1.
Thorax
; 79(2): 182-185, 2024 01 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38071573
RESUMO
Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) in individuals with rheumatoid arthritis (RA). This is the largest study to demonstrate and replicate that shortened peripheral blood leukocytes-TL is associated with ILD in patients with RA compared with RA without ILD in a multinational cohort, and short PBL-TL was associated with baseline disease severity in RA-ILD as measured by forced vital capacity percent predicted.
Assuntos
Artrite Reumatoide , Doenças Pulmonares Intersticiais , Humanos , Encurtamento do Telômero , Telômero/genética , Artrite Reumatoide/genética , Artrite Reumatoide/complicações , Doenças Pulmonares Intersticiais/complicações , Fumar
2.
J Bras Pneumol
; 46(6): e20200487, 2020 11 20.
Artigo
em Inglês, Português
| MEDLINE
| ID: mdl-33237156