Detalhe da pesquisa
1.
The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription.
Cytogenet Genome Res
; 151(2): 72-81, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28433994
2.
A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor.
Blood
; 125(6): 1025-33, 2015 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25343958
3.
Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials.
Mol Ther
; 24(7): 1173-7, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27506378
4.
Long-term regulation of genetically modified primary hematopoietic cells in dogs.
Mol Ther
; 19(7): 1287-94, 2011 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21326218
5.
Poly(ADP-ribose) polymerase-1 (PARP-1) contributes to the barrier function of a vertebrate chromatin insulator.
J Biol Chem
; 285(48): 37589-97, 2010 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20876582
6.
Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.
Blood Cells Mol Dis
; 47(2): 107-16, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21641240
7.
Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy.
Hum Gene Ther
; 32(19-20): 1186-1199, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34477013
8.
Gene therapy for ß-thalassaemia: the continuing challenge.
Expert Rev Mol Med
; 12: e31, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20883576
9.
A functional screen for regulatory elements that improve retroviral vector gene expression.
Blood Cells Mol Dis
; 45(4): 343-50, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20846887
10.
Big changes coming to biosafety oversight of clinical gene transfer.
Mol Ther
; 22(8): 1402, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25082087
11.
Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.
Mol Ther
; 17(4): 716-24, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19240697
12.
Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects.
Hum Gene Ther
; 18(4): 333-43, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17411365
13.
Corrigendum to "Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs".
Mol Ther
; 19(11): 2102, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28160652
14.
Simultaneous sequence transfer into two independent locations of a reporter vector using MultiSite Gateway technology.
Biotechniques
; 39(4): 553-7, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16235567
15.
Use of CD9 expression to enrich for porcine hematopoietic progenitors.
Exp Hematol
; 30(7): 809-15, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12135680
16.
Functional validation of a constitutive autonomous silencer element.
PLoS One
; 10(4): e0124588, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25910277
17.
Genomic discovery of potent chromatin insulators for human gene therapy.
Nat Biotechnol
; 33(2): 198-203, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25580597
18.
Hematopoietic stem cell gene therapy.
Int J Hematol
; 75(3): 228-36, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11999349
19.
Identification and characterization of enhancer-blocking insulators to reduce retroviral vector genotoxicity.
PLoS One
; 8(10): e76528, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24098520
20.
Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites.
Hum Gene Ther
; 23(2): 231-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21981728