Detalhe da pesquisa
1.
Pharmacokinetics and pharmacodynamics of finerenone in patients with chronic kidney disease and type 2 diabetes: Insights based on FIGARO-DKD and FIDELIO-DKD.
Diabetes Obes Metab
; 26(3): 924-936, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38037539
2.
NT-proBNP for Predicting All-Cause Death and Heart Transplant in Children and Adults with Heart Failure.
Pediatr Cardiol
; 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38722325
3.
Integration of physiological changes during the postpartum period into a PBPK framework and prediction of amoxicillin disposition before and shortly after delivery.
J Pharmacokinet Pharmacodyn
; 47(4): 341-359, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32748112
4.
A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.
J Pharmacokinet Pharmacodyn
; 45(2): 235-257, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29234936
5.
Systemic exposure to aflibercept after intravitreal injection in premature neonates with retinopathy of prematurity: results from the FIREFLEYE randomized phase 3 study.
Eye (Lond)
; 38(8): 1444-1453, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38200320
6.
The Pharmacokinetics of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone.
Clin Pharmacokinet
; 62(12): 1673-1693, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37875671
7.
Evaluating Kidney Function Decline in Children with Chronic Kidney Disease Using a Multi-Institutional Electronic Health Record Database.
Clin J Am Soc Nephrol
; 18(2): 173-182, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36754006
8.
Multiscale mechanistic modeling in pharmaceutical research and development.
Adv Exp Med Biol
; 736: 543-61, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22161351
9.
First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development.
J Pharmacokinet Pharmacodyn
; 39(2): 195-203, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22311388
10.
Physiologically-based pharmacokinetic modeling to predict CYP3A4-mediated drug-drug interactions of finerenone.
CPT Pharmacometrics Syst Pharmacol
; 11(2): 199-211, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34783193
11.
Dose-Exposure-Response Analysis of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone on UACR and eGFR: An Analysis from FIDELIO-DKD.
Clin Pharmacokinet
; 61(7): 1013-1025, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35508594
12.
Finerenone Dose-Exposure-Serum Potassium Response Analysis of FIDELIO-DKD Phase III: The Role of Dosing, Titration, and Inclusion Criteria.
Clin Pharmacokinet
; 61(3): 451-462, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34786651
13.
Finerenone Dose-Exposure-Response for the Primary Kidney Outcome in FIDELIO-DKD Phase III: Population Pharmacokinetic and Time-to-Event Analysis.
Clin Pharmacokinet
; 61(3): 439-450, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34773606
14.
Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes.
Transl Vis Sci Technol
; 10(4): 9, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34003985
15.
NT-proBNP Qualifies as a Surrogate for Clinical End Points in Heart Failure.
Clin Pharmacol Ther
; 110(2): 498-507, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33630302
16.
Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small-Molecule Compounds in Children.
J Clin Pharmacol
; 61 Suppl 1: S70-S82, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34185905
17.
A Physiologically-Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP-1 and GIP and the DPP4 Inhibitor Sitagliptin.
CPT Pharmacometrics Syst Pharmacol
; 9(6): 353-362, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32543789
18.
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim.
Front Pharmacol
; 11: 868, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32595502
19.
Population Pharmacokinetic and Exposure-Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease.
Clin Pharmacokinet
; 59(3): 359-370, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31583611
20.
Application of Physiologically-Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin.
CPT Pharmacometrics Syst Pharmacol
; 8(9): 654-663, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31310051