Detalhe da pesquisa
1.
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-ß pathology.
Cell Mol Life Sci
; 80(7): 178, 2023 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306762
2.
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Brain Behav Immun
; 109: 1-22, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36584795
3.
Anti-Amyloid Therapies for Alzheimer's Disease and the Amyloid Cascade Hypothesis.
Int J Mol Sci
; 24(19)2023 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37833948
4.
MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases.
Int J Mol Sci
; 23(9)2022 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35563107
5.
A New Bistable Switch Model of Alzheimer's Disease Pathogenesis.
Int J Mol Sci
; 23(13)2022 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35806088
6.
Nearly 30 Years of Animal Models to Study Amyotrophic Lateral Sclerosis: A Historical Overview and Future Perspectives.
Int J Mol Sci
; 22(22)2021 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34830115
7.
Acute and Chronic Dopaminergic Depletion Differently Affect Motor Thalamic Function.
Int J Mol Sci
; 21(8)2020 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32326424
8.
Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites.
J Neurochem
; 150(3): 264-281, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31148170
9.
The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents.
J Pharmacol Exp Ther
; 371(3): 633-641, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31578258
10.
Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression.
Int J Mol Sci
; 20(18)2019 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31540330
11.
Amyloid-ß Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory.
J Neurosci
; 37(29): 6926-6937, 2017 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28626017
12.
Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.
Neurobiol Dis
; 74: 314-24, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25497732
13.
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.
Ann Neurol
; 75(4): 602-7, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24591104
14.
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors.
Bioorg Med Chem
; 23(13): 3426-35, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25936260
15.
Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition.
Neurotherapeutics
; : e00372, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38760316
16.
Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-ß precursor protein metabolism.
IUBMB Life
; 65(2): 127-33, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23297063
17.
Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue.
Biofactors
; 48(5): 1111-1117, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35561079
18.
Memory Enhancers for Alzheimer's Dementia: Focus on cGMP.
Pharmaceuticals (Basel)
; 14(1)2021 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33451088
19.
Protein kinase G phosphorylates the Alzheimer's disease-associated tau protein at distinct Ser/Thr sites.
Biofactors
; 47(1): 126-134, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33469985
20.
Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis.
J Neurochem
; 115(2): 343-52, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20649849