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1.
J Sports Sci ; 42(8): 728-736, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38858835

RESUMO

We investigated whether post-meal walking (PMW) improved post-prandial glucose and 24h glucose control under free-living conditions among physically inactive young women. METHODS: Young women (Age: 20±1years; percent body fat: 28.2 ± 12%; BMI: 23.8 ± 4.2kg·m-1) completed a randomised crossover study to assess if PMW confers benefit. On the PMW day, women completed three bouts of brisk walks, and on the Control day they were instructed to follow normal habitual activities. Continuous glucose monitors captured post-prandial and 24h glucose, and physical activity monitors tracked physical activity throughout the study. RESULTS: PMW walking increased total daily step count (Control = 9,159 ± 2,962 steps vs. PMW = 14,611±3,891 steps, p<0.001) and activity scores (Control=33.87±1.16 METs·h vs. PMW = 36.11±1.58 METs·h, p < 0.001). PMW led to lower 3h average post-prandial glucose (main effect of condition, p=0.011) and 3h post-prandial area under curve glucose responses (main effect of condition, p = 0.027) compared to the control condition. Post hoc analysis revealed the largest decline occurred after dinner (3h average glucose Control = 7.55±1.21 mmol/L vs. PMW = 6.71 ± 0.80mmol/L, p = 0.039), when insulin sensitivity is typically diminished. Despite improvements in post-prandial glucose control, this did not translate to improvements in 24h glucose control (p > 0.05). CONCLUSION: Physically inactive and metabolically healthy young women, PMW improves post-prandial glucose but not 24h glucose control.


Assuntos
Glicemia , Estudos Cross-Over , Período Pós-Prandial , Caminhada , Humanos , Período Pós-Prandial/fisiologia , Feminino , Glicemia/metabolismo , Adulto Jovem , Caminhada/fisiologia , Comportamento Sedentário , Controle Glicêmico
2.
J Strength Cond Res ; 38(2): 259-265, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-37815265

RESUMO

ABSTRACT: Rauseo, ML, Feairheller, DL, LaRoche, DP, and Cook, SB. Acute effect of dynamic and gluteal resistance exercise warm-up protocols on lower-extremity jump landing mechanics in college-aged females. J Strength Cond Res 38(2): 259-265, 2024-Inadequate neuromuscular control of the femur by the gluteal musculature is associated with noncontact and overuse injuries to the knee. Acute bouts of resistance exercises targeting the gluteal musculature can be prescribed as part of a warm-up protocol with the goal of improving subsequent neuromuscular control and performance. The purpose of this study was to determine the effect that a warm-up protocol including moderate-intensity gluteal resistance exercises (GRE) has on single leg jump landing biomechanics. Seventeen healthy, college-aged, recreationally active females (mean ± SD ; age = 21.4 ± 1.9 years; height = 166.9 ± 5.7 cm; body mass = 62.5 ± 7.4 kg) performed 3 single leg hop trials per leg after completing no warm-up (CON), a dynamic warm-up (DWU), and a dynamic warm-up with gluteal resistance exercises (DWU + GRE) across 3 laboratory visits. Lower extremity kinetic and kinematic variables were assessed during single leg hops from the point of initial foot contact to deepest knee flexion. Biomechanical differences between dominant and nondominant limb landings were also assessed. Dominant limb hip internal rotation angle after DWU + GRE (2.03 ± 9.92°) was significantly greater ( p ≤ 0.05) compared with CON (-3.36 ± 7.74°). Peak knee adduction moment (56.8%), peak knee flexion angle (5.7%), and peak knee external rotation angle (17.0%) were significantly greater ( p ≤ 0.017) in the dominant limb, compared with the nondominant limb, across warm-up protocols. The combined DWU + GRE warm-up protocol did not have a substantial impact on landing biomechanics. Clinicians prescribing GRE before activity should not expect significant changes in movement patterns after a single bout.


Assuntos
Lesões do Ligamento Cruzado Anterior , Treinamento Resistido , Humanos , Feminino , Adulto Jovem , Adulto , Articulação do Joelho , Extremidade Inferior , Joelho , Fenômenos Biomecânicos , Movimento
3.
Blood Press ; 32(1): 2161997, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-36597210

RESUMO

BACKGROUND: Impaired cardiovascular health is a concern for firefighters, with over 50% of line-of-duty deaths having cardiac causes. Many firefighters have hypertension and <25% have their blood pressure (BP) controlled. The alarm response could be an unidentified cardiac risk, but interestingly, the BP response to different calls and on-the-job activity is unknown. PURPOSE: We aimed to measure the physiological stress resulting from different call types (fire, medical) and job activity (riding apparatus, pre-alert alarms) through ambulatory BP (ABP) monitoring in a population of firefighters. MATERIALS AND METHODS: During 111 12-h work shifts firefighters wore an ABP monitor. BP was measured at 30-min intervals and manual measurements were prompted when the pager went off or whenever they felt stress. RESULTS: Firefighters were hypertensive (124.3 ± 9.9/78.1 ± 6.7 mmHg), overweight (30.2 ± 4.6 kg/m2), middle-aged (40.5 ± 12.6 years) and experienced (17.3 ± 11.7 years). We calculated an average 11% increase in systolic and 10.5% increase in diastolic BP with alarm. Systolic BP (141.9 ± 13.2 mmHg) and diastolic BP (84.9 ± 11.1 mmHg) and the BP surges were higher while firefighters were responding to medical calls compared to fire calls. Between BP groups we found that medical call systolic BP (p = .001, d = 1.2), diastolic BP (p = .017, d = 0.87), and fire call systolic BP (p = .03, d = 0.51) levels were higher in the hypertensive firefighters. CONCLUSION: This is the first report of BP surge responses to alarms and to occupational activities in firefighters, and medical calls elicited the largest overall responses.PLAIN LANGUAGE SUMMARYCardiovascular disease and impaired cardiovascular health are substantially more prevalent in firefighters, with over 50% of line-of-duty deaths being cardiac related.Many firefighters are diagnosed with high blood pressure (hypertension), which is known to increase the risk of heart attacks, strokes, heart disease, and other serious health complications.Upon stress, our body enacts the 'fight or flight' response where sympathetic nervous system activity triggers an immediate increase in heart rate and blood pressure. This response can be dangerous when surges reach extreme levels due to underlying impaired cardiovascular function. It is known that alarm sounds trigger a stress response.Firefighters respond to different alarms while on the job, each indicating different call types, such as a house fire or a medical emergency. Due to the prevalence of impaired cardiovascular health in firefighters, the physical stress resulting from these alerts is cause for concern.The blood pressure surge response to different call types and job activities in healthy and hypertensive firefighters had not been measured before this study.Through the ambulatory blood pressure monitoring of 111 on-duty firefighters, this study discovered that medical calls caused the greatest blood pressure and heart rate surge.Also, firefighters with hypertension experienced a greater blood pressure surge in response to alarms than their non-hypertensive co-workers.


Assuntos
Bombeiros , Hipertensão , Acidente Vascular Cerebral , Pessoa de Meia-Idade , Humanos , Pressão Sanguínea/fisiologia , Monitorização Ambulatorial da Pressão Arterial , Hipertensão/etiologia , Hipertensão/complicações
4.
J Strength Cond Res ; 32(6): 1662-1670, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28723820

RESUMO

McClelland, JM, Godek, SF, Chlad, PS, Feairheller, DL, and Morrison, KE. Effects of cardiovascular fitness and body composition on maximal core temperature in collegiate football players during preseason. J Strength Cond Res 32(6): 1662-1670, 2018-This study evaluated the effects of body mass index (BMI) and aerobic fitness (V[Combining Dot Above]O2max) on maximal core temperature values (Tcmax) in 17 National Collegiate Athletic Association Division III football players during preseason. The subjects included 9 backs (BKs) and 8 linemen (LM). V[Combining Dot Above]O2max testing was performed 1 week before preseason. Core temperature was monitored by ingestible sensor every 10 minutes during practices on day 4 (D1), day 5 (D2), day 7 (D3), and postacclimatization on day 14 (D4). Wet bulb globe temperature (WBGT) was recorded on each collection day. Independent, paired t-tests and Pearson's correlations were performed (α = 0.05). There were no significant correlations between V[Combining Dot Above]O2max and Tcmax on D1 (WBGT = 29.07° C) or D2 (WBGT = 30.93° C), but on D3 (WBGT = 31.39° C) there was a nonsignificant moderate negative correlation (r = -0.564, p = 0.090). There were no significant correlations between BMI and Tcmax on D1 or D2, but on D3 there was a nonsignificant moderate positive correlation (r = 0.596, p = 0.069). Paired t-tests revealed that overall Tcmax (D1-3) (38.56 ± 0.32° C) was statistically higher (p = 0.002) than D4 (38.16 ± 0.30° C). Independent t-tests between groups showed that the Tcmax values during preacclimatization (D1-D3) were significantly higher in LM (38.50 ± 0.37° C) than BKs (38.16 ± 0.35° C) (p = 0.007). V[Combining Dot Above]O2max was significantly lower (p = 0.006) in LM (36.89 ± 6.40 ml·kg·min) than BKs (47.44 ± 7.09 ml·kg·min), and BMI was significantly higher (p = 0.019) in LM (35.59 ± 4.00 kg·m) than BKs (28.68 ± 3.38 kg·m). The results of this study demonstrate that LM are significantly less fit than BKs and have a greater BMI. When WBGT was the highest on D3, the results suggest that those with lower V[Combining Dot Above]O2max and higher BMI experienced a higher Tcmax.


Assuntos
Índice de Massa Corporal , Temperatura Corporal , Fenômenos Fisiológicos Cardiovasculares , Futebol Americano/fisiologia , Consumo de Oxigênio , Aptidão Física , Aclimatação , Regulação da Temperatura Corporal , Exercício Físico , Teste de Esforço , Temperatura Alta , Humanos , Masculino , Condicionamento Físico Humano/fisiologia , Universidades , Adulto Jovem
5.
Ethn Dis ; 27(3): 233-240, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28811734

RESUMO

PURPOSE: Systemic inflammation, measured by C-reactive protein (CRP), is an important risk factor for cardiovascular disease (CVD) and mortality. We investigated whether aerobic exercise training (AEXT) affects African Americans with high inflammation (HI) the same way it does African Americans with low inflammation (LI) in terms of CVD risk factors. METHODS: 23 African Americans with CRP levels <3 mg/L (LI) and 14 African Americans with CRP ≥3 mg/L (HI) underwent six months of AEXT. Participants were sedentary, non-diabetic, non-smoking, with clinical blood pressure <160/100 mm Hg, were non-hyperlipidemic, had no signs of cardiovascular, renal, or pulmonary disease, and were not on medication. Measures included CD62E+ endothelial microparticles (EMPs), a measure of early stage endothelial dysfunction, as well as lipid and glucose profile, aerobic fitness, body composition, and blood pressure. RESULTS: The LI group improved aerobic fitness by 10%, body mass index by 3%, and plasma triglycerides by 20%, with no change being observed in HI group for these variables. The HI group improved fasting plasma glucose levels by 10%, with no change occurring in the LI group. Both groups improved CD62E+ EMPs by 38% and 59% for the LI and HI group, respectively. CONCLUSIONS: A standard AEXT intervention differentially affected CVD risk factors among African Americans with high and low inflammation. This may indicate that, in African Americans with high inflammation, AEXT alone may not be enough to reap the same benefits as their low-inflammation peers in terms of CVD risk modification.


Assuntos
Negro ou Afro-Americano , Pressão Sanguínea/fisiologia , Proteína C-Reativa/metabolismo , Terapia por Exercício/métodos , Exercício Físico/fisiologia , Inflamação/reabilitação , Triglicerídeos/sangue , Adulto , Idoso , Composição Corporal , Índice de Massa Corporal , Feminino , Humanos , Incidência , Inflamação/sangue , Inflamação/etnologia , Masculino , Pessoa de Meia-Idade , Pennsylvania/epidemiologia , Fatores de Risco
6.
Int J Exerc Sci ; 17(4): 285-297, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38665856

RESUMO

Tactical populations face increased risk on the job, and it is known that firefighters have high levels of cardiac-related death. Aerobic fitness is a modifiable cardiac risk factor, but many fire stations lack the proper equipment to easily assess aerobic fitness levels of their firefighters. Additionally, many fire stations lack wellness programs to hold firefighters accountable for maintaining their fitness levels. Purpose: We assessed the validity of the submaximal 6-minute walk test (6MWT) as a measure of aerobic capacity compared to a maximal treadmill test and the submaximal Gerkin protocol. Methods: Twenty-four firefighters (19 male, 5 female, 34.8 ± 9.7 years; 38.1 ± 3.6 kg·m-2) completed the 6MWT, the submaximal Gerkin protocol, and a maximal treadmill test. Data were analyzed with Bland-Altman plots and correlation analysis. Results: We found equivalence between the 6MWT and directly measured VO2max and between the 6MWT and Gerkin protocol using Bland-Altman plots. In our cohort, the 6MWT underestimated VO2max (31.57 ml·kg-1·min-1) compared to directly measured VO2max (38.1 ml·kg-1·min-1) by 17% and to the Gerkin (40.48 ml·kg-1·min-1) by 22%. Conclusion: Considering its equivalence, using the 6MWT could be a more accessible way to quantify aerobic capacity in firefighters. Despite underestimation, having an easy to administer protocol may encourage more fire stations to assess pre- and post- fitness levels regularly.

7.
Exerc Sport Sci Rev ; 41(1): 44-54, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23262464

RESUMO

African Americans have an endothelial dysfunction that likely contributes to their high prevalence of hypertension. Endothelial cell (EC) responses to stimuli could play a role in the development of endothelial dysfunction and hypertension. High physiological levels of vascular laminar shear stress can alter EC phenotype profoundly. It is not known whether there are race-dependent EC responses to laminar shear stress.


Assuntos
Negro ou Afro-Americano , Células Endoteliais/fisiologia , Exercício Físico/fisiologia , Disparidades nos Níveis de Saúde , Doenças Vasculares/etnologia , População Branca , Biomarcadores/metabolismo , Células Endoteliais/metabolismo , Humanos , Inflamação/etnologia , Inflamação/metabolismo , Inflamação/fisiopatologia , Óxido Nítrico/metabolismo , Óxido Nítrico Sintase/metabolismo , Estresse Oxidativo/fisiologia , Estresse Fisiológico/fisiologia , Doenças Vasculares/metabolismo , Doenças Vasculares/fisiopatologia
8.
Blood Press Monit ; 28(3): 134-143, 2023 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-37070561

RESUMO

BACKGROUND: Cardiac-related incidents are a public health concern for tactical occupations, and cardiovascular disease rates are higher in these populations compared with civilians. Research is needed to examine blood pressure (BP) responses in firefighters. The pager alert is one occupational hazard, and it is unknown if lifestyle change can reduce the systolic surge response. PURPOSE: To measure BP surge with alarm in firefighters to determine whether the magnitude is lower after a 6-week tactical exercise and Mediterranean-diet intervention. METHODS: SBP and DBP and BP surge levels, circulating markers, vascular health, and fitness were analyzed. BP surge with alarm was captured during a 12-hour workshift. Exercise and diet were self-reported. Diet was tracked with diet scores based on number of servings. RESULTS: Twenty five firefighters (43.4 ±â€…13.9 years) participated. We found changes in the magnitude of BP surge with alarm (SBP surge from16.7 ±â€…12.9 to 10.5 ±â€…11.7 mmHg, P < 0.05; DBP surge from 8.2 ±â€…10.8 to 4.9 ±â€…5.6 mmHg, P > 0.05) after intervention. We confirm that clinical (127.6 ±â€…9.1 to 120 ±â€…8.2 mmHg) and central (122.7 ±â€…11.3 to 118.2 ±â€…10.7 mmHg) SBP levels improve with exercise and diet. We report for the first time in firefighters that oxidative stress markers superoxide dismutase (9.1 ±â€…1.5 to 11.2 ±â€…2.2 U/ml) and nitric oxide (40.4 ±â€…7 to 48.9 ±â€…16.9 µmol/l) levels improve with an exercise and diet intervention. CONCLUSION: These findings have implications toward the benefit that short-term lifestyle changes make toward reducing the alarm stress response in first responders.


Assuntos
Bombeiros , Hipertensão , Humanos , Pressão Sanguínea/fisiologia , Monitorização Ambulatorial da Pressão Arterial , Estilo de Vida , Exercício Físico
9.
Curr Hypertens Rev ; 18(2): 145-152, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34979891

RESUMO

Blood pressure (BP) responses are controlled by various factors and understanding how BP changes is important to occupational health. This paper presents a review of the literature that reports BP responses in the firefighter population. Hypertension is one of the main risk factors underlying the pathophysiology of cardiovascular disease (CVD), and cardiac incidents remain the leading cause of line-of-duty deaths in firefighters. Risk factors for line-of-duty deaths include obesity, previous or underlying heart disease, and hypertension. The occupation of firefighting is one of the most hazardous and dangerous jobs, yet over 50 % of firefighters are volunteers. Tactical operations and the hazardous nature of firefighting are exposures that influence stress responses and, therefore, affect BP. In fact, hypertension in firefighters often remains undocumented or undiagnosed. CVD risk and elevated BP in tactical populations, like firefighters, maybe a combination of physical and emotional stress due to the nature of the job. Cross-sectional studies have reported that firefighters have higher levels of BP and higher rates of hypertension compared to civilians. Interestingly, there is a limited amount of research that reports BP values before and after firefighting- related activities, and very few studies on interventional changes in BP. Here, we synthesize the literature on firefighting and provide a summary of the studies that report pre- and post- BP levels that relate to CVD risk factors, occupational factors, firefighting activities, and the data on exercise training and BP. More studies are needed that examine BP in firefighters and report on the changes in BP with occupational activities.


Assuntos
Bombeiros , Hipertensão , Humanos , Pressão Sanguínea , Estudos Transversais , Exercício Físico , Hipertensão/diagnóstico , Hipertensão/epidemiologia , Hipertensão/etiologia
10.
Int J Telerehabil ; 14(1): e6458, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35734390

RESUMO

Introduction: Firefighters have a high risk of cardiovascular incidence due to their poor health, fitness, and dietary habits. The purpose of this study was to examine the feasibility of a diet and exercise intervention within firefighters delivered exclusively via telehealth to help reduce the risks of cardiovascular disease. Additionally, the firefighters' perception of their health was assessed. Methods: Fifteen firefighters participated in a six-week Mediterranean diet and a functional circuit exercise intervention with pre- and post-fitness testing and survey completion. The firefighters had weekly video calls with their telehealth coach. Results: Self-assessed health improved with the intervention from an average of 5.9 to 7.9 out of 10. Both weight and BMI significantly decreased with the intervention. Overall, firefighters had high adherence to both portions of the intervention. Discussion: Telehealth interventions may be efficacious in improving firefighter fitness levels and overall health as firefighters saw positive health and fitness improvements.

11.
J Occup Environ Med ; 64(6): 488-494, 2022 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-34985026

RESUMO

OBJECTIVE: To examine the relationship between diet adherence and cardiovascular disease (CVD) risk-reduction between civilians and firefighters with a 6-week Mediterranean diet and tactical training intervention. METHODS: Forty firefighters and 30 civilians participated. Blood pressure, body composition, lipid levels, vascular measures, and aerobic capacity were measured pre- and post-intervention. Diet was self-report based on number of servings consumed. Weekly diet-scores were calculated. RESULTS: Both groups had improvements in blood pressure and body composition. Civilians had improved lipid levels, higher overall adherence, a relationship between total Med-diet score and cholesterol (R = 0.68), and higher servings consumed in foods typical of Mediterranean-dietary pattern ( P < 0.05). CONCLUSION: This is the first exercise and diet intervention comparing firefighters to civilians. Adherence to a Mediterranean-dietary pattern coupled with exercise is effective at improving cardiac health. These findings substantiate the need for wellness interventions in firefighters.


Assuntos
Doenças Cardiovasculares , Exercícios em Circuitos , Dieta Mediterrânea , Bombeiros , Doenças Cardiovasculares/prevenção & controle , Colesterol , Humanos
12.
J Exerc Physiol Online ; 14(1): 49-59, 2011 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-21691463

RESUMO

African Americans have disproportionate levels of cardiovascular disease and oxidative stress. The purpose of our study was to examine racial differences between African American and Caucasian adults in time-course oxidative stress responses to a treadmill test. After a 12-hr fast, 18 participants (9 of each ethnic group; 21 ± 0.4 yrs) completed a submaximal treadmill test and underwent serial blood draws: Pre, Post (within 2 min), 30, 60, and 120 min after exercise. At each time-point, superoxide dismutase (SOD, U/mL), total antioxidant capacity (TAC, mM), protein carbonyls (PC, nmol/mg), and thiobarbituric acid-reactive substance (TBARs, µmol/L) were measured. We found no difference between groups for blood pressure, BMI, or exercise capacity (as measured by volume of oxygen consumed, VO(2) max). African Americans had significantly (p < 0.05) higher SOD (Pre: 5.45 ± 0.4 vs. 3.69 ± 0.69; 60 min: 8.99 ± 0.7 vs. 4.23 ± 0.6; 120 min: 9.69 ± 1.6 vs. 3.52 ± 0.7), TAC (Pre: 2.31 ± 0.25 vs. 1.16 ± 0.3; Post: 2.39 ± 0.2 vs. 1.34 ± 0.2; 30 min: 2.29 ± 0.2 vs. 1.09 ± 0.2), and PC (Pre: 1.09 ± 0.1 vs. 0.82 ± 0.1; Post: 1.14 ± 0.1 vs. 0.81 ± 0.1; 30 min: 1.13 ± 0.1 vs. 0.85 ± 0.1; 60 min: 1.06 ± 0.1 vs. 0.81 ± 0.05), but not TBARs. Between groups, only SOD exhibited a different time-course response: levels for African Americans rose steadily throughout the 120 min, while levels for Caucasians peaked at 30 min and by 120 min had returned to pre-exercise levels. Race had a greater effect on oxidative stress responses than submaximal exercise did. African Americans had significantly higher TAC, SOD, and PC levels compared to Caucasians.

13.
Int J Exerc Sci ; 14(3): 1320-1333, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-35096239

RESUMO

Exercise training is known to reduce CVD risk factors; however, in tactical populations, like veterans and firefighters, the effects of different forms of exercise such as tactical circuit training (CT) or conventional resistance training (RT) is unclear. Thus, the purpose of this study was to compare changes in various CVD risk measures after 4-week tactical CT or RT programs. Thirty-seven firefighters (20 CT, 17 RT), 35% of whom were veterans, participated. Pre- and post-intervention measures included body fat (BF%), carotid artery intima media thickness (IMT), central and brachial BP, and indices of arterial stiffness (augmentation index, Aix@75), myocardial oxygenation (subendocardial viability ratio, SEVR), and endothelial function (flow-mediated dilation, FMD). Estimation of maximum oxygen consumption (VO2peak) for aerobic fitness, balance, muscular endurance, and strength were also compared. For the clinical laboratory values, there were no between group differences and the only within group change was found in triglyceride levels. Tactical CT lowered triglyceride levels by 24.2% (P < 0.05). Only tactical CT exercise lowered BP. Both brachial (4.6% reduction) and central (4.4 % reduction) systolic and diastolic SBP and DBP decreased with CT (all P ≤ 0.01). After training we found improvements in FMD and SEVR with tactical CT only. Percent FMD increased by 28.7% (P < 0.01) while SEVR increased by 4.4% (P < 0.05) in the tactical CT group. Fitness improved in both cohorts (P < 0.05). These data suggest that 4 weeks of a CT program improves several CVD-risk factors and may be more beneficial.

14.
Kidney Blood Press Res ; 33(4): 282-90, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20628261

RESUMO

AIMS: African-Americans, in particular women, exhibit disproportionate levels of hypertension, inflammation, and oxidative stress compared to other ethnic groups. The relationship between prehypertension, renal function, inflammation, and oxidative stress was examined. METHODS: Twenty-eight African-American women (53.5 +/- 1.1 years) followed an AHA diet and then underwent 24-hour ambulatory BP (ABP) monitoring. Urinary albumin (uAlb), serum and urinary creatinine, glomerular filtration rate (GFR), 24-hour urinary Na(+) excretion, plasma superoxide dismutase, total antioxidant capacity (TAC), urinary (uNOx) and plasma (pNOx) nitric oxide levels, and high-sensitivity C-reactive protein (hsCRP) were measured. RESULTS: When the group was divided by average 24-hour ABP into optimal and nonoptimal groups, a significant difference existed between the groups for uNOx (p = 0.001; nonoptimal: 933.5 +/- 140.4, optimal: 425.0 +/- 52.6 mumol/gCr), and for hsCRP (p = 0.018, nonoptimal: 3.9 +/- 0.7, optimal: 1.9 +/- 0.6 mg/l). Significant inverse relationships existed between hsCRP and uNOx and between uAlb and pNOx in the non-optimal group, between GFR and pNOx in the entire group, and positive association existed between TAC and uNOx in the optimal group. CONCLUSIONS: These results suggest that in African-American women as BP levels rise toward hypertension, the NO/NOS balance may be associated with renal function, and may have implications for CV risk based on their hsCRP levels.


Assuntos
Negro ou Afro-Americano/estatística & dados numéricos , Rim/fisiologia , Óxido Nítrico/metabolismo , Pré-Hipertensão/etnologia , Pré-Hipertensão/metabolismo , Albuminúria/etnologia , Albuminúria/metabolismo , Albuminúria/fisiopatologia , Proteína C-Reativa/metabolismo , Feminino , Taxa de Filtração Glomerular , Humanos , Hipertensão Renal/etnologia , Hipertensão Renal/metabolismo , Hipertensão Renal/fisiopatologia , Incidência , Pessoa de Meia-Idade , Estresse Oxidativo/fisiologia , Pré-Hipertensão/fisiopatologia , Prevalência , Fatores de Risco , Superóxido Dismutase/sangue
15.
Ethn Dis ; 20(4): 403-8, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21305829

RESUMO

OBJECTIVE: To examine the interaction of oxidative stress biomarkers with age, and also factors that influence oxidative stress such as body mass index (BMI) and fitness in a population of individuals with established higher risk of cardiovascular disease, African Americans. METHODS: Blood samples were obtained from healthy college-age and middle-age to older African Americans. Participants underwent a graded exercise test. Superoxide dismutase (SOD) activity, total antioxidant capacity and thiobarbituric acid reactive substances (TBARS) levels were measured. RESULTS: TBARS levels were significantly (P = .001) lower in young participants relative to middle-age to older participants. SOD activity was significantly (P = .001) lower in middle-age to older participants with low fitness relative to participants with normal fitness, and lower (P = .04) in middle-age to older participants that were overweight relative to normal weight participants. DISCUSSION: In a healthy middle-age to older population of African Americans, BMI and fitness are crucial for maintaining a healthy endothelium.


Assuntos
Negro ou Afro-Americano/estatística & dados numéricos , Estresse Oxidativo/fisiologia , Adolescente , Adulto , Fatores Etários , Idoso , Biomarcadores/análise , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Aptidão Física/fisiologia , Fatores de Risco , Superóxido Dismutase/análise , Substâncias Reativas com Ácido Tiobarbitúrico/análise , Adulto Jovem
16.
Prev Med Rep ; 10: 106-112, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29850395

RESUMO

As the global burden of cardiovascular disease (CVD) rises, public health-related interventions aimed at prevention of heart disease have gained medical attention. Clinical research reports that exercise is a protective risk factor associated with CVD and that clinicians need to provide exercise recommendations to patients. Nevertheless, physical inactivity remains a public health problem. In certain populations, like firefighters (FF), increased risk of CVD is especially concerning. The workload FF face is extreme, 50% of line-of-duty deaths (LODD) in FF are cardiac-related, and research on the volunteer FF population is scarce. Government regulations do not require volunteer FF companies to have fitness testing or programming, so exercise intervention studies are necessary to improve the burden of CVD risk in this population. Therefore, this study examined the effects of a 4-week exercise circuit training (CT) intervention on vascular health and fitness in volunteer FF (N = 27) from the Philadelphia PA area compared to a control group of Non-FF (N = 25). Carotid artery intima-media thickness (IMT), brachial artery flow-mediated dilation (FMD), augmentation index, and pulse pressure (PP), brachial and central blood pressure (BP) and fitness were measured pre- and post- intervention. Overall, volunteer FF had more significant improvements (p < 0.05) in vascular health measures (FMD, IMT, and PP). In both groups, we also found that brachial and central BP decreased with exercise. We show that a 4 week CT program can improve vascular structure and function in the volunteer FF population, suggesting that clinicians may be able to reduce or prevent cardiac LODD by exercise.

17.
Int J Exerc Sci ; 10(2): 246-257, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28344738

RESUMO

Improvements in indices of vascular health and endothelial function have been inversely associated with hypertension, a risk factor for cardiovascular disease (e.g., myocardial infarction, stroke, and heart failure), renal failure, and mortality. Aerobic exercise training (AEXT) has been positively associated with improvements in clinical health values, as well as vascular health biomarkers, and endothelial function. The purpose of this study was to evaluate whether measures of exercise adherence were related to clinical outcome measures and indices of vascular health subsequent to a 6-month AEXT intervention in a middle-to-older aged African American cohort. Following dietary stabilization, sedentary, apparently healthy, African American adults (40 - 71 y/o) underwent baseline testing including blood pressure, flow-mediated dilation (FMD) studies, fasting blood sampling, and graded exercise testing. Upon completion of a supervised 6-month AEXT intervention, participants repeated all baseline tests. Exercise adherence was measured three ways: exercise percentage, exercise volume, and exercise score. There were no significant correlations between the changes in the vascular health biomarkers of the participants and any of the adherence measures. In addition, there were no significant correlations between any of the adherence measures and the clinical values of the participants that had been significantly changed pre-post-AEXT. Participants improved their clinical and vascular health and decreased risk factors for hypertension and cardiovascular disease regardless of their level of adherence to AEXT. Future studies should continue to accurately quantify adherence in order to assess the exercise dose for improvements in vascular and clinical health.

18.
J Occup Environ Med ; 59(4): e20-e23, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-28628053

RESUMO

OBJECTIVE: To compare the effects of personal protective equipment (PPE) weight on blood pressure (BP) and heart rate (HR), between volunteer firefighters (FF) and athletes. METHODS: Athletes and FF were matched by body size and came to the lab twice for two treadmill tests. The "Regular" test was completed in normal fitness clothing, and PPE test was completed in full structural PPE with monitoring of HR assessment every minute and BP each stage. RESULTS: In the FF cohort, all submaximal HR and BP levels were different. HRmax and VO2max were also different (all P < 0.05). In athletes, HRmax was higher in Regular test than PPE. CONCLUSIONS: Future research should examine the effect of different PPE weights on HR and BP responses.


Assuntos
Bombeiros , Equipamento de Proteção Individual , Esforço Físico/fisiologia , Suporte de Carga/fisiologia , Pressão Sanguínea , Teste de Esforço , Futebol Americano/fisiologia , Frequência Cardíaca , Humanos , Masculino , Consumo de Oxigênio , Esportes com Raquete/fisiologia , Carga de Trabalho , Adulto Jovem
19.
Int J Exerc Sci ; 9(3): 482-490, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27766134

RESUMO

Previous studies have investigated carotid artery intima-media thickness (IMT) and blood pressure and found a direct correlation between the two. It is known that adult females have better cardiovascular health than males until a certain stage of life, yet limited research has examined gender differences in vascular function. Thus, the purpose of this study was to investigate vascular structure and function, blood pressure, and blood glucose/cholesterol levels in relation to gender differences in young healthy adults. On three separate days, 44 adults (26.30 ± 11.9yrs; 24M, 20F) completed a carotid IMT ultrasound, a flow-mediated dilation (FMD), a fasted glucose and cholesterol test, a 24hr ambulatory blood pressure monitoring, a VO2max test, and a body composition measurement. Females had lower systolic blood pressure, lower diastolic blood pressure, lower LDL/HDL ratios, lower body mass index, a higher HDL count, and lower plasma glucose levels than males (p < 0.05 for all), all of which suggest better cardiovascular health. However, we found no gender differences in vascular health measures, IMT and FMD. Our results suggest that while young adult females have better cardiovascular health than males, endothelial function may not yet be affected in the young adult years.

20.
Int J Vasc Med ; 2016: 6851256, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26904291

RESUMO

Studies report that football players have high blood pressure (BP) and increased cardiovascular risk. There are over 70,000 NCAA football players and 450 Division III schools sponsor football programs, yet limited research exists on vascular health of athletes. This study aimed to compare vascular and cardiovascular health measures between football players and nonathlete controls. Twenty-three athletes and 19 nonathletes participated. Vascular health measures included flow-mediated dilation (FMD) and carotid artery intima-media thickness (IMT). Cardiovascular measures included clinic and 24 hr BP levels, body composition, VO2 max, and fasting glucose/cholesterol levels. Compared to controls, football players had a worse vascular and cardiovascular profile. Football players had thicker carotid artery IMT (0.49 ± 0.06 mm versus 0.46 ± 0.07 mm) and larger brachial artery diameter during FMD (4.3 ± 0.5 mm versus 3.7 ± 0.6 mm), but no difference in percent FMD. Systolic BP was significantly higher in football players at all measurements: resting (128.2 ± 6.4 mmHg versus 122.4 ± 6.8 mmHg), submaximal exercise (150.4 ± 18.8 mmHg versus 137.3 ± 9.5 mmHg), maximal exercise (211.3 ± 25.9 mmHg versus 191.4 ± 19.2 mmHg), and 24-hour BP (124.9 ± 6.3 mmHg versus 109.8 ± 3.7 mmHg). Football players also had higher fasting glucose (91.6 ± 6.5 mg/dL versus 86.6 ± 5.8 mg/dL), lower HDL (36.5 ± 11.2 mg/dL versus 47.1 ± 14.8 mg/dL), and higher body fat percentage (29.2 ± 7.9% versus 23.2 ± 7.0%). Division III collegiate football players remain an understudied population and may be at increased cardiovascular risk.

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