Detalhe da pesquisa
1.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35065235
2.
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Nature
; 518(7539): 417-21, 2015 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25470037
3.
Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties.
Bioorg Med Chem Lett
; 26(18): 4455-4461, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27524313
4.
Experimental and Computational Studies of the Diastereoselective Alkylations of 3-Substituted γ-Sultams.
J Org Chem
; 80(1): 685-9, 2015 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25437310
5.
Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes.
J Org Chem
; 80(20): 10218-25, 2015 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26378765
6.
Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.
Bioorg Med Chem Lett
; 25(19): 4109-13, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26321361
7.
Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.
Bioorg Med Chem Lett
; 25(15): 2907-12, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048793
8.
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 25(1): 75-82, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466195
9.
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc Natl Acad Sci U S A
; 109(14): 5299-304, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431598
10.
Identification of tertiary sulfonamides as RORc inverse agonists.
Bioorg Med Chem Lett
; 24(9): 2182-7, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24685544
11.
Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.
Bioorg Med Chem Lett
; 24(16): 3891-7, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25017032
12.
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 24(24): 5683-5687, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25467161
13.
A reversed sulfonamide series of selective RORc inverse agonists.
Bioorg Med Chem Lett
; 24(24): 5769-5776, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453817
14.
Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 24(16): 3764-71, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25037916
15.
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.
Bioorg Med Chem Lett
; 23(24): 6604-9, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239186
16.
Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 23(20): 5533-9, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24012183
17.
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 23(11): 3186-94, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23628333
18.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.
Bioorg Med Chem Lett
; 22(14): 4907-11, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22704236
19.
Concise syntheses of (-)-galanthamine and (+/-)-codeine via intramolecular alkylation of a phenol derivative.
J Am Chem Soc
; 131(44): 16045-7, 2009 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19835379
20.
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
ACS Med Chem Lett
; 7(10): 896-901, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27774125