic ablation in a sexually dimorphic manner but unaltered by cardiomyocyte-specific p38α loss.

George, Sharon A; Kiss, Alexi; Trampel, Katy Anne; Obaid, Sofian N; Tang, Lichao; Efimov, Igor R; Efimova, Tatiana.

Am J Physiol Heart Circ Physiol ; 325(5): H983-H997, 2023 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-37624097

6.

Ryanodine receptor inhibition with acute dantrolene treatment reduces arrhythmia susceptibility in human hearts.

George, Sharon A; Brennan-McLean, Jaclyn A; Trampel, Katy A; Rytkin, Eric; Faye, N Rokhaya; Knollmann, Bjorn C; Efimov, Igor R.

Am J Physiol Heart Circ Physiol ; 325(4): H720-H728, 2023 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-37566110

7.

A Sewing Approach to the Fabrication of Eco/bioresorbable Electronics.

Wu, Yunyun; Rytkin, Eric; Bimrose, Miles; Li, Shupeng; Choi, Yeon Sik; Lee, Geumbee; Wang, Yue; Tang, Lichao; Madrid, Micah; Wickerson, Grace; Chang, Jan-Kai; Gu, Jianyu; Zhang, Yamin; Liu, Jiaqi; Tawfick, Sameh; Huang, Yonggang; King, William P; Efimov, Igor R; Rogers, John A.

Small ; 19(49): e2305017, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37528504

8.

Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci.

Kyryachenko, Sergiy; Georges, Adrien; Yu, Mengyao; Barrandou, Takiy; Guo, Lilong; Bruneval, Patrick; Rubio, Tony; Gronwald, Judith; Baraki, Hassina; Kutschka, Ingo; Aras, Kedar K; Efimov, Igor R; Norris, Russel A; Voigt, Niels; Bouatia-Naji, Nabila.

Circ Res ; 128(5): e84-e101, 2021 03 05.

Artigo em Inglês | MEDLINE | ID: mdl-33508947

9.

Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas.

Hanna, Peter; Dacey, Michael J; Brennan, Jaclyn; Moss, Alison; Robbins, Shaina; Achanta, Sirisha; Biscola, Natalia P; Swid, Mohammed A; Rajendran, Pradeep S; Mori, Shumpei; Hadaya, Joseph E; Smith, Elizabeth H; Peirce, Stanley G; Chen, Jin; Havton, Leif A; Cheng, Zixi Jack; Vadigepalli, Rajanikanth; Schwaber, James; Lux, Robert L; Efimov, Igor; Tompkins, John D; Hoover, Donald B; Ardell, Jeffrey L; Shivkumar, Kalyanam.

Circ Res ; 128(9): 1279-1296, 2021 04 30.

Artigo em Inglês | MEDLINE | ID: mdl-33629877

10.

Systems genetics analysis defines importance of TMEM43/LUMA for cardiac- and metabolic-related pathways.

Gu, Qingqing; Xu, Fuyi; Orgil, Buyan-Ochir; Khuchua, Zaza; Munkhsaikhan, Undral; Johnson, Jason N; Alberson, Neely R; Pierre, Joseph F; Black, Dennis D; Dong, Deli; Brennan, Jaclyn A; Cathey, Brianna M; Efimov, Igor R; Towbin, Jeffrey A; Purevjav, Enkhsaikhan; Lu, Lu.

Physiol Genomics ; 54(1): 22-35, 2022 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-34766515

11.

Drawn-on-Skin Sensors from Fully Biocompatible Inks toward High-Quality Electrophysiology.

Patel, Shubham; Ershad, Faheem; Lee, Jimmy; Chacon-Alberty, Lourdes; Wang, Yifan; Morales-Garza, Marco A; Haces-Garcia, Arturo; Jang, Seonmin; Gonzalez, Lei; Contreras, Luis; Agarwal, Aman; Rao, Zhoulyu; Liu, Grace; Efimov, Igor R; Zhang, Yu Shrike; Zhao, Min; Isseroff, Roslyn Rivkah; Karim, Alamgir; Elgalad, Abdelmotagaly; Zhu, Weihang; Wu, Xiaoyang; Yu, Cunjiang.

Small ; 18(36): e2107099, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-36073141

12.

Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues.

Yang, Quansan; Wei, Tong; Yin, Rose T; Wu, Mingzheng; Xu, Yameng; Koo, Jahyun; Choi, Yeon Sik; Xie, Zhaoqian; Chen, Sheena W; Kandela, Irawati; Yao, Shenglian; Deng, Yujun; Avila, Raudel; Liu, Tzu-Li; Bai, Wubin; Yang, Yiyuan; Han, Mengdi; Zhang, Qihui; Haney, Chad R; Benjamin Lee, K; Aras, Kedar; Wang, Tong; Seo, Min-Ho; Luan, Haiwen; Lee, Seung Min; Brikha, Anlil; Ghoreishi-Haack, Nayereh; Tran, Lori; Stepien, Iwona; Aird, Fraser; Waters, Emily A; Yu, Xinge; Banks, Anthony; Trachiotis, Gregory D; Torkelson, John M; Huang, Yonggang; Kozorovitskiy, Yevgenia; Efimov, Igor R; Rogers, John A.

Nat Mater ; 20(11): 1559-1570, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34326506

13.

Transcriptional Patterning of the Ventricular Cardiac Conduction System.

Burnicka-Turek, Ozanna; Broman, Michael T; Steimle, Jeffrey D; Boukens, Bastiaan J; Petrenko, Nataliya B; Ikegami, Kohta; Nadadur, Rangarajan D; Qiao, Yun; Arnolds, David E; Yang, Xinan H; Patel, Vickas V; Nobrega, Marcelo A; Efimov, Igor R; Moskowitz, Ivan P.

Circ Res ; 127(3): e94-e106, 2020 07 17.

Artigo em Inglês | MEDLINE | ID: mdl-32290757

14.

ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.

Dai, Wenli; Nadadur, Rangarajan D; Brennan, Jaclyn A; Smith, Heather L; Shen, Kaitlyn M; Gadek, Margaret; Laforest, Brigitte; Wang, Mingyi; Gemel, Joanna; Li, Ye; Zhang, Jing; Ziman, Bruce D; Yan, Jiajie; Ai, Xun; Beyer, Eric C; Lakata, Edward G; Kasthuri, Narayanan; Efimov, Igor R; Broman, Michael T; Moskowitz, Ivan P; Shen, Le; Weber, Christopher R.

Circ Res ; 127(2): e28-e43, 2020 07 03.

Artigo em Inglês | MEDLINE | ID: mdl-32347164

15.

A ratiometric, fluorometric approach for surface charge mapping of biosilica features.

Parambath, Mithun; Fayyaz, Aneeqa; Efimov, Igor; Hanley, Quentin S; Perry, Carole C.

Analyst ; 147(23): 5586-5594, 2022 Nov 21.

Artigo em Inglês | MEDLINE | ID: mdl-36350014

16.

Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice.

Kessler, Elise L; Wang, Jiong-Wei; Kok, Bart; Brans, Maike A; Nederlof, Angelique; van Stuijvenberg, Leonie; Huang, Chenyuan; Vink, Aryan; Arslan, Fatih; Efimov, Igor R; Lam, Carolyn S P; Vos, Marc A; de Kleijn, Dominique P V; Fontes, Magda S C; van Veen, Toon A B.

Int J Mol Sci ; 22(21)2021 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-34769252

17.

p38Î´ genetic ablation protects female mice from anthracycline cardiotoxicity.

George, Sharon A; Kiss, Alexi; Obaid, Sofian N; Venegas, Aileen; Talapatra, Trisha; Wei, Chapman; Efimova, Tatiana; Efimov, Igor R.

Am J Physiol Heart Circ Physiol ; 319(4): H775-H786, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-32822209

18.

Role of angiotensin-converting enzyme 2 and pericytes in cardiac complications of COVID-19 infection.

Robinson, Fulton A; Mihealsick, Ryan P; Wagener, Brant M; Hanna, Peter; Poston, Megan D; Efimov, Igor R; Shivkumar, Kalyanam; Hoover, Donald B.

Am J Physiol Heart Circ Physiol ; 319(5): H1059-H1068, 2020 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-33036546

19.

Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity.

Miller, Jessica M; Meki, Moustafa H; Ou, Qinghui; George, Sharon A; Gams, Anna; Abouleisa, Riham R E; Tang, Xian-Liang; Ahern, Brooke M; Giridharan, Guruprasad A; El-Baz, Ayman; Hill, Bradford G; Satin, Jonathan; Conklin, Daniel J; Moslehi, Javid; Bolli, Roberto; Ribeiro, Alexandre J S; Efimov, Igor R; Mohamed, Tamer M A.

Toxicol Appl Pharmacol ; 406: 115213, 2020 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-32877659

20.

Flotillins in the intercalated disc are potential modulators of cardiac excitability.

Kessler, Elise L; van Stuijvenberg, Leonie; van Bavel, Joanne J A; van Bennekom, Joëlle; Zwartsen, Anne; Rivaud, Mathilde R; Vink, Aryan; Efimov, Igor R; Postma, Alex V; van Tintelen, J Peter; Remme, Carol A; Vos, Marc A; Banning, Antje; de Boer, Teun P; Tikkanen, Ritva; van Veen, Toon A B.

J Mol Cell Cardiol ; 126: 86-95, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30452906

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Instituto Evandro Chagas

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