Detalhe da pesquisa
1.
Design, synthesis, antineoplastic activity of new pyrazolo[3,4-d]pyrimidine derivatives as dual CDK2/GSK3ß kinase inhibitors; molecular docking study, and ADME prediction.
Bioorg Chem
; 150: 107566, 2024 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38896936
2.
Rational design and synthesis of novel quinazolinone N-acetohydrazides as type II multi-kinase inhibitors and potential anticancer agents.
Bioorg Chem
; 142: 106920, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37898082
3.
Benzimidazole-oxindole hybrids as multi-kinase inhibitors targeting melanoma.
Bioorg Chem
; 146: 107243, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38457953
4.
Discovery of novel quinolin-2-one derivatives as potential GSK-3ß inhibitors for treatment of Alzheimer's disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation.
Bioorg Chem
; 146: 107324, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38569322
5.
In Silico and In Vitro Screening of Some Pregnane Glycosides Isolated from Certain Caralluma Species as SARS-COV-2 Main Protease Inhibitors.
Chem Biodivers
; 21(4): e202301786, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38466126
6.
Novel benzenesulfonamide-thiouracil conjugates with a flexible N-ethyl acetamide linker as selective CA IX and CA XII inhibitors.
Arch Pharm (Weinheim)
; 356(2): e2200434, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36372524
7.
Novel 2-oxo-2-phenylethoxy and benzyloxy diaryl urea hybrids as VEGFR-2 inhibitors: Design, synthesis, and anticancer evaluation.
Arch Pharm (Weinheim)
; 356(2): e2200341, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36398495
8.
New quinazolinone-based derivatives as DHFR/EGFR-TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity.
Arch Pharm (Weinheim)
; 356(1): e2200417, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36257809
9.
Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies.
Bioorg Med Chem Lett
; 58: 128529, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35007724
10.
Design, synthesis and anticancer activity of novel 2-arylbenzimidazole/2-thiopyrimidines and 2-thioquinazolin-4(3H)-ones conjugates as targeted RAF and VEGFR-2 kinases inhibitors.
Bioorg Chem
; 126: 105883, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35636123
11.
Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights.
J Enzyme Inhib Med Chem
; 37(1): 1227-1240, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35470754
12.
A Perspective Study on the RTK, PI3K, B-Raf, CDK and the Multi-Protein Targeting in Medicinal Chemistry.
Chem Biodivers
; 19(10): e202200328, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36066572
13.
Design and synthesis of novel quinazolinone-based fibrates as PPARα agonists with antihyperlipidemic activity.
Arch Pharm (Weinheim)
; 355(3): e2100399, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34958132
14.
Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activity.
Bioorg Chem
; 115: 105253, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34390973
15.
Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities.
Bioorg Chem
; 107: 104569, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33387732
16.
Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design, synthesis and in vitro/in vivo biological evaluation.
Bioorg Chem
; 115: 105170, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34332233
17.
Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3ß inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies.
J Enzyme Inhib Med Chem
; 36(1): 270-285, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33327806
18.
New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies.
Bioorg Med Chem
; 28(5): 115329, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32007388
19.
Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights.
Bioorg Med Chem
; 28(13): 115525, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32371117
20.
Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking.
Bioorg Chem
; 99: 103780, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32224337