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Mycopathologia ; 185(3): 515-525, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32506392

RESUMO

Fungi of the genus Fusarium are well known as major plant pathogens but also cause a broad spectrum of human infections. Sixty-three clinical isolates, collected during 2014-2017, were identified using a part of the TEF1 gene as barcoding marker. Fusarium fujikuroi species complex (FFSC, n = 41, 65%) showed to be the dominant etiological agent, followed by F. solani species complex (FSSC, n = 14, 22%) and F. oxysporum species complex (FOSC, n = 7, 11%). There was one strain belonging to F. lateritium species complex (FLSC, n = 1, 1.5%). For final identification, a phylogenetic tree was constructed including the type strains of each species complex. Most cases of fusariosis were due to nail infection (n = 38, 60.3%), followed by keratitis (n = 22, 34%). Fusarium infections are difficult to be treated due to their intrinsic resistance to different azoles; however, accurate and fast identification of etiological agents may enhance management of the infection. We present the first phylogenetic study on clinical Fusarium spp. from Iran.


Assuntos
Fusariose/microbiologia , Fusarium/classificação , Ceratite/microbiologia , Onicomicose/microbiologia , Sequência Consenso , DNA Fúngico/química , DNA Fúngico/isolamento & purificação , Fusarium/genética , Humanos , Irã (Geográfico) , Funções Verossimilhança , Filogenia
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