Detalhe da pesquisa
1.
In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 58(3): 1652-63, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24379202
2.
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Bioorg Med Chem Lett
; 24(3): 917-22, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24412110
3.
Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity.
Retrovirology
; 10: 73, 2013 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23866860
4.
Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition.
J Biol Chem
; 286(34): 29575-83, 2011 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21737446
5.
3,4-Diarylpiperidines as potent renin inhibitors.
Bioorg Med Chem Lett
; 22(5): 1953-7, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22325946
6.
Design and synthesis of potent, isoxazole-containing renin inhibitors.
Bioorg Med Chem Lett
; 22(8): 2670-4, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22450130
7.
Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
J Med Chem
; 65(19): 13198-13215, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36126059
8.
Assessing protein-RNA interactions using microfluidic capillary mobility shift assays.
Anal Biochem
; 411(1): 161-3, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21130065
9.
Probing cathepsin S activity in whole blood by the activity-based probe BIL-DMK: cellular distribution in human leukocyte populations and evidence of diurnal modulation.
Anal Biochem
; 411(1): 43-9, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21094118
10.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines.
Bioorg Med Chem Lett
; 21(24): 7399-404, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22071301
11.
Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors.
Bioorg Med Chem Lett
; 21(21): 6505-9, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21924609
12.
The discovery and synthesis of potent zwitterionic inhibitors of renin.
Bioorg Med Chem Lett
; 21(8): 2430-6, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21429746
13.
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.
Bioorg Med Chem Lett
; 21(3): 920-3, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21232956
14.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.
Bioorg Med Chem Lett
; 21(13): 3976-81, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21641209
15.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.
Bioorg Med Chem Lett
; 21(13): 3970-5, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21621998
16.
2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.
Bioorg Med Chem Lett
; 20(22): 6366-9, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20933412
17.
Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).
Bioorg Med Chem Lett
; 20(2): 499-502, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004097
18.
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.
Bioorg Med Chem Lett
; 20(3): 887-92, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20061146
19.
Development of a homogeneous immunoassay for the detection of angiotensin I in plasma using AlphaLISA acceptor beads technology.
Anal Biochem
; 388(1): 134-9, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19258005
20.
Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.
Am J Respir Cell Mol Biol
; 39(1): 26-35, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18258919