Detalhe da pesquisa
1.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nat Immunol
; 16(4): 354-65, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25729923
2.
SAGA and SAGA-like SLIK transcriptional coactivators are structurally and biochemically equivalent.
J Biol Chem
; 296: 100671, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33864814
3.
Ligand-dependent spatiotemporal signaling profiles of the µ-opioid receptor are controlled by distinct protein-interaction networks.
J Biol Chem
; 294(44): 16198-16213, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31515267
4.
Stonefish toxin defines an ancient branch of the perforin-like superfamily.
Proc Natl Acad Sci U S A
; 112(50): 15360-5, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627714
5.
P-Rex1 and P-Rex2 RacGEFs and cancer.
Biochem Soc Trans
; 45(4): 963-77, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28710285
6.
Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export.
Mol Cell
; 33(6): 727-37, 2009 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328066
7.
Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease.
J Biol Chem
; 290(40): 24190-200, 2015 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26260925
8.
The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J Biol Chem
; 290(34): 20827-20840, 2015 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26112412
9.
Compartmentalization of GPCR signalling controls unique cellular responses.
Biochem Soc Trans
; 44(2): 562-7, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27068970
10.
High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.
BMC Struct Biol
; 14: 14, 2014 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24758516
11.
Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically 'actionable' signalling axis in triple negative breast cancer.
bioRxiv
; 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38405732
12.
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat Struct Mol Biol
; 29(8): 767-773, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35864164
13.
Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential.
Cell Chem Biol
; 29(4): 586-596.e4, 2022 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34699747
14.
Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.
J Biol Chem
; 285(6): 3850-3856, 2010 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20007317
15.
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1.
Nat Struct Mol Biol
; 28(12): 982-988, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34887559
16.
Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1.
Sci Signal
; 14(681)2021 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33947796
17.
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/ß-catenin signaling in breast cancer.
Nat Commun
; 12(1): 3140, 2021 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34035258
18.
Parsing the IL-37-Mediated Suppression of Inflammasome Function.
Cells
; 9(1)2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31936823
19.
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Nat Commun
; 11(1): 5794, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33188181
20.
Human embryonic stem cell models of Huntington disease.
Reprod Biomed Online
; 19(1): 106-13, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19573298