Detalhe da pesquisa
1.
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
Nature
; 589(7843): 608-614, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33408413
2.
Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.
Proc Natl Acad Sci U S A
; 120(7): e2206797120, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757889
3.
Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.
Proc Natl Acad Sci U S A
; 120(35): e2206612120, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37603758
4.
Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.
Am J Hum Genet
; 109(10): 1727-1741, 2022 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36055244
5.
Genetic effects on liver chromatin accessibility identify disease regulatory variants.
Am J Hum Genet
; 108(7): 1169-1189, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34038741
6.
Evaluation of musculoskeletal phenotype of the G608G progeria mouse model with lonafarnib, pravastatin, and zoledronic acid as treatment groups.
Proc Natl Acad Sci U S A
; 117(22): 12029-12040, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32404427
7.
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19.
Int J Obes (Lond)
; 46(8): 1478-1486, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35589964
8.
Base editor treats progeria in mice.
Nature
; 2021 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34285403
9.
Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle.
Proc Natl Acad Sci U S A
; 116(22): 10883-10888, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31076557
10.
Biotinylation by antibody recognition-a method for proximity labeling.
Nat Methods
; 15(2): 127-133, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29256494
11.
Super-enhancers delineate disease-associated regulatory nodes in T cells.
Nature
; 520(7548): 558-62, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686607
12.
Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts.
Proc Natl Acad Sci U S A
; 115(16): 4206-4211, 2018 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29581305
13.
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.
Proc Natl Acad Sci U S A
; 114(9): 2301-2306, 2017 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193859
14.
BoostMe accurately predicts DNA methylation values in whole-genome bisulfite sequencing of multiple human tissues.
BMC Genomics
; 19(1): 390, 2018 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29792182
15.
Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.
Genome Res
; 23(2): 260-9, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23152449
16.
Addendum: Biotinylation by antibody recognition-a method for proximity labeling.
Nat Methods
; 15(9): 749, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30054582
17.
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants.
Proc Natl Acad Sci U S A
; 110(44): 17921-6, 2013 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24127591
18.
Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories.
FASEB J
; 28(8): 3423-34, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24732130
19.
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing.
CRISPR J
; 7(1): 53-67, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38353623
20.
Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 hours.
bioRxiv
; 2023 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37333221