Detalhe da pesquisa
1.
Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.
EMBO J
; 39(8): e102811, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32175624
2.
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.
EMBO Rep
; 23(6): e53890, 2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35438230
3.
Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.
Acta Neuropathol
; 140(2): 121-142, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32562018
4.
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
Acta Neuropathol Commun
; 11(1): 112, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37434215
5.
Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD.
Cell Rep
; 39(10): 110913, 2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675776
6.
Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.
EMBO Mol Med
; 12(2): e10919, 2020 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31858749
7.
Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity.
Life Sci Alliance
; 1(2): e201800070, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30456350
8.
Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins.
EMBO Mol Med
; 9(5): 687-702, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28351931