1.
Cell Chem Biol
; 30(4): 340-342, 2023 04 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37084716
RESUMO
Targeted protein degradation using molecular glues is a powerful method for targeting traditionally undruggable proteins. One challenge in molecular glue discovery is the absence of rational discovery methods. Here, King et al. leverage covalent library screening with chemoproteomics platforms to rapidly discover a molecular glue targeting NFKB1 via UBE2D recruitment.